BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 2050688)

  • 21. Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481.
    Iwasaki M; Darden TA; Pedersen LG; Negishi M
    Biochemistry; 1995 Apr; 34(15):5054-9. PubMed ID: 7711025
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
    Halpert JR; He YA
    J Biol Chem; 1993 Feb; 268(6):4453-7. PubMed ID: 8440727
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Primary and secondary structural patterns in eukaryotic cytochrome P-450 families correspond to structures of the helix-rich domain of Pseudomonas putida cytochrome P-450cam. Indications for a similar overall topology.
    Ouzounis CA; Melvin WT
    Eur J Biochem; 1991 Jun; 198(2):307-15. PubMed ID: 2040297
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
    Matsunaga I; Ueda A; Sumimoto T; Ichihara K; Ayata M; Ogura H
    Arch Biochem Biophys; 2001 Oct; 394(1):45-53. PubMed ID: 11566026
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Induction and superinduction of messenger ribonucleic acid specific for aromatase cytochrome P-450 in cultured human skin fibroblasts.
    Berkovitz GD; Chen S; Migeon CJ; Levine MA
    J Clin Endocrinol Metab; 1992 Mar; 74(3):629-34. PubMed ID: 1740498
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450AROM), and their use in its purification.
    Mendelson CR; Wright EE; Evans CT; Porter JC; Simpson ER
    Arch Biochem Biophys; 1985 Dec; 243(2):480-91. PubMed ID: 4083898
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Functional domains of aromatase cytochrome P450 inferred from comparative analyses of amino acid sequences and substantiated by site-directed mutagenesis experiments.
    Chen S; Zhou D
    J Biol Chem; 1992 Nov; 267(31):22587-94. PubMed ID: 1429608
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Structural determinants of aromatase cytochrome p450 inhibition in substrate recognition site-1.
    Conley A; Mapes S; Corbin CJ; Greger D; Graham S
    Mol Endocrinol; 2002 Jul; 16(7):1456-68. PubMed ID: 12089342
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
    Wang Y; Darnay BG; Rodwell VW
    J Biol Chem; 1990 Dec; 265(35):21634-41. PubMed ID: 2123872
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
    He YQ; He YA; Halpert JR
    Chem Res Toxicol; 1995 Jun; 8(4):574-9. PubMed ID: 7548737
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations.
    Auchus RJ; Miller WL
    Mol Endocrinol; 1999 Jul; 13(7):1169-82. PubMed ID: 10406467
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.
    Domanski TL; Schultz KM; Roussel F; Stevens JC; Halpert JR
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1141-7. PubMed ID: 10454488
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Putative functions of phenylalanine-350 of Pseudomonas putida cytochrome P-450cam.
    Yasukochi T; Okada O; Hara T; Sagara Y; Sekimizu K; Horiuchi T
    Biochim Biophys Acta; 1994 Jan; 1204(1):84-90. PubMed ID: 8305479
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Evidence for an elevated aspartate pK(a) in the active site of human aromatase.
    Di Nardo G; Breitner M; Bandino A; Ghosh D; Jennings GK; Hackett JC; Gilardi G
    J Biol Chem; 2015 Jan; 290(2):1186-96. PubMed ID: 25425647
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Regulation of aromatase cytochrome P-450 and 17 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid levels in choriocarcinoma cells.
    Ritvos O; Voutilainen R
    Endocrinology; 1992 Jan; 130(1):61-7. PubMed ID: 1309352
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
    He YA; He YQ; Szklarz GD; Halpert JR
    Biochemistry; 1997 Jul; 36(29):8831-9. PubMed ID: 9220969
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J; He YA; Halpert JR
    Arch Biochem Biophys; 1996 Mar; 327(1):167-73. PubMed ID: 8615687
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Nucleotide sequence of the Pseudomonas putida cytochrome P-450cam gene and its expression in Escherichia coli.
    Unger BP; Gunsalus IC; Sligar SG
    J Biol Chem; 1986 Jan; 261(3):1158-63. PubMed ID: 3003058
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Purification and characterization of equine testicular cytochrome P-450 aromatase: comparison with the human enzyme.
    Moslemi S; Vibet A; Papadopoulos V; Camoin L; Silberzahn P; Gaillard JL
    Comp Biochem Physiol B Biochem Mol Biol; 1997 Sep; 118(1):217-27. PubMed ID: 9418012
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta.
    Mahendroo MS; Means GD; Mendelson CR; Simpson ER
    J Biol Chem; 1991 Jun; 266(17):11276-81. PubMed ID: 2040633
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.