133 related articles for article (PubMed ID: 20530221)
1. Novel metabolic bioactivation mechanism for a series of anti-inflammatory agents (2,5-diaminothiophene derivatives) mediated by cytochrome p450 enzymes.
Hu Y; Yang S; Shilliday FB; Heyde BR; Mandrell KM; Robins RH; Xie J; Reding MT; Lai Y; Thompson DC
Drug Metab Dispos; 2010 Sep; 38(9):1522-31. PubMed ID: 20530221
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
[TBL] [Abstract][Full Text] [Related]
3. Characterization of glutathione conjugates of duloxetine by mass spectrometry and evaluation of in silico approaches to rationalize the site of conjugation for thiophene containing drugs.
Wu G; Vashishtha SC; Erve JC
Chem Res Toxicol; 2010 Aug; 23(8):1393-404. PubMed ID: 20669986
[TBL] [Abstract][Full Text] [Related]
4. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
Kalgutkar AS; Hatch HL; Kosea F; Nguyen HT; Choo EF; McClure KF; Taylor TJ; Henne KR; Kuperman AV; Dombroski MA; Letavic MA
Biopharm Drug Dispos; 2006 Nov; 27(8):371-86. PubMed ID: 16944451
[TBL] [Abstract][Full Text] [Related]
5. Cytochrome P450 oxidation of the thiophene-containing anticancer drug 3-[(quinolin-4-ylmethyl)-amino]-thiophene-2-carboxylic acid (4-trifluoromethoxy-phenyl)-amide to an electrophilic intermediate.
Medower C; Wen L; Johnson WW
Chem Res Toxicol; 2008 Aug; 21(8):1570-7. PubMed ID: 18672911
[TBL] [Abstract][Full Text] [Related]
6. A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
Kalgutkar AS; Driscoll J; Zhao SX; Walker GS; Shepard RM; Soglia JR; Atherton J; Yu L; Mutlib AE; Munchhof MJ; Reiter LA; Jones CS; Doty JL; Trevena KA; Shaffer CL; Ripp SL
Chem Res Toxicol; 2007 Dec; 20(12):1954-65. PubMed ID: 17935300
[TBL] [Abstract][Full Text] [Related]
7. In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
Sahali-Sahly Y; Balani SK; Lin JH; Baillie TA
Chem Res Toxicol; 1996 Sep; 9(6):1007-12. PubMed ID: 8870989
[TBL] [Abstract][Full Text] [Related]
8. Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen.
O'Donnell JP; Dalvie DK; Kalgutkar AS; Obach RS
Drug Metab Dispos; 2003 Nov; 31(11):1369-77. PubMed ID: 14570769
[TBL] [Abstract][Full Text] [Related]
9. Metabolism of the polynuclear sulfur heterocycle benzo[b]phenanthro[2,3-d]thiophene by rodent liver microsomes: evidence for multiple pathways in the bioactivation of benzo[b]phenanthro[2,3-d]thiophene.
Yuan ZX; Sikka HC; Munir S; Kumar A; Muruganandam AV; Kumar S
Chem Res Toxicol; 2003 Dec; 16(12):1581-8. PubMed ID: 14680372
[TBL] [Abstract][Full Text] [Related]
10. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
Wen B; Ma L; Zhu M
Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
[TBL] [Abstract][Full Text] [Related]
11. Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols.
Reddy VB; Karanam BV; Gruber WL; Wallace MA; Vincent SH; Franklin RB; Baillie TA
Chem Res Toxicol; 2005 May; 18(5):880-8. PubMed ID: 15892582
[TBL] [Abstract][Full Text] [Related]
12. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
Alvarez-Diez TM; Zheng J
Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
[TBL] [Abstract][Full Text] [Related]
13. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
Tang W; Stearns RA; Bandiera SM; Zhang Y; Raab C; Braun MP; Dean DC; Pang J; Leung KH; Doss GA; Strauss JR; Kwei GY; Rushmore TH; Chiu SH; Baillie TA
Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
[TBL] [Abstract][Full Text] [Related]
14. Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: role of peroxidases, cytochromes p450, and monoamine oxidases.
Dalvie DK; O'Connell TN
Drug Metab Dispos; 2004 Jan; 32(1):49-57. PubMed ID: 14709620
[TBL] [Abstract][Full Text] [Related]
15. Opposite behaviors of reactive metabolites of tienilic acid and its isomer toward liver proteins: use of specific anti-tienilic acid-protein adduct antibodies and the possible relationship with different hepatotoxic effects of the two compounds.
Bonierbale E; Valadon P; Pons C; Desfosses B; Dansette PM; Mansuy D
Chem Res Toxicol; 1999 Mar; 12(3):286-96. PubMed ID: 10077492
[TBL] [Abstract][Full Text] [Related]
16. Role of human microsomal and human complementary DNA-expressed cytochromes P4501A2 and P4503A4 in the bioactivation of aflatoxin B1.
Gallagher EP; Wienkers LC; Stapleton PL; Kunze KL; Eaton DL
Cancer Res; 1994 Jan; 54(1):101-8. PubMed ID: 8261428
[TBL] [Abstract][Full Text] [Related]
17. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
Shen S; Marchick MR; Davis MR; Doss GA; Pohl LR
Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
[TBL] [Abstract][Full Text] [Related]
18. Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey.
Johnson BM; Kamath AV; Leet JE; Liu X; Bhide RS; Tejwani RW; Zhang Y; Qian L; Wei DD; Lombardo LJ; Shu YZ
Drug Metab Dispos; 2008 Dec; 36(12):2475-83. PubMed ID: 18787055
[TBL] [Abstract][Full Text] [Related]
19. First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives.
Dansette PM; Bertho G; Mansuy D
Biochem Biophys Res Commun; 2005 Dec; 338(1):450-5. PubMed ID: 16137656
[TBL] [Abstract][Full Text] [Related]
20. Bioactivation of 2,3-diaminopyridine-containing bradykinin B1 receptor antagonists: irreversible binding to liver microsomal proteins and formation of glutathione conjugates.
Tang C; Subramanian R; Kuo Y; Krymgold S; Lu P; Kuduk SD; Ng C; Feng DM; Elmore C; Soli E; Ho J; Bock MG; Baillie TA; Prueksaritanont T
Chem Res Toxicol; 2005 Jun; 18(6):934-45. PubMed ID: 15962928
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]