289 related articles for article (PubMed ID: 20537533)
1. Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.
Chonan T; Tanaka H; Yamamoto D; Yashiro M; Oi T; Wakasugi D; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
Bioorg Med Chem Lett; 2010 Jul; 20(13):3965-8. PubMed ID: 20537533
[TBL] [Abstract][Full Text] [Related]
2. (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.
Chonan T; Oi T; Yamamoto D; Yashiro M; Wakasugi D; Tanaka H; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
Bioorg Med Chem Lett; 2009 Dec; 19(23):6645-8. PubMed ID: 19853443
[TBL] [Abstract][Full Text] [Related]
3. Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.
Chonan T; Wakasugi D; Yamamoto D; Yashiro M; Oi T; Tanaka H; Ohoka-Sugita A; Io F; Koretsune H; Hiratate A
Bioorg Med Chem; 2011 Mar; 19(5):1580-93. PubMed ID: 21324704
[TBL] [Abstract][Full Text] [Related]
4. Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.
Kamata M; Yamashita T; Kina A; Funata M; Mizukami A; Sasaki M; Tani A; Funami M; Amano N; Fukatsu K
Bioorg Med Chem Lett; 2012 Jun; 22(11):3643-7. PubMed ID: 22560583
[TBL] [Abstract][Full Text] [Related]
5. Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.
Bourbeau MP; Siegmund A; Allen JG; Shu H; Fotsch C; Bartberger MD; Kim KW; Komorowski R; Graham M; Busby J; Wang M; Meyer J; Xu Y; Salyers K; Fielden M; Véniant MM; Gu W
J Med Chem; 2013 Dec; 56(24):10132-41. PubMed ID: 24294923
[TBL] [Abstract][Full Text] [Related]
6. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.
Bengtsson C; Blaho S; Saitton DB; Brickmann K; Broddefalk J; Davidsson O; Drmota T; Folmer R; Hallberg K; Hallén S; Hovland R; Isin E; Johannesson P; Kull B; Larsson LO; Löfgren L; Nilsson KE; Noeske T; Oakes N; Plowright AT; Schnecke V; Ståhlberg P; Sörme P; Wan H; Wellner E; Oster L
Bioorg Med Chem; 2011 May; 19(10):3039-53. PubMed ID: 21515056
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.
Clark RF; Zhang T; Xin Z; Liu G; Wang Y; Hansen TM; Wang X; Wang R; Zhang X; Frevert EU; Camp HS; Beutel BA; Sham HL; Gu YG
Bioorg Med Chem Lett; 2006 Dec; 16(23):6078-81. PubMed ID: 16973360
[TBL] [Abstract][Full Text] [Related]
8. Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.
Haque TS; Liang N; Golla R; Seethala R; Ma Z; Ewing WR; Cooper CB; Pelleymounter MA; Poss MA; Cheng D
Bioorg Med Chem Lett; 2009 Oct; 19(20):5872-6. PubMed ID: 19740659
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.
Yamashita T; Kamata M; Endo S; Yamamoto M; Kakegawa K; Watanabe H; Miwa K; Yamano T; Funata M; Sakamoto J; Tani A; Mol CD; Zou H; Dougan DR; Sang B; Snell G; Fukatsu K
Bioorg Med Chem Lett; 2011 Nov; 21(21):6314-8. PubMed ID: 21944854
[TBL] [Abstract][Full Text] [Related]
10. Synthesis of spiro[chroman-2,4'-piperidin]-4-one derivatives as acetyl-CoA carboxylase inhibitors.
Shinde P; Srivastava SK; Odedara R; Tuli D; Munshi S; Patel J; Zambad SP; Sonawane R; Gupta RC; Chauthaiwale V; Dutt C
Bioorg Med Chem Lett; 2009 Feb; 19(3):949-53. PubMed ID: 19097787
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of 7-oxo-dihydrospiro[indazole-5,4'-piperidine] acetyl-CoA carboxylase inhibitors.
Bagley SW; Southers JA; Cabral S; Rose CR; Bernhardson DJ; Edmonds DJ; Polivkova J; Yang X; Kung DW; Griffith DA; Bader SJ
J Org Chem; 2012 Feb; 77(3):1497-506. PubMed ID: 22239115
[TBL] [Abstract][Full Text] [Related]
12. Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.
Kamata M; Yamashita T; Kina A; Tawada M; Endo S; Mizukami A; Sasaki M; Tani A; Nakano Y; Watanabe Y; Furuyama N; Funami M; Amano N; Fukatsu K
Bioorg Med Chem Lett; 2012 Jul; 22(14):4769-72. PubMed ID: 22677317
[TBL] [Abstract][Full Text] [Related]
13. Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.
Clark RF; Zhang T; Wang X; Wang R; Zhang X; Camp HS; Beutel BA; Sham HL; Gu YG
Bioorg Med Chem Lett; 2007 Apr; 17(7):1961-5. PubMed ID: 17267221
[TBL] [Abstract][Full Text] [Related]
14. Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Sun D; Wang Z; Di Y; Jaen JC; Labelle M; Ma J; Miao S; Sudom A; Tang L; Tomooka CS; Tu H; Ursu S; Walker N; Yan X; Ye Q; Powers JP
Bioorg Med Chem Lett; 2008 Jun; 18(12):3513-6. PubMed ID: 18511278
[TBL] [Abstract][Full Text] [Related]
15. Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors.
Huang T; Sun J; Wang Q; Gao J; Liu Y
Molecules; 2015 Sep; 20(9):16221-34. PubMed ID: 26370948
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of piperidine farnesyltransferase inhibitors with reduced glucuronidation potential.
Tanaka R; Rubio A; Harn NK; Gernert D; Grese TA; Eishima J; Hara M; Yoda N; Ohashi R; Kuwabara T; Soga S; Akinaga S; Nara S; Kanda Y
Bioorg Med Chem; 2007 Feb; 15(3):1363-82. PubMed ID: 17127066
[TBL] [Abstract][Full Text] [Related]
17. Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.
Corbett JW
Expert Opin Ther Pat; 2009 Jul; 19(7):943-56. PubMed ID: 19552511
[TBL] [Abstract][Full Text] [Related]
18. Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.
Andrews DM; Stokes ES; Carr GR; Matusiak ZS; Roberts CA; Waring MJ; Brady MC; Chresta CM; East SJ
Bioorg Med Chem Lett; 2008 Apr; 18(8):2580-4. PubMed ID: 18378449
[TBL] [Abstract][Full Text] [Related]
19. Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors.
Xin Z; Zhao H; Serby MD; Liu B; Liu M; Szczepankiewicz BG; Nelson LT; Smith HT; Suhar TS; Janis RS; Cao N; Camp HS; Collins CA; Sham HL; Surowy TK; Liu G
Bioorg Med Chem Lett; 2008 Aug; 18(15):4298-302. PubMed ID: 18632269
[TBL] [Abstract][Full Text] [Related]
20. Stereoselective synthesis and glycosidase inhibitory activity of 3,4-dihydroxy-pyrrolidin-2-one, 3,4-dihydroxy-piperidin-2-one and 1,2-dihydroxy-pyrrolizidin-3-one.
Coutrot P; Claudel S; Didierjean C; Grison C
Bioorg Med Chem Lett; 2006 Jan; 16(2):417-20. PubMed ID: 16271473
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
