BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

102 related articles for article (PubMed ID: 20545486)

  • 21. Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leucocyte elastase.
    Knight WB; Green BG; Chabin RM; Gale P; Maycock AL; Weston H; Kuo DW; Westler WM; Dorn CP; Finke PE
    Biochemistry; 1992 Sep; 31(35):8160-70. PubMed ID: 1525156
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
    Devadas B; Freeman SK; Zupec ME; Lu HF; Nagarajan SR; Kishore NS; Lodge JK; Kuneman DW; McWherter CA; Vinjamoori DV; Getman DP; Gordon JI; Sikorski JA
    J Med Chem; 1997 Aug; 40(16):2609-25. PubMed ID: 9258368
    [TBL] [Abstract][Full Text] [Related]  

  • 23. [Reactions of derivatives of beta-lactam antibiotics with non-antibacterial biological activity].
    Gunda T
    Acta Pharm Hung; 2002; 72(4):223-30. PubMed ID: 12812042
    [TBL] [Abstract][Full Text] [Related]  

  • 24. 6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity.
    Vagnoni LM; Gronostaj M; Kerrigan JE
    Bioorg Med Chem; 2001 Mar; 9(3):637-45. PubMed ID: 11310598
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations.
    Estácio SG; Moreira R; Guedes RC
    J Chem Inf Model; 2011 Jul; 51(7):1690-702. PubMed ID: 21639142
    [TBL] [Abstract][Full Text] [Related]  

  • 26. 1H-pyrazolo[2,3-d][1,2,4]triazine-3,7-diones as a new class of human leukocyte elastase inhibitors.
    Baraldi PG; Cacciari B; Romagnoli R; Spalluto G
    Arzneimittelforschung; 1999 Dec; 49(12):997-1000. PubMed ID: 10635444
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives.
    Lai Z; Gan X; Wei L; Alliston KR; Yu H; Li YH; Groutas WC
    Arch Biochem Biophys; 2004 Sep; 429(2):191-7. PubMed ID: 15313222
    [TBL] [Abstract][Full Text] [Related]  

  • 28. N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.
    Iijima K; Katada J; Yasuda E; Uno I; Hayashi Y
    J Med Chem; 1999 Jan; 42(2):312-23. PubMed ID: 9925737
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Inhibitors of metallo-beta-lactamase generated from beta-lactam antibiotics.
    Badarau A; Llinás A; Laws AP; Damblon C; Page MI
    Biochemistry; 2005 Jun; 44(24):8578-89. PubMed ID: 15952764
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors.
    Gérard S; Galleni M; Dive G; Marchand-Brynaert J
    Bioorg Med Chem; 2004 Jan; 12(1):129-38. PubMed ID: 14697778
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Mechanism of inhibition of human leucocyte elastase by beta-lactams. 3. Use of electrospray ionization mass spectrometry and two-dimensional NMR techniques to identify beta-lactam-derived E-I complexes.
    Underwood DJ; Green BG; Chabin R; Mills S; Doherty JB; Finke PE; MacCoss M; Shah SK; Burgey CS; Dickinson TA
    Biochemistry; 1995 Nov; 34(44):14344-55. PubMed ID: 7578038
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Different transition-state structures for the reactions of beta-lactams and analogous beta-sultams with serine beta-lactamases.
    Tsang WY; Ahmed N; Hinchliffe PS; Wood JM; Harding LP; Laws AP; Page MI
    J Am Chem Soc; 2005 Dec; 127(49):17556-64. PubMed ID: 16332108
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolution.
    Nakanishi I; Kinoshita T; Sato A; Tada T
    Biopolymers; 2000 Apr; 53(5):434-45. PubMed ID: 10738204
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Novel thieno[2,3-d][1,3]oxazin-4-ones as inhibitors of human leukocyte elastase.
    Gütschow M; Neumann U
    J Med Chem; 1998 May; 41(10):1729-40. PubMed ID: 9572899
    [TBL] [Abstract][Full Text] [Related]  

  • 35. New peptolides from the cyanobacterium Nostoc insulare as selective and potent inhibitors of human leukocyte elastase.
    Mehner C; Müller D; Kehraus S; Hautmann S; Gütschow M; König GM
    Chembiochem; 2008 Nov; 9(16):2692-703. PubMed ID: 18924217
    [TBL] [Abstract][Full Text] [Related]  

  • 36. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH): evidence of a nonhydrolytic process.
    Feledziak M; Muccioli GG; Lambert DM; Marchand-Brynaert J
    J Med Chem; 2011 Oct; 54(19):6812-23. PubMed ID: 21899370
    [TBL] [Abstract][Full Text] [Related]  

  • 37. beta-Lactam derivatives as enzyme inhibitors: derivatives of (E)-2-[(RS)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-ylidene]propionic acid.
    Venz C; Otto HH
    Pharmazie; 2001 Sep; 56(9):686-90. PubMed ID: 11593986
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process.
    Wei L; Lai Z; Gan X; Alliston KR; Zhong J; Epp JB; Tu J; Perera AB; Van Stipdonk M; Groutas WC
    Arch Biochem Biophys; 2004 Sep; 429(1):60-70. PubMed ID: 15288810
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Mechanism of inhibition of human leucocyte elastase by beta-lactams. 2. Stability, reactivation kinetics, and products of beta-lactam-derived E-I complexes.
    Green BG; Chabin R; Mills S; Underwood DJ; Shah SK; Kuo D; Gale P; Maycock AL; Liesch J; Burgey CS
    Biochemistry; 1995 Nov; 34(44):14331-43. PubMed ID: 7578037
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Orally active inhibitors of human leukocyte elastase. I. Disposition of L-683,845 in rats and rhesus monkeys.
    Vincent SH; Painter SK; Krieter PA; Colletti AE; Lyszack E; Rosegay A; Dean D; Luffer-Atlas D; Miller RR; Cioffe C; Chiu SH
    Drug Metab Dispos; 1996 Dec; 24(12):1369-77. PubMed ID: 8971144
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 6.