BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 20546605)

  • 1. Characterization of AKT independent effects of the synthetic AKT inhibitors SH-5 and SH-6 using an integrated approach combining transcriptomic profiling and signaling pathway perturbations.
    Krech T; Thiede M; Hilgenberg E; Schäfer R; Jürchott K
    BMC Cancer; 2010 Jun; 10():287. PubMed ID: 20546605
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
    Sethi G; Ahn KS; Sung B; Kunnumakkara AB; Chaturvedi MM; Aggarwal BB
    Biochem Pharmacol; 2008 Dec; 76(11):1404-16. PubMed ID: 18606397
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.
    Falasca M; Chiozzotto D; Godage HY; Mazzoletti M; Riley AM; Previdi S; Potter BV; Broggini M; Maffucci T
    Br J Cancer; 2010 Jan; 102(1):104-14. PubMed ID: 20051961
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Calycosin induces apoptosis in colorectal cancer cells, through modulating the ERβ/MiR-95 and IGF-1R, PI3K/Akt signaling pathways.
    Zhao X; Li X; Ren Q; Tian J; Chen J
    Gene; 2016 Oct; 591(1):123-128. PubMed ID: 27393650
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.
    Zhang C; Elkahloun AG; Liao H; Delaney S; Saber B; Morrow B; Prendergast GC; Hollander MC; Gills JJ; Dennis PA
    Mol Cancer Ther; 2011 Jul; 10(7):1137-48. PubMed ID: 21551261
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.
    Chang L; Wu P; Senthilkumar R; Tian X; Liu H; Shen X; Tao Z; Huang P
    J Cancer Res Clin Oncol; 2016 Jan; 142(1):59-72. PubMed ID: 26109148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors.
    Smit DJ; Cayrefourcq L; Haider MT; Hinz N; Pantel K; Alix-Panabières C; Jücker M
    Cells; 2020 Sep; 9(9):. PubMed ID: 32962206
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cotreatment with a novel phosphoinositide analogue inhibitor and carmustine enhances chemotherapeutic efficacy by attenuating AKT activity in gliomas.
    Van Meter TE; Broaddus WC; Cash D; Fillmore H
    Cancer; 2006 Nov; 107(10):2446-54. PubMed ID: 17041888
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.
    Wang BD; Kline CL; Pastor DM; Olson TL; Frank B; Luu T; Sharma AK; Robertson G; Weirauch MT; Patierno SR; Stuart JM; Irby RB; Lee NH
    Mol Cancer; 2010 Apr; 9():98. PubMed ID: 20433755
    [TBL] [Abstract][Full Text] [Related]  

  • 10. LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.
    Vakana E; Pratt S; Blosser W; Dowless M; Simpson N; Yuan XJ; Jaken S; Manro J; Stephens J; Zhang Y; Huber L; Peng SB; Stancato LF
    Oncotarget; 2017 Feb; 8(6):9251-9266. PubMed ID: 27999210
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway.
    Tabellini G; Tazzari PL; Bortul R; Billi AM; Conte R; Manzoli L; Cocco L; Martelli AM
    Br J Haematol; 2004 Aug; 126(4):574-82. PubMed ID: 15287952
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.
    Yang XM; Cao XY; He P; Li J; Feng MX; Zhang YL; Zhang XL; Wang YH; Yang Q; Zhu L; Nie HZ; Jiang SH; Tian GA; Zhang XX; Liu Q; Ji J; Zhu X; Xia Q; Zhang ZG
    Gastroenterology; 2018 Oct; 155(4):1233-1249.e22. PubMed ID: 30009820
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target.
    Liu G; Song Y; Cui L; Wen Z; Lu X
    Int J Clin Exp Pathol; 2015; 8(2):1402-10. PubMed ID: 25973024
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells.
    Martinelli E; Troiani T; D'Aiuto E; Morgillo F; Vitagliano D; Capasso A; Costantino S; Ciuffreda LP; Merolla F; Vecchione L; De Vriendt V; Tejpar S; Nappi A; Sforza V; Martini G; Berrino L; De Palma R; Ciardiello F
    Int J Cancer; 2013 Nov; 133(9):2089-101. PubMed ID: 23629727
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells.
    de Araujo WM; Robbs BK; Bastos LG; de Souza WF; Vidal FC; Viola JP; Morgado-Diaz JA
    J Cell Biochem; 2016 Feb; 117(2):458-69. PubMed ID: 26224641
    [TBL] [Abstract][Full Text] [Related]  

  • 16. In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316.
    Meuillet EJ; Ihle N; Baker AF; Gard JM; Stamper C; Williams R; Coon A; Mahadevan D; George BL; Kirkpatrick L; Powis G
    Oncol Res; 2004; 14(10):513-27. PubMed ID: 15559765
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Isofraxidin inhibited proliferation and induced apoptosis via blockage of Akt pathway in human colorectal cancer cells.
    Shen P; Wang HG; Li MM; Ma QY; Zhou CW; Pan F; Xie R
    Biomed Pharmacother; 2017 Aug; 92():78-85. PubMed ID: 28531803
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway.
    Soo HC; Chung FF; Lim KH; Yap VA; Bradshaw TD; Hii LW; Tan SH; See SJ; Tan YF; Leong CO; Mai CW
    PLoS One; 2017; 12(1):e0170551. PubMed ID: 28107519
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway.
    Yang ZP; Zhao Y; Huang F; Chen J; Yao YH; Li J; Wu XN
    World J Gastroenterol; 2015 Sep; 21(36):10385-99. PubMed ID: 26420965
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of miR-19a partially reversed the resistance of colorectal cancer to oxaliplatin via PTEN/PI3K/AKT pathway.
    Zhang Y; Liu X; Zhang J; Xu Y; Shao J; Hu Y; Shu P; Cheng H
    Aging (Albany NY); 2020 Mar; 12(7):5640-5650. PubMed ID: 32209726
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.