BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

282 related articles for article (PubMed ID: 20570726)

  • 1. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
    Tonelli F; Lim KG; Loveridge C; Long J; Pitson SM; Tigyi G; Bittman R; Pyne S; Pyne NJ
    Cell Signal; 2010 Oct; 22(10):1536-42. PubMed ID: 20570726
    [TBL] [Abstract][Full Text] [Related]  

  • 2. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells.
    Lim KG; Tonelli F; Li Z; Lu X; Bittman R; Pyne S; Pyne NJ
    J Biol Chem; 2011 May; 286(21):18633-40. PubMed ID: 21464128
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.
    Tonelli F; Alossaimi M; Williamson L; Tate RJ; Watson DG; Chan E; Bittman R; Pyne NJ; Pyne S
    Br J Pharmacol; 2013 Mar; 168(6):1497-505. PubMed ID: 23113536
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.
    Lim KG; Tonelli F; Berdyshev E; Gorshkova I; Leclercq T; Pitson SM; Bittman R; Pyne S; Pyne NJ
    Int J Biochem Cell Biol; 2012 Sep; 44(9):1457-64. PubMed ID: 22634604
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
    Lu X; Sun C; Valentine WJ; Shuyu E; Liu J; Tigyi G; Bittman R
    J Org Chem; 2009 Apr; 74(8):3192-5. PubMed ID: 19296586
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
    Loveridge C; Tonelli F; Leclercq T; Lim KG; Long JS; Berdyshev E; Tate RJ; Natarajan V; Pitson SM; Pyne NJ; Pyne S
    J Biol Chem; 2010 Dec; 285(50):38841-52. PubMed ID: 20926375
    [TBL] [Abstract][Full Text] [Related]  

  • 7. (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
    Valentine WJ; Kiss GN; Liu J; E S; Gotoh M; Murakami-Murofushi K; Pham TC; Baker DL; Parrill AL; Lu X; Sun C; Bittman R; Pyne NJ; Tigyi G
    Cell Signal; 2010 Oct; 22(10):1543-53. PubMed ID: 20566326
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis of selective inhibitors of sphingosine kinase 1.
    Baek DJ; MacRitchie N; Pyne NJ; Pyne S; Bittman R
    Chem Commun (Camb); 2013 Mar; 49(21):2136-8. PubMed ID: 23388656
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
    McNaughton M; Pitman M; Pitson SM; Pyne NJ; Pyne S
    Oncotarget; 2016 Mar; 7(13):16663-75. PubMed ID: 26934645
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
    Nagaoka Y; Otsuki K; Fujita T; Uesato S
    Biol Pharm Bull; 2008 Jun; 31(6):1177-81. PubMed ID: 18520051
    [TBL] [Abstract][Full Text] [Related]  

  • 11. (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells.
    Lim KG; Sun C; Bittman R; Pyne NJ; Pyne S
    Cell Signal; 2011 Oct; 23(10):1590-5. PubMed ID: 21620961
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor.
    Oo ML; Thangada S; Wu MT; Liu CH; Macdonald TL; Lynch KR; Lin CY; Hla T
    J Biol Chem; 2007 Mar; 282(12):9082-9. PubMed ID: 17237497
    [TBL] [Abstract][Full Text] [Related]  

  • 13. FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.
    Spijkers LJ; Alewijnse AE; Peters SL
    Br J Pharmacol; 2012 Jun; 166(4):1411-8. PubMed ID: 22251137
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.
    Watson DG; Tonelli F; Alossaimi M; Williamson L; Chan E; Gorshkova I; Berdyshev E; Bittman R; Pyne NJ; Pyne S
    Cell Signal; 2013 Apr; 25(4):1011-7. PubMed ID: 23314175
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.
    Tonelli F; Alossaimi M; Natarajan V; Gorshkova I; Berdyshev E; Bittman R; Watson DG; Pyne S; Pyne NJ
    Biomolecules; 2013 Jun; 3(2):316-33. PubMed ID: 24970170
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.
    Raje MR; Knott K; Kharel Y; Bissel P; Lynch KR; Santos WL
    Bioorg Med Chem; 2012 Jan; 20(1):183-94. PubMed ID: 22137932
    [TBL] [Abstract][Full Text] [Related]  

  • 17. FTY720 and cisplatin synergistically induce the death of cisplatin-resistant melanoma cells through the downregulation of the PI3K pathway and the decrease in epidermal growth factor receptor expression.
    Ishitsuka A; Fujine E; Mizutani Y; Tawada C; Kanoh H; Banno Y; Seishima M
    Int J Mol Med; 2014 Oct; 34(4):1169-74. PubMed ID: 25109763
    [TBL] [Abstract][Full Text] [Related]  

  • 18. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
    Berdyshev EV; Gorshkova I; Skobeleva A; Bittman R; Lu X; Dudek SM; Mirzapoiazova T; Garcia JG; Natarajan V
    J Biol Chem; 2009 Feb; 284(9):5467-77. PubMed ID: 19119142
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular targets of FTY720 (fingolimod).
    Pitman MR; Woodcock JM; Lopez AF; Pitson SM
    Curr Mol Med; 2012 Dec; 12(10):1207-19. PubMed ID: 22834825
    [TBL] [Abstract][Full Text] [Related]  

  • 20. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
    Pchejetski D; Bohler T; Brizuela L; Sauer L; Doumerc N; Golzio M; Salunkhe V; Teissié J; Malavaud B; Waxman J; Cuvillier O
    Cancer Res; 2010 Nov; 70(21):8651-61. PubMed ID: 20959468
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.