BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

206 related articles for article (PubMed ID: 20570743)

  • 1. Cardiovascular safety assessments in the conscious telemetered dog: utilisation of super-intervals to enhance statistical power.
    Sivarajah A; Collins S; Sutton MR; Regan N; West H; Holbrook M; Edmunds N
    J Pharmacol Toxicol Methods; 2010; 62(1):12-9. PubMed ID: 20570743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Application of a probabilistic method for the determination of drug-induced QT prolongation in telemetered cynomolgus monkeys: effects of moxifloxacin.
    Holzgrefe HH; Cavero I; Buchanan LV; Gill MW; Durham SK
    J Pharmacol Toxicol Methods; 2007; 55(3):227-37. PubMed ID: 17097307
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.
    Chaves AA; Zingaro GJ; Yordy MA; Bustard KA; O'Sullivan S; Galijatovic-Idrizbegovic A; Schuck H; Christian DB; Hoe CM; Briscoe RJ
    J Pharmacol Toxicol Methods; 2007; 56(2):103-14. PubMed ID: 17643323
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Validation of the normal, freely moving Göttingen minipig for pharmacological safety testing.
    Markert M; Stubhan M; Mayer K; Trautmann T; Klumpp A; Schuler-Metz A; Schumacher K; Guth B
    J Pharmacol Toxicol Methods; 2009; 60(1):79-87. PubMed ID: 19427912
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.
    Chaves AA; Keller WJ; O'Sullivan S; Williams MA; Fitzgerald LE; McPherson HE; Goykhman D; Ward PD; Hoe CM; Mixson L; Briscoe RJ
    J Pharmacol Toxicol Methods; 2006; 54(2):150-8. PubMed ID: 16679034
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Comparison of the QT interval response during sinus and paced rhythm in conscious and anesthetized beagle dogs.
    Ollerstam A; Visser SA; Duker G; Forsberg T; Persson AH; Nilsson LB; Björkman JA; Gabrielsson J; Al-Saffar A
    J Pharmacol Toxicol Methods; 2007; 56(2):131-44. PubMed ID: 17689270
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Long-term stability, reproducibility, and statistical sensitivity of a telemetry-instrumented dog model: A 27-month longitudinal assessment.
    Fryer RM; Ng KJ; Chi L; Jin X; Reinhart GA
    J Pharmacol Toxicol Methods; 2015; 74():26-32. PubMed ID: 25946685
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Left thoracotomy surgical approach for chronic instrumentation in dogs and monkeys providing high-quality electrocardiogram signals.
    Henriques TA; Beck TW; Douglas CL; Jones HM; Kremer JJ; Kruzich PJ; Sarazan RD
    J Pharmacol Toxicol Methods; 2010; 62(2):136-42. PubMed ID: 20550968
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The effects of housing conditions on baseline cardiovascular parameters and the sensitivity to detect changes in contractility in telemetry-implanted dogs.
    Sadekova N; Boudreau G; Jalbert B; Norton K
    J Pharmacol Toxicol Methods; 2016; 81():60-74. PubMed ID: 27163176
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Cardiovascular parameters in anaesthetized guinea pigs: a safety pharmacology screening model.
    Hauser DS; Stade M; Schmidt A; Hanauer G
    J Pharmacol Toxicol Methods; 2005; 52(1):106-14. PubMed ID: 15961325
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effects of group housing on ECG assessment in conscious cynomolgus monkeys.
    Xing G; Lu J; Hu M; Wang S; Zhao L; Zheng W; Schofield J; Oldman K; Adkins D; Yu H; Platz S; Ren J; Skinner M
    J Pharmacol Toxicol Methods; 2015; 75():44-51. PubMed ID: 25979821
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Statistical power analysis of cardiovascular safety pharmacology studies in conscious rats.
    Bhatt S; Li D; Flynn D; Wisialowski T; Hemkens M; Steidl-Nichols J
    J Pharmacol Toxicol Methods; 2016; 81():128-35. PubMed ID: 27071954
    [TBL] [Abstract][Full Text] [Related]  

  • 13. QT prolongation and proarrhythmia by moxifloxacin: concordance of preclinical models in relation to clinical outcome.
    Chen X; Cass JD; Bradley JA; Dahm CM; Sun Z; Kadyszewski E; Engwall MJ; Zhou J
    Br J Pharmacol; 2005 Nov; 146(6):792-9. PubMed ID: 16158069
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Translational pharmacokinetic-pharmacodynamic modeling of QTc effects in dog and human.
    Parkinson J; Visser SA; Jarvis P; Pollard C; Valentin JP; Yates JW; Ewart L
    J Pharmacol Toxicol Methods; 2013; 68(3):357-66. PubMed ID: 23567074
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ILSI-HESI cardiovascular safety subcommittee dataset: an analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc).
    Chiang AY; Bass AS; Cooper MM; Engwall MJ; Menton RG; Thomas K
    J Pharmacol Toxicol Methods; 2007; 56(2):95-102. PubMed ID: 17588780
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Intravenous solid tip ECG lead placement in telemetry implanted dogs: Part 2: High quality telemetry signals yield high sensitivity to drug-induced changes.
    Mitchell AZ; Bills AJ; Wittwer GT; Foley CM; Kremer JJ; Chen H; Osinski MA
    J Pharmacol Toxicol Methods; 2013; 68(1):62-73. PubMed ID: 23639348
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Correction of QT values to allow for increases in heart rate in conscious Beagle dogs in toxicology assessment.
    Tattersall ML; Dymond M; Hammond T; Valentin JP
    J Pharmacol Toxicol Methods; 2006; 53(1):11-9. PubMed ID: 15886026
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Validation and utility of the PhysioTel™ Digital M11 telemetry implant for cardiovascular data evaluation in cynomolgus monkeys and Beagle dogs.
    Cordes JS; Heyen JR; Volberg ML; Poy N; Kreuser S; Shoieb AM; Steidl-Nichols J
    J Pharmacol Toxicol Methods; 2016; 79():72-9. PubMed ID: 26844408
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys.
    Watson KJ; Gorczyca WP; Umland J; Zhang Y; Chen X; Sun SZ; Fermini B; Holbrook M; Van Der Graaf PH
    J Pharmacol Toxicol Methods; 2011; 63(3):304-13. PubMed ID: 21419854
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.
    Caruso A; Frances N; Meille C; Greiter-Wilke A; Hillebrecht A; Lavé T
    J Pharmacol Toxicol Methods; 2014; 70(1):73-85. PubMed ID: 24879942
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.