BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

271 related articles for article (PubMed ID: 20583325)

  • 1. Use of stable isotope labeled probes to facilitate liquid chromatography/mass spectrometry based high-throughput screening of time-dependent CYP inhibitors.
    Dasgupta M; Tang W; Caldwell GW; Yan Z
    Rapid Commun Mass Spectrom; 2010 Aug; 24(15):2177-85. PubMed ID: 20583325
    [TBL] [Abstract][Full Text] [Related]  

  • 2. High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis.
    Halladay JS; Delarosa EM; Tran D; Wang L; Wong S; Khojasteh SC
    Drug Metab Lett; 2011 Aug; 5(3):220-30. PubMed ID: 21867481
    [TBL] [Abstract][Full Text] [Related]  

  • 3. High-throughput cytochrome p450 inhibition assays by ultrafast gradient liquid chromatography with tandem mass spectrometry using monolithic columns.
    Peng SX; Barbone AG; Ritchie DM
    Rapid Commun Mass Spectrom; 2003; 17(6):509-18. PubMed ID: 12621611
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.
    Bhoopathy S; Xin B; Unger SE; Karnes HT
    J Pharm Biomed Anal; 2005 Apr; 37(4):739-49. PubMed ID: 15797796
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Development of a high-throughput online solid-phase extraction/tandem mass spectrometry method for cytochrome P450 inhibition screening.
    Lim KB; Ozbal CC; Kassel DB
    J Biomol Screen; 2010 Apr; 15(4):447-52. PubMed ID: 20208033
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery.
    Bell L; Bickford S; Nguyen PH; Wang J; He T; Zhang B; Friche Y; Zimmerlin A; Urban L; Bojanic D
    J Biomol Screen; 2008 Jun; 13(5):343-53. PubMed ID: 18474896
    [TBL] [Abstract][Full Text] [Related]  

  • 7. High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry.
    Wu J; Hughes CS; Picard P; Letarte S; Gaudreault M; Lévesque JF; Nicoll-Griffith DA; Bateman KP
    Anal Chem; 2007 Jun; 79(12):4657-65. PubMed ID: 17497828
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A high-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
    Qin CZ; Ren X; Tan ZR; Chen Y; Yin JY; Yu J; Qu J; Zhou HH; Liu ZQ
    Biomed Chromatogr; 2014 Feb; 28(2):197-203. PubMed ID: 23946123
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quantitative protein determination for CYP induction via LC-MS/MS.
    Williamson BL; Purkayastha S; Hunter CL; Nuwaysir L; Hill J; Easterwood L; Hill J
    Proteomics; 2011 Jan; 11(1):33-41. PubMed ID: 21182192
    [TBL] [Abstract][Full Text] [Related]  

  • 10. High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites.
    Bu HZ; Magis L; Knuth K; Teitelbaum P
    Rapid Commun Mass Spectrom; 2000; 14(17):1619-24. PubMed ID: 10960916
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe.
    Chauret N; Tremblay N; Lackman RL; Gauthier JY; Silva JM; Marois J; Yergey JA; Nicoll-Griffith DA
    Anal Biochem; 1999 Dec; 276(2):215-26. PubMed ID: 10603245
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
    Zhang W; Han F; Guo P; Zhao H; Lin ZJ; Huang MQ; Bertelsen K; Weng N
    J Chromatogr B Analyt Technol Biomed Life Sci; 2010 May; 878(15-16):1169-77. PubMed ID: 20378422
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry.
    Xu R; Manuel M; Cramlett J; Kassel DB
    J Chromatogr A; 2010 Mar; 1217(10):1616-25. PubMed ID: 20132940
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Validated method for rapid inhibition screening of six cytochrome P450 enzymes by liquid chromatography-tandem mass spectrometry.
    Li X; Chen X; Li Q; Wang L; Zhong D
    J Chromatogr B Analyt Technol Biomed Life Sci; 2007 Jun; 852(1-2):128-37. PubMed ID: 17267297
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rapid determination of six metabolites from multiple cytochrome P450 probe substrates in human liver microsome by liquid chromatography/mass spectrometry: application to high-throughput inhibition screening of terpenoids.
    He F; Bi HC; Xie ZY; Zuo Z; Li JK; Li X; Zhao LZ; Chen X; Huang M
    Rapid Commun Mass Spectrom; 2007; 21(5):635-43. PubMed ID: 17279482
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS.
    Zambon S; Fontana S; Kajbaf M
    Drug Metab Lett; 2010 Aug; 4(3):120-8. PubMed ID: 20642444
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Evaluation of time-dependent cytochrome p450 inhibition in a high-throughput, automated assay: introducing a novel area under the curve shift approach.
    Mukadam S; Tay S; Tran D; Wang L; Delarosa EM; Khojasteh SC; Halladay JS; Kenny JR
    Drug Metab Lett; 2012 Mar; 6(1):43-53. PubMed ID: 22372554
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Reliable high-throughput method for inhibition assay of 8 cytochrome P450 isoforms using cocktail of probe substrates and stable isotope-labeled internal standards.
    Kozakai K; Yamada Y; Oshikata M; Kawase T; Suzuki E; Haramaki Y; Taniguchi H
    Drug Metab Pharmacokinet; 2012; 27(5):520-9. PubMed ID: 22498647
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery.
    Smith D; Sadagopan N; Zientek M; Reddy A; Cohen L
    J Chromatogr B Analyt Technol Biomed Life Sci; 2007 May; 850(1-2):455-63. PubMed ID: 17270503
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A sensitive and high-throughput LC-MS/MS method for inhibition assay of seven major cytochrome P450s in human liver microsomes using an in vitro cocktail of probe substrates.
    Liu LY; Han YL; Zhu JH; Yu Q; Yang QJ; Lu J; Guo C
    Biomed Chromatogr; 2015 Mar; 29(3):437-44. PubMed ID: 25098274
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.