These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

79 related articles for article (PubMed ID: 20594845)

  • 1. Addressing PXR liabilities of phthalazine-based hedgehog/smoothened antagonists using novel pyridopyridazines.
    Kaizerman JA; Aaron W; An S; Austin R; Brown M; Chong A; Huang T; Hungate R; Jiang B; Johnson MG; Lee G; Lucas BS; Orf J; Rong M; Toteva MM; Wickramasinghe D; Xu G; Ye Q; Zhong W; McMinn DL
    Bioorg Med Chem Lett; 2010 Aug; 20(15):4607-10. PubMed ID: 20594845
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.
    Miller-Moslin K; Peukert S; Jain RK; McEwan MA; Karki R; Llamas L; Yusuff N; He F; Li Y; Sun Y; Dai M; Perez L; Michael W; Sheng T; Lei H; Zhang R; Williams J; Bourret A; Ramamurthy A; Yuan J; Guo R; Matsumoto M; Vattay A; Maniara W; Amaral A; Dorsch M; Kelleher JF
    J Med Chem; 2009 Jul; 52(13):3954-68. PubMed ID: 19469545
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists.
    Lucas BS; Aaron W; An S; Austin RJ; Brown M; Chan H; Chong A; Hungate R; Huang T; Jiang B; Johnson MG; Kaizerman JA; Lee G; McMinn DL; Orf J; Powers JP; Rong M; Toteva MM; Uyeda C; Wickramasinghe D; Xu G; Ye Q; Zhong W
    Bioorg Med Chem Lett; 2010 Jun; 20(12):3618-22. PubMed ID: 20493695
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.
    Peukert S; Jain RK; Geisser A; Sun Y; Zhang R; Bourret A; Carlson A; Dasilva J; Ramamurthy A; Kelleher JF
    Bioorg Med Chem Lett; 2009 Jan; 19(2):328-31. PubMed ID: 19091559
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of NVP-LEQ506, a second-generation inhibitor of smoothened.
    Peukert S; He F; Dai M; Zhang R; Sun Y; Miller-Moslin K; McEwan M; Lagu B; Wang K; Yusuff N; Bourret A; Ramamurthy A; Maniara W; Amaral A; Vattay A; Wang A; Guo R; Yuan J; Green J; Williams J; Buonamici S; Kelleher JF; Dorsch M
    ChemMedChem; 2013 Aug; 8(8):1261-5. PubMed ID: 23821351
    [No Abstract]   [Full Text] [Related]  

  • 6. Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.
    Lu X; Peng Y; Wang C; Yang J; Bao X; Dong Q; Zhao W; Tan W; Dong X
    Eur J Med Chem; 2017 Sep; 138():384-395. PubMed ID: 28688278
    [TBL] [Abstract][Full Text] [Related]  

  • 7. N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.
    Muraglia E; Ontoria JM; Branca D; Dessole G; Bresciani A; Fonsi M; Giuliano C; Llauger Bufi L; Monteagudo E; Palumbi MC; Torrisi C; Rowley M; Steinkühler C; Jones P
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5283-8. PubMed ID: 21802943
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and biological evaluation of novel benzamide derivatives as potent smoothened antagonists.
    Wu TM; Wang DC; Xiang P; Zhang JN; Sang YX; Lin HJ; Chen J; Xie G; Song H; Zhao YL; Xie YM
    Bioorg Med Chem Lett; 2014 Mar; 24(5):1426-31. PubMed ID: 24491459
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of novel dimethylpyridazine derivatives as hedgehog signaling pathway inhibitors.
    Wang C; Zhu M; Lu X; Wang H; Zhao W; Zhang X; Dong X
    Bioorg Med Chem; 2018 Jul; 26(12):3308-3320. PubMed ID: 29739714
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The hedgehog pathway and pancreatic cancer.
    Hidalgo M; Maitra A
    N Engl J Med; 2009 Nov; 361(21):2094-6. PubMed ID: 19923581
    [No Abstract]   [Full Text] [Related]  

  • 11. Synthesis and evaluation of novel benzylphthalazine derivatives as hedgehog signaling pathway inhibitors.
    Bao X; Peng Y; Lu X; Yang J; Zhao W; Tan W; Dong X
    Bioorg Med Chem Lett; 2016 Jul; 26(13):3048-3051. PubMed ID: 27180012
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
    Wang J; Mook RA; Lu J; Gooden DM; Ribeiro A; Guo A; Barak LS; Lyerly HK; Chen W
    Bioorg Med Chem; 2012 Nov; 20(22):6751-7. PubMed ID: 23063522
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Small-molecule inhibitors of the hedgehog signaling pathway as cancer therapeutics.
    Peukert S; Miller-Moslin K
    ChemMedChem; 2010 Apr; 5(4):500-12. PubMed ID: 20229564
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Small-molecule modulators of the Sonic Hedgehog signaling pathway.
    Stanton BZ; Peng LF
    Mol Biosyst; 2010 Jan; 6(1):44-54. PubMed ID: 20024066
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hedgehog signaling pathway: development of antagonists for cancer therapy.
    Xie J
    Curr Oncol Rep; 2008 Mar; 10(2):107-13. PubMed ID: 18377823
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Different effects of anti-sonic hedgehog antibodies and the hedgehog pathway inhibitor cyclopamine on generation of dopaminergic neurons from neurospheres of mesencephalic precursors.
    Parga JA; Rodriguez-Pallares J; Blanco V; Guerra MJ; Labandeira-Garcia JL
    Dev Dyn; 2008 Apr; 237(4):909-17. PubMed ID: 18330924
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of a series of 4-[3-(quinolin-2-yl)-1,2,4-oxadiazol-5-yl]piperazinyl ureas as potent smoothened antagonist hedgehog pathway inhibitors.
    Ontoria JM; Bufi LL; Torrisi C; Bresciani A; Giomini C; Rowley M; Serafini S; Bin H; Hao W; Steinkühler C; Jones P
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5274-82. PubMed ID: 21803580
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts.
    Walter K; Omura N; Hong SM; Griffith M; Vincent A; Borges M; Goggins M
    Clin Cancer Res; 2010 Mar; 16(6):1781-9. PubMed ID: 20215540
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth.
    Remsberg JR; Lou H; Tarasov SG; Dean M; Tarasova NI
    J Med Chem; 2007 Sep; 50(18):4534-8. PubMed ID: 17685505
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?
    Ruiz i Altaba A
    Cancer Cell; 2008 Oct; 14(4):281-3. PubMed ID: 18835029
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.