These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 20595032)

  • 21. Antimalarial activity of prodrugs of N-branched acyclic nucleoside phosphonate inhibitors of 6-oxopurine phosphoribosyltransferases.
    Hocková D; Janeba Z; Naesens L; Edstein MD; Chavchich M; Keough DT; Guddat LW
    Bioorg Med Chem; 2015 Sep; 23(17):5502-10. PubMed ID: 26275679
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
    Shi W; Li CM; Tyler PC; Furneaux RH; Cahill SM; Girvin ME; Grubmeyer C; Schramm VL; Almo SC
    Biochemistry; 1999 Aug; 38(31):9872-80. PubMed ID: 10433693
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Synthesis and Evaluation of Novel Acyclic Nucleoside Phosphonates as Inhibitors of Plasmodium falciparum and Human 6-Oxopurine Phosphoribosyltransferases.
    Kaiser MM; Hocková D; Wang TH; Dračínský M; Poštová-Slavětínská L; Procházková E; Edstein MD; Chavchich M; Keough DT; Guddat LW; Janeba Z
    ChemMedChem; 2015 Oct; 10(10):1707-23. PubMed ID: 26368337
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.
    Klejch T; Keough DT; Chavchich M; Travis J; Skácel J; Pohl R; Janeba Z; Edstein MD; Avery VM; Guddat LW; Hocková D
    Eur J Med Chem; 2019 Dec; 183():111667. PubMed ID: 31536893
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.
    Welin M; Egeblad L; Johansson A; Stenmark P; Wang L; Flodin S; Nyman T; Trésaugues L; Kotenyova T; Johansson I; Eriksson S; Eklund H; Nordlund P
    FEBS J; 2010 Dec; 277(23):4920-30. PubMed ID: 21054786
    [TBL] [Abstract][Full Text] [Related]  

  • 26. A single amino acid substitution in the human and a bacterial hypoxanthine phosphoribosyltransferase modulates specificity for the binding of guanine.
    Lee CC; Craig SP; Eakin AE
    Biochemistry; 1998 Mar; 37(10):3491-8. PubMed ID: 9521670
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization.
    Gayathri P; Sujay Subbayya IN; Ashok CS; Selvi TS; Balaram H; Murthy MR
    Proteins; 2008 Dec; 73(4):1010-20. PubMed ID: 18536021
    [TBL] [Abstract][Full Text] [Related]  

  • 28. A non-active site mutation in human hypoxanthine guanine phosphoribosyltransferase expands substrate specificity.
    Raman J; Sumathy K; Anand RP; Balaram H
    Arch Biochem Biophys; 2004 Jul; 427(1):116-22. PubMed ID: 15178494
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning, expression, and biochemical characterization.
    Biazus G; Schneider CZ; Palma MS; Basso LA; Santos DS
    Protein Expr Purif; 2009 Aug; 66(2):185-90. PubMed ID: 19362594
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Hypoxanthine guanine phosphoribosyltransferase distorts the purine ring of nucleotide substrates and perturbs the pKa of bound xanthosine monophosphate.
    Gogia S; Balaram H; Puranik M
    Biochemistry; 2011 May; 50(19):4184-93. PubMed ID: 21486037
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Purification of human malaria parasite hypoxanthine guanine xanthine phosphoribosyltransferase (HGXPRT) using immobilized Reactive Red 120.
    Mbewe B; Chibale K; McIntosh DB
    Protein Expr Purif; 2007 Mar; 52(1):153-8. PubMed ID: 17097304
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Biochemical characterization of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphorybosyltransferase: role of histidine residue in substrate selectivity.
    Sarkar D; Ghosh I; Datta S
    Mol Biochem Parasitol; 2004 Oct; 137(2):267-76. PubMed ID: 15383297
    [TBL] [Abstract][Full Text] [Related]  

  • 33. A comparative QM/MM simulation study of the reaction mechanisms of human and Plasmodium falciparum HG(X)PRTases.
    Thomas A; Field MJ
    J Am Chem Soc; 2006 Aug; 128(31):10096-102. PubMed ID: 16881638
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
    Frydrych J; Keough DT; Chavchich M; Travis J; Dračínský M; Edstein MD; Guddat LW; Hocková D; Janeba Z
    Eur J Med Chem; 2021 Jul; 219():113416. PubMed ID: 33887682
    [TBL] [Abstract][Full Text] [Related]  

  • 35. N2'-Branched Acyclic Nucleoside Phosphonates Containing 9-Deazahypoxanthine as Inhibitors of Plasmodium falciparum 6-Oxopurine Phosphoribosyltransferase.
    Vaňková K; Keough DT; Hocková D; Guddat LW; Janeba Z
    ChemMedChem; 2023 Aug; 18(15):e202300211. PubMed ID: 37264975
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Cloning, purification, and characterization of thermostable hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis.
    Chen Q; You D; Hu M; Gu X; Luo M; Lu S
    Protein Expr Purif; 2003 Dec; 32(2):239-45. PubMed ID: 14965769
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery.
    Doleželová E; Terán D; Gahura O; Kotrbová Z; Procházková M; Keough D; Špaček P; Hocková D; Guddat L; Zíková A
    PLoS Negl Trop Dis; 2018 Feb; 12(2):e0006301. PubMed ID: 29481567
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases.
    Li CM; Tyler PC; Furneaux RH; Kicska G; Xu Y; Grubmeyer C; Girvin ME; Schramm VL
    Nat Struct Biol; 1999 Jun; 6(6):582-7. PubMed ID: 10360365
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Expression and properties of recombinant P. falciparum hypoxanthine-guanine phosphoribosyltransferase.
    Keough DT; Ng AL; Emmerson BT; de Jersey J
    Adv Exp Med Biol; 1998; 431():735-9. PubMed ID: 9598161
    [No Abstract]   [Full Text] [Related]  

  • 40. Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis.
    Page JP; Munagala NR; Wang CC
    Eur J Biochem; 1999 Feb; 259(3):565-71. PubMed ID: 10092838
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 8.