148 related articles for article (PubMed ID: 20599933)
1. Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
Hájek M; Cvilink V; Votruba I; Holý A; Mertlíková-Kaiserová H
Eur J Pharmacol; 2010 Sep; 643(1):6-12. PubMed ID: 20599933
[TBL] [Abstract][Full Text] [Related]
2. Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
Mertlíková-Kaiserová H; Nejedlá M; Holy A; Votruba I
Anticancer Res; 2012 Feb; 32(2):497-501. PubMed ID: 22287737
[TBL] [Abstract][Full Text] [Related]
3. 9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).
Compton ML; Toole JJ; Paborsky LR
Biochem Pharmacol; 1999 Aug; 58(4):709-14. PubMed ID: 10413310
[TBL] [Abstract][Full Text] [Related]
4. Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Mertlíková-Kaiserová H; Rumlová M; Tloušťová E; Procházková E; Holý A; Votruba I
Biochem Pharmacol; 2011 Jul; 82(2):131-8. PubMed ID: 21515241
[TBL] [Abstract][Full Text] [Related]
5. 9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Naesens L; Hatse S; Segers C; Verbeken E; De Clercq E; Waer M; Balzarini J
Oncol Res; 1999; 11(4):195-203. PubMed ID: 10566618
[TBL] [Abstract][Full Text] [Related]
6. Genistein induces cell growth inhibition in prostate cancer through the suppression of telomerase activity.
Ouchi H; Ishiguro H; Ikeda N; Hori M; Kubota Y; Uemura H
Int J Urol; 2005 Jan; 12(1):73-80. PubMed ID: 15661057
[TBL] [Abstract][Full Text] [Related]
7. Arsenic induces telomerase expression and maintains telomere length in human cord blood cells.
Ferrario D; Collotta A; Carfi M; Bowe G; Vahter M; Hartung T; Gribaldo L
Toxicology; 2009 Jun; 260(1-3):132-41. PubMed ID: 19464579
[TBL] [Abstract][Full Text] [Related]
8. Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells.
Jagadeesh S; Kyo S; Banerjee PP
Cancer Res; 2006 Feb; 66(4):2107-15. PubMed ID: 16489011
[TBL] [Abstract][Full Text] [Related]
9. N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
Hatse S; Naesens L; De Clercq E; Balzarini J
Biochem Pharmacol; 1999 Jul; 58(2):311-23. PubMed ID: 10423173
[TBL] [Abstract][Full Text] [Related]
10. PMEDAP and its N6-substituted derivatives: genotoxic effect and apoptosis in in vitro conditions.
Valeriánová M; Otová B; Bílá V; Hanzalová J; Votruba I; Holý A; Eckschlager T; Krejcí O; Trka J
Anticancer Res; 2003; 23(6C):4933-9. PubMed ID: 14981948
[TBL] [Abstract][Full Text] [Related]
11. Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma.
Valeriánová M; Votruba I; Holy A; Mandys V; Otová B
Anticancer Res; 2001; 21(3B):2057-64. PubMed ID: 11497298
[TBL] [Abstract][Full Text] [Related]
12. Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells.
Binz N; Shalaby T; Rivera P; Shin-ya K; Grotzer MA
Eur J Cancer; 2005 Dec; 41(18):2873-81. PubMed ID: 16253503
[TBL] [Abstract][Full Text] [Related]
13. Cyclic induction of senescence with intermittent AZT treatment accelerates both apoptosis and telomere loss.
Ji HJ; Rha SY; Jeung HC; Yang SH; An SW; Chung HC
Breast Cancer Res Treat; 2005 Oct; 93(3):227-36. PubMed ID: 16132531
[TBL] [Abstract][Full Text] [Related]
14. Elevated telomerase activity, c-MYC-, and hTERT mRNA expression: association with tumour progression in malignant lipomatous tumours.
Schneider-Stock R; Boltze C; Jäger V; Epplen J; Landt O; Peters B; Rys J; Roessner A
J Pathol; 2003 Apr; 199(4):517-25. PubMed ID: 12635143
[TBL] [Abstract][Full Text] [Related]
15. Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity.
Ducrest AL; Amacker M; Mathieu YD; Cuthbert AP; Trott DA; Newbold RF; Nabholz M; Lingner J
Cancer Res; 2001 Oct; 61(20):7594-602. PubMed ID: 11606399
[TBL] [Abstract][Full Text] [Related]
16. Role of caspases and CD95/Fas in the apoptotic effects of a nucleotide analog PMEG in CCRF-CEM cells.
Mertlíková-Kaiserová H; Votruba I; Matousová M; Holy A; Hájek M
Anticancer Res; 2010 Jul; 30(7):2791-8. PubMed ID: 20683014
[TBL] [Abstract][Full Text] [Related]
17. In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
Otová B; Hrdy J; Votruba I; Holy A
Anticancer Res; 2009 Apr; 29(4):1295-302. PubMed ID: 19414378
[TBL] [Abstract][Full Text] [Related]
18. Amplification of hTERT and hTERC genes in leukemic cells with high expression and activity of telomerase.
Nowak T; Januszkiewicz D; Zawada M; Pernak M; Lewandowski K; Rembowska J; Nowicka K; Mankowski P; Nowak J
Oncol Rep; 2006 Aug; 16(2):301-5. PubMed ID: 16820907
[TBL] [Abstract][Full Text] [Related]
19. Telomerase inhibition is a specific early event in salvicine-treated human lung adenocarcinoma A549 cells.
Liu WJ; Zhang YW; Shen Y; Jiang JF; Miao ZH; Ding J
Biochem Biophys Res Commun; 2004 Oct; 323(2):660-7. PubMed ID: 15369801
[TBL] [Abstract][Full Text] [Related]
20. Telomerase activity level, but not hTERT mRNA and hTR level, regulates telomere length in telomerase-reconstituted primary fibroblasts.
Swiggers SJ; Nibbeling HA; Zeilemaker A; Kuijpers MA; Mattern KA; Zijlmans JM
Exp Cell Res; 2004 Jul; 297(2):434-43. PubMed ID: 15212946
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]