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2. Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models. Ferrer I; Barrachina M; Puig B; Martínez de Lagrán M; Martí E; Avila J; Dierssen M Neurobiol Dis; 2005 Nov; 20(2):392-400. PubMed ID: 16242644 [TBL] [Abstract][Full Text] [Related]
3. Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer's disease. Ryoo SR; Cho HJ; Lee HW; Jeong HK; Radnaabazar C; Kim YS; Kim MJ; Son MY; Seo H; Chung SH; Song WJ J Neurochem; 2008 Mar; 104(5):1333-44. PubMed ID: 18005339 [TBL] [Abstract][Full Text] [Related]
4. Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice. Mazur-Kolecka B; Golabek A; Kida E; Rabe A; Hwang YW; Adayev T; Wegiel J; Flory M; Kaczmarski W; Marchi E; Frackowiak J J Neurosci Res; 2012 May; 90(5):999-1010. PubMed ID: 22252917 [TBL] [Abstract][Full Text] [Related]
5. The spatio-temporal and subcellular expression of the candidate Down syndrome gene Mnb/Dyrk1A in the developing mouse brain suggests distinct sequential roles in neuronal development. Hämmerle B; Elizalde C; Tejedor FJ Eur J Neurosci; 2008 Mar; 27(5):1061-74. PubMed ID: 18364031 [TBL] [Abstract][Full Text] [Related]
7. Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis. Kim Y; Park J; Song WJ; Chang S Neurosignals; 2010; 18(3):164-72. PubMed ID: 21135538 [TBL] [Abstract][Full Text] [Related]
8. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Altafaj X; Martín ED; Ortiz-Abalia J; Valderrama A; Lao-Peregrín C; Dierssen M; Fillat C Neurobiol Dis; 2013 Apr; 52():117-27. PubMed ID: 23220201 [TBL] [Abstract][Full Text] [Related]
9. Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome. Hijazi M; Fillat C; Medina JM; Velasco A Exp Neurol; 2013 Jan; 239():229-34. PubMed ID: 23124096 [TBL] [Abstract][Full Text] [Related]
10. Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes. García-Cerro S; Rueda N; Vidal V; Lantigua S; Martínez-Cué C Neurobiol Dis; 2017 Oct; 106():76-88. PubMed ID: 28647555 [TBL] [Abstract][Full Text] [Related]
11. Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease. Ryu YS; Park SY; Jung MS; Yoon SH; Kwen MY; Lee SY; Choi SH; Radnaabazar C; Kim MK; Kim H; Kim K; Song WJ; Chung SH J Neurochem; 2010 Nov; 115(3):574-84. PubMed ID: 20456003 [TBL] [Abstract][Full Text] [Related]
12. Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons. Martinez de Lagran M; Benavides-Piccione R; Ballesteros-Yañez I; Calvo M; Morales M; Fillat C; Defelipe J; Ramakers GJ; Dierssen M Cereb Cortex; 2012 Dec; 22(12):2867-77. PubMed ID: 22215728 [TBL] [Abstract][Full Text] [Related]
13. Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Altafaj X; Ortiz-Abalia J; Fernández M; Potier MC; Laffaire J; Andreu N; Dierssen M; González-García C; Ceña V; Martí E; Fillat C Neurobiol Dis; 2008 Dec; 32(3):377-84. PubMed ID: 18773961 [TBL] [Abstract][Full Text] [Related]
14. The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Kimura R; Kamino K; Yamamoto M; Nuripa A; Kida T; Kazui H; Hashimoto R; Tanaka T; Kudo T; Yamagata H; Tabara Y; Miki T; Akatsu H; Kosaka K; Funakoshi E; Nishitomi K; Sakaguchi G; Kato A; Hattori H; Uema T; Takeda M Hum Mol Genet; 2007 Jan; 16(1):15-23. PubMed ID: 17135279 [TBL] [Abstract][Full Text] [Related]
15. Abnormal mineralization of the Ts65Dn Down syndrome mouse appendicular skeleton begins during embryonic development in a Dyrk1a-independent manner. Blazek JD; Malik AM; Tischbein M; Arbones ML; Moore CS; Roper RJ Mech Dev; 2015 May; 136():133-42. PubMed ID: 25556111 [TBL] [Abstract][Full Text] [Related]
16. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Laguna A; Barallobre MJ; Marchena MÁ; Mateus C; Ramírez E; Martínez-Cue C; Delabar JM; Castelo-Branco M; de la Villa P; Arbonés ML Hum Mol Genet; 2013 Jul; 22(14):2775-84. PubMed ID: 23512985 [TBL] [Abstract][Full Text] [Related]
17. Generation of improved human cerebral organoids from single copy DYRK1A knockout induced pluripotent stem cells in trisomy 21: hypothetical solutions for neurodevelopmental models and therapeutic alternatives in down syndrome. Çağlayan ES Cell Biol Int; 2016 Dec; 40(12):1256-1270. PubMed ID: 27743462 [TBL] [Abstract][Full Text] [Related]
18. Cbs overdosage is necessary and sufficient to induce cognitive phenotypes in mouse models of Down syndrome and interacts genetically with Dyrk1a. Marechal D; Brault V; Leon A; Martin D; Lopes Pereira P; Loaëc N; Birling MC; Friocourt G; Blondel M; Herault Y Hum Mol Genet; 2019 May; 28(9):1561-1577. PubMed ID: 30649339 [TBL] [Abstract][Full Text] [Related]
19. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Yin X; Jin N; Shi J; Zhang Y; Wu Y; Gong CX; Iqbal K; Liu F Sci Rep; 2017 Apr; 7(1):619. PubMed ID: 28377597 [TBL] [Abstract][Full Text] [Related]
20. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. Canzonetta C; Mulligan C; Deutsch S; Ruf S; O'Doherty A; Lyle R; Borel C; Lin-Marq N; Delom F; Groet J; Schnappauf F; De Vita S; Averill S; Priestley JV; Martin JE; Shipley J; Denyer G; Epstein CJ; Fillat C; Estivill X; Tybulewicz VL; Fisher EM; Antonarakis SE; Nizetic D Am J Hum Genet; 2008 Sep; 83(3):388-400. PubMed ID: 18771760 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]