These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

266 related articles for article (PubMed ID: 20601018)

  • 1. Assessing use-dependent inhibition of the cardiac Na(+/-) current (I(Na)) in the PatchXpress automated patch clamp.
    Penniman JR; Kim DC; Salata JJ; Imredy JP
    J Pharmacol Toxicol Methods; 2010; 62(2):107-18. PubMed ID: 20601018
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Translation of flecainide- and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical.
    Heath BM; Cui Y; Worton S; Lawton B; Ward G; Ballini E; Doe CP; Ellis C; Patel BA; McMahon NC
    J Pharmacol Toxicol Methods; 2011; 63(3):258-68. PubMed ID: 21194571
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation.
    Aoike F; Takahashi MP; Sakoda S
    Eur J Pharmacol; 2006 Feb; 532(1-2):24-31. PubMed ID: 16473348
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block.
    Desaphy JF; De Luca A; Didonna MP; George AL; Camerino Conte D
    J Physiol; 2004 Jan; 554(Pt 2):321-34. PubMed ID: 14608015
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine.
    Wang Y; Mi J; Lu K; Lu Y; Wang K
    PLoS One; 2015; 10(6):e0128653. PubMed ID: 26068619
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation.
    Guo L; Guthrie H
    J Pharmacol Toxicol Methods; 2005; 52(1):123-35. PubMed ID: 15936217
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Application of PatchXpress planar patch clamp technology to the screening of new drug candidates for cardiac KCNQ1/KCNE1 (I Ks) activity.
    Trepakova ES; Malik MG; Imredy JP; Penniman JR; Dech SJ; Salata JJ
    Assay Drug Dev Technol; 2007 Oct; 5(5):617-27. PubMed ID: 17939752
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.
    Wang GK; Russell C; Wang SY
    J Physiol; 2004 Feb; 554(Pt 3):621-33. PubMed ID: 14608007
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.
    Sasaki K; Makita N; Sunami A; Sakurada H; Shirai N; Yokoi H; Kimura A; Tohse N; Hiraoka M; Kitabatake A
    Mol Pharmacol; 2004 Aug; 66(2):330-6. PubMed ID: 15266024
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.
    Desaphy JF; Dipalma A; Costanza T; Bruno C; Lentini G; Franchini C; George A; Conte Camerino D
    Br J Pharmacol; 2010 Jul; 160(6):1521-33. PubMed ID: 20590641
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Properties of voltage-gated Na+ channels in the human rhabdomyosarcoma cell-line SJ-RH30: conventional and automated patch clamp analysis.
    Randall A; McNaughton N; Green P
    Pharmacol Res; 2006 Aug; 54(2):118-28. PubMed ID: 16675265
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Optimisation and validation of a medium-throughput electrophysiology-based hNav1.5 assay using IonWorks.
    Harmer AR; Abi-Gerges N; Easter A; Woods A; Lawrence CL; Small BG; Valentin JP; Pollard CE
    J Pharmacol Toxicol Methods; 2008; 57(1):30-41. PubMed ID: 17980627
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Action potential changes associated with a slowed inactivation of cardiac voltage-gated sodium channels by KB130015.
    Macianskiene R; Bito V; Raeymaekers L; Brandts B; Sipido KR; Mubagwa K
    Br J Pharmacol; 2003 Aug; 139(8):1469-79. PubMed ID: 12922934
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Expression of skeletal but not cardiac Na+ channel isoform preserves normal conduction in a depolarized cardiac syncytium.
    Protas L; Dun W; Jia Z; Lu J; Bucchi A; Kumari S; Chen M; Cohen IS; Rosen MR; Entcheva E; Robinson RB
    Cardiovasc Res; 2009 Feb; 81(3):528-35. PubMed ID: 18977767
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The comparative sensitivity of three in vitro safety pharmacology models for the detection of lidocaine-induced cardiac effects.
    Goineau S; Castagné V; Guillaume P; Froget G
    J Pharmacol Toxicol Methods; 2012 Jul; 66(1):52-8. PubMed ID: 22691624
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Common molecular determinants of flecainide and lidocaine block of heart Na+ channels: evidence from experiments with neutral and quaternary flecainide analogues.
    Liu H; Atkins J; Kass RS
    J Gen Physiol; 2003 Mar; 121(3):199-214. PubMed ID: 12601084
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay.
    Qu Y; Gao B; Fang M; Vargas HM
    J Pharmacol Toxicol Methods; 2013; 68(1):74-81. PubMed ID: 23518063
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
    Belardinelli L; Liu G; Smith-Maxwell C; Wang WQ; El-Bizri N; Hirakawa R; Karpinski S; Li CH; Hu L; Li XJ; Crumb W; Wu L; Koltun D; Zablocki J; Yao L; Dhalla AK; Rajamani S; Shryock JC
    J Pharmacol Exp Ther; 2013 Jan; 344(1):23-32. PubMed ID: 23010360
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Use-dependent block by lidocaine but not amitriptyline is more pronounced in tetrodotoxin (TTX)-Resistant Nav1.8 than in TTX-sensitive Na+ channels.
    Leffler A; Reiprich A; Mohapatra DP; Nau C
    J Pharmacol Exp Ther; 2007 Jan; 320(1):354-64. PubMed ID: 17005919
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Blocking effect of methylflavonolamine on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes.
    Fan XR; Ma JH; Zhang PH; Xing JL
    Acta Pharmacol Sin; 2010 Mar; 31(3):297-306. PubMed ID: 20173760
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.