BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 20609366)

  • 1. Crystal structure of leukotriene A4 hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors.
    Tholander F; Roques BP; Fournié-Zaluski MC; Thunnissen MM; Haeggström JZ
    FEBS Lett; 2010 Aug; 584(15):3446-51. PubMed ID: 20609366
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Aminopeptidase B is structurally related to leukotriene-A4 hydrolase but is not a bifunctional enzyme with epoxide hydrolase activity.
    Fukasawa KM; Fukasawa K; Harada M; Hirose J; Izumi T; Shimizu T
    Biochem J; 1999 May; 339 ( Pt 3)(Pt 3):497-502. PubMed ID: 10215585
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.
    Thunnissen MM; Nordlund P; Haeggström JZ
    Nat Struct Biol; 2001 Feb; 8(2):131-5. PubMed ID: 11175901
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design.
    Tholander F; Muroya A; Roques BP; Fournié-Zaluski MC; Thunnissen MM; Haeggström JZ
    Chem Biol; 2008 Sep; 15(9):920-9. PubMed ID: 18804029
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
    Numao S; Hasler F; Laguerre C; Srinivas H; Wack N; Jäger P; Schmid A; Osmont A; Röthlisberger P; Houguenade J; Bergsdorf C; Dawson J; Carte N; Hofmann A; Markert C; Hardaker L; Billich A; Wolf RM; Penno CA; Bollbuck B; Miltz W; Röhn TA
    Sci Rep; 2017 Oct; 7(1):13591. PubMed ID: 29051536
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.
    Rudberg PC; Tholander F; Andberg M; Thunnissen MM; Haeggström JZ
    J Biol Chem; 2004 Jun; 279(26):27376-82. PubMed ID: 15078870
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase.
    Bauvois C; Jacquamet L; Huston AL; Borel F; Feller G; Ferrer JL
    J Biol Chem; 2008 Aug; 283(34):23315-25. PubMed ID: 18539590
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dual anti-inflammatory and selective inhibition mechanism of leukotriene A4 hydrolase/aminopeptidase: insights from comparative molecular dynamics and binding free energy analyses.
    Appiah-Kubi P; Soliman ME
    J Biomol Struct Dyn; 2016 Nov; 34(11):2418-33. PubMed ID: 26555301
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding.
    Helgstrand C; Hasan M; Uysal H; Haeggström JZ; Thunnissen MM
    J Mol Biol; 2011 Feb; 406(1):120-34. PubMed ID: 21146536
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors.
    Thunnissen MM; Andersson B; Samuelsson B; Wong CH; Haeggström J
    FASEB J; 2002 Oct; 16(12):1648-50. PubMed ID: 12207002
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Hybrid Receptor-Bound/MM-GBSA-Per-residue Energy-Based Pharmacophore Modelling: Enhanced Approach for Identification of Selective LTA4H Inhibitors as Potential Anti-inflammatory Drugs.
    Appiah-Kubi P; Soliman M
    Cell Biochem Biophys; 2017 Mar; 75(1):35-48. PubMed ID: 27914004
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Capturing LTA
    Stsiapanava A; Samuelsson B; Haeggström JZ
    Proc Natl Acad Sci U S A; 2017 Sep; 114(36):9689-9694. PubMed ID: 28827365
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.
    Rudberg PC; Tholander F; Thunnissen MM; Haeggström JZ
    J Biol Chem; 2002 Jan; 277(2):1398-404. PubMed ID: 11675384
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Asparagine362 is essential for zinc binding and catalysis in the peptidase reaction of Saccharomyces cerevisiae leukotriene A₄ hydrolase.
    Seipelt RL; Bailey FC; Schaible A; Thompson MW
    Biochim Biophys Acta; 2010 Oct; 1804(10):2070-6. PubMed ID: 20624488
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis.
    Peng G; McEwen AG; Olieric V; Schmitt C; Albrecht S; Cavarelli J; Tarnus C
    Proteins; 2017 Aug; 85(8):1413-1421. PubMed ID: 28383176
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling.
    Pham VL; Cadel MS; Gouzy-Darmon C; Hanquez C; Beinfeld MC; Nicolas P; Etchebest C; Foulon T
    BMC Biochem; 2007 Oct; 8():21. PubMed ID: 17974014
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase.
    Díaz-Perales A; Quesada V; Sánchez LM; Ugalde AP; Suárez MF; Fueyo A; López-Otín C
    J Biol Chem; 2005 Apr; 280(14):14310-7. PubMed ID: 15687497
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.
    Toh H; Minami M; Shimizu T
    Biochem Biophys Res Commun; 1990 Aug; 171(1):216-21. PubMed ID: 1975494
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin.
    Andberg M; Wetterholm A; Medina JF; Haeggström JZ
    Biochem J; 2000 Feb; 345 Pt 3(Pt 3):621-5. PubMed ID: 10642521
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.
    Kyrieleis OJ; Goettig P; Kiefersauer R; Huber R; Brandstetter H
    J Mol Biol; 2005 Jun; 349(4):787-800. PubMed ID: 15893768
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.