130 related articles for article (PubMed ID: 20615712)
1. Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.
Franks A; Tronrud C; Kiakos K; Kluza J; Munde M; Brown T; Mackay H; Wilson WD; Hochhauser D; Hartley JA; Lee M
Bioorg Med Chem; 2010 Aug; 18(15):5553-61. PubMed ID: 20615712
[TBL] [Abstract][Full Text] [Related]
2. Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
Henry JA; Le NM; Nguyen B; Howard CM; Bailey SL; Horick SM; Buchmueller KL; Kotecha M; Hochhauser D; Hartley JA; Wilson WD; Lee M
Biochemistry; 2004 Sep; 43(38):12249-57. PubMed ID: 15379563
[TBL] [Abstract][Full Text] [Related]
3. Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.
Mackay H; Brown T; Uthe PB; Westrate L; Sielaff A; Jones J; Lajiness JP; Kluza J; O'Hare C; Nguyen B; Davis Z; Bruce C; Wilson WD; Hartley JA; Lee M
Bioorg Med Chem; 2008 Oct; 16(20):9145-53. PubMed ID: 18819814
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and evaluation of an intercalator-polyamide hairpin designed to target the inverted CCAAT box 2 in the topoisomerase IIalpha promoter.
Flores LV; Staples AM; Mackay H; Howard CM; Uthe PB; Sexton JS; Buchmueller KL; Wilson WD; O'Hare C; Kluza J; Hochhauser D; Hartley JA; Lee M
Chembiochem; 2006 Nov; 7(11):1722-9. PubMed ID: 16991167
[TBL] [Abstract][Full Text] [Related]
5. Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells.
Le NM; Sielaff AM; Cooper AJ; Mackay H; Brown T; Kotecha M; O'Hare C; Hochhauser D; Lee M; Hartley JA
Bioorg Med Chem Lett; 2006 Dec; 16(24):6161-4. PubMed ID: 17011187
[TBL] [Abstract][Full Text] [Related]
6. Design, synthesis, and DNA binding characteristics of a group of orthogonally positioned diamino, N-formamido, pyrrole- and imidazole-containing polyamides.
Chavda S; Babu B; Patil P; Plaunt A; Ferguson A; Lee M; Tzou S; Sjoholm R; Rice T; Mackay H; Ramos J; Wang S; Lin S; Kiakos K; Wilson WD; Hartley JA; Lee M
Bioorg Med Chem; 2013 Jul; 21(13):3907-18. PubMed ID: 23647824
[TBL] [Abstract][Full Text] [Related]
7. Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.
Pett L; Kiakos K; Satam V; Patil P; Laughlin-Toth S; Gregory M; Bowerman M; Olson K; Savagian M; Lee M; Lee M; Wilson WD; Hochhauser D; Hartley JA
Biochim Biophys Acta Gene Regul Mech; 2017 May; 1860(5):617-629. PubMed ID: 27750031
[TBL] [Abstract][Full Text] [Related]
8. Effects of the N-terminal acylamido group of imidazole- and pyrrole-containing polyamides on DNA sequence specificity and binding affinity.
Westrate L; Mackay H; Brown T; Nguyen B; Kluza J; Wilson WD; Lee M; Hartley JA
Biochemistry; 2009 Jun; 48(24):5679-88. PubMed ID: 19419200
[TBL] [Abstract][Full Text] [Related]
9. Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
O'Hare CC; Uthe P; Mackay H; Blackmon K; Jones J; Brown T; Nguyen B; Wilson WD; Lee M; Hartley JA
Biochemistry; 2007 Oct; 46(42):11661-70. PubMed ID: 17910471
[TBL] [Abstract][Full Text] [Related]
10. Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide.
Kiakos K; Pett L; Satam V; Patil P; Hochhauser D; Lee M; Hartley JA
Chem Biol; 2015 Jul; 22(7):862-75. PubMed ID: 26119998
[TBL] [Abstract][Full Text] [Related]
11. Hx, a novel fluorescent, minor groove and sequence specific recognition element: design, synthesis, and DNA binding properties of p-anisylbenzimidazole-imidazole/pyrrole-containing polyamides.
Chavda S; Liu Y; Babu B; Davis R; Sielaff A; Ruprich J; Westrate L; Tronrud C; Ferguson A; Franks A; Tzou S; Adkins C; Rice T; Mackay H; Kluza J; Tahir SA; Lin S; Kiakos K; Bruce CD; Wilson WD; Hartley JA; Lee M
Biochemistry; 2011 Apr; 50(15):3127-36. PubMed ID: 21388229
[TBL] [Abstract][Full Text] [Related]
12. Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.
Mackay H; Brown T; Sexton JS; Kotecha M; Nguyen B; Wilson WD; Kluza J; Savic B; O'Hare C; Hochhauser D; Lee M; Hartley JA
Bioorg Med Chem; 2008 Feb; 16(4):2093-102. PubMed ID: 17977733
[TBL] [Abstract][Full Text] [Related]
13. Novel diamino imidazole and pyrrole-containing polyamides: Synthesis and DNA binding studies of mono- and diamino-phenyl-ImPy*Im polyamides designed to target 5'-ACGCGT-3'.
Satam V; Babu B; Chavda S; Savagian M; Sjoholm R; Tzou S; Ramos J; Liu Y; Kiakos K; Lin S; David Wilson W; Hartley JA; Lee M
Bioorg Med Chem; 2012 Jan; 20(2):693-701. PubMed ID: 22222156
[TBL] [Abstract][Full Text] [Related]
14. Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene.
Buchmueller KL; Taherbhai Z; Howard CM; Bailey SL; Nguyen B; O'Hare C; Hochhauser D; Hartley JA; Wilson WD; Lee M
Chembiochem; 2005 Dec; 6(12):2305-11. PubMed ID: 16254941
[TBL] [Abstract][Full Text] [Related]
15. AzaHx, a novel fluorescent, DNA minor groove and G·C recognition element: Synthesis and DNA binding properties of a p-anisyl-4-aza-benzimidazole-pyrrole-imidazole (azaHx-PI) polyamide.
Satam V; Babu B; Patil P; Brien KA; Olson K; Savagian M; Lee M; Mepham A; Jobe LB; Bingham JP; Pett L; Wang S; Ferrara M; Bruce CD; Wilson WD; Lee M; Hartley JA; Kiakos K
Bioorg Med Chem Lett; 2015 Sep; 25(17):3681-5. PubMed ID: 26122210
[TBL] [Abstract][Full Text] [Related]
16. Influence of a terminal formamido group on the sequence recognition of DNA by polyamides.
Lacy ER; Le NM; Price CA; Lee M; Wilson WD
J Am Chem Soc; 2002 Mar; 124(10):2153-63. PubMed ID: 11878969
[TBL] [Abstract][Full Text] [Related]
17. Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide.
Hochhauser D; Kotecha M; O'hare C; Morris PJ; Hartley JM; Taherbhai Z; Harris D; Forni C; Mantovani R; Lee M; Hartley JA
Mol Cancer Ther; 2007 Jan; 6(1):346-54. PubMed ID: 17237293
[TBL] [Abstract][Full Text] [Related]
18. A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
Ueno T; Fukuda N; Tsunemi A; Yao EH; Matsuda H; Tahira K; Matsumoto T; Matsumoto K; Matsumoto Y; Nagase H; Sugiyama H; Sawamura T
J Hypertens; 2009 Mar; 27(3):508-16. PubMed ID: 19330905
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis and DNA binding properties of orthogonally positioned diamino containing polyamide f-IPI.
Babu B; Liu Y; Plaunt A; Riddering C; Ogilvie R; Westrate L; Davis R; Ferguson A; Mackay H; Rice T; Chavda S; Wilson D; Lin S; Kiakos K; Hartley JA; Lee M
Biochem Biophys Res Commun; 2011 Jan; 404(3):848-52. PubMed ID: 21185262
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin.
Brown T; Taherbhai Z; Sexton J; Sutterfield A; Turlington M; Jones J; Stallings L; Stewart M; Buchmueller K; Mackay H; O'hare C; Kluza J; Nguyen B; Wilson D; Lee M; Hartley JA
Bioorg Med Chem; 2007 Jan; 15(1):474-83. PubMed ID: 17035029
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
