BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 20621636)

  • 1. Expression and characterization of Mycobacterium tuberculosis CYP144: common themes and lessons learned in the M. tuberculosis P450 enzyme family.
    Driscoll MD; McLean KJ; Cheesman MR; Jowitt TA; Howard M; Carroll P; Parish T; Munro AW
    Biochim Biophys Acta; 2011 Jan; 1814(1):76-87. PubMed ID: 20621636
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs.
    Ouellet H; Podust LM; de Montellano PR
    J Biol Chem; 2008 Feb; 283(8):5069-80. PubMed ID: 18089574
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biophysical characterization of the sterol demethylase P450 from Mycobacterium tuberculosis, its cognate ferredoxin, and their interactions.
    McLean KJ; Warman AJ; Seward HE; Marshall KR; Girvan HM; Cheesman MR; Waterman MR; Munro AW
    Biochemistry; 2006 Jul; 45(27):8427-43. PubMed ID: 16819841
    [TBL] [Abstract][Full Text] [Related]  

  • 4. CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: towards deconvoluting enzymology of P450 systems in a human pathogen.
    McLean KJ; Dunford AJ; Sabri M; Neeli R; Girvan HM; Balding PR; Leys D; Seward HE; Marshall KR; Munro AW
    Biochem Soc Trans; 2006 Dec; 34(Pt 6):1178-82. PubMed ID: 17073780
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expression, purification and spectroscopic characterization of the cytochrome P450 CYP121 from Mycobacterium tuberculosis.
    McLean KJ; Cheesman MR; Rivers SL; Richmond A; Leys D; Chapman SK; Reid GA; Price NC; Kelly SM; Clarkson J; Smith WE; Munro AW
    J Inorg Biochem; 2002 Sep; 91(4):527-41. PubMed ID: 12237220
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Rapid P450 heme iron reduction by laser photoexcitation of Mycobacterium tuberculosis CYP121 and CYP51B1. Analysis of CO complexation reactions and reversibility of the P450/P420 equilibrium.
    Dunford AJ; McLean KJ; Sabri M; Seward HE; Heyes DJ; Scrutton NS; Munro AW
    J Biol Chem; 2007 Aug; 282(34):24816-24. PubMed ID: 17553785
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The Mycobacterium tuberculosis cytochromes P450: physiology, biochemistry & molecular intervention.
    McLean KJ; Belcher J; Driscoll MD; Fernandez CC; Le Van D; Bui S; Golovanova M; Munro AW
    Future Med Chem; 2010 Aug; 2(8):1339-53. PubMed ID: 21426022
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Azole antifungals are potent inhibitors of cytochrome P450 mono-oxygenases and bacterial growth in mycobacteria and streptomycetes.
    McLean KJ; Marshall KR; Richmond A; Hunter IS; Fowler K; Kieser T; Gurcha SS; Besra GS; Munro AW
    Microbiology (Reading); 2002 Oct; 148(Pt 10):2937-2949. PubMed ID: 12368427
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of active site structure in CYP121. A cytochrome P450 essential for viability of Mycobacterium tuberculosis H37Rv.
    McLean KJ; Carroll P; Lewis DG; Dunford AJ; Seward HE; Neeli R; Cheesman MR; Marsollier L; Douglas P; Smith WE; Rosenkrands I; Cole ST; Leys D; Parish T; Munro AW
    J Biol Chem; 2008 Nov; 283(48):33406-16. PubMed ID: 18818197
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Deletion of cyp125 Confers Increased Sensitivity to Azoles in Mycobacterium tuberculosis.
    Carroll P; Parish T
    PLoS One; 2015; 10(7):e0133129. PubMed ID: 26197389
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The preponderance of P450s in the Mycobacterium tuberculosis genome.
    McLean KJ; Clift D; Lewis DG; Sabri M; Balding PR; Sutcliffe MJ; Leys D; Munro AW
    Trends Microbiol; 2006 May; 14(5):220-8. PubMed ID: 16581251
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection.
    McLean KJ; Lafite P; Levy C; Cheesman MR; Mast N; Pikuleva IA; Leys D; Munro AW
    J Biol Chem; 2009 Dec; 284(51):35524-33. PubMed ID: 19846552
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.
    Matsuura K; Yoshioka S; Tosha T; Hori H; Ishimori K; Kitagawa T; Morishima I; Kagawa N; Waterman MR
    J Biol Chem; 2005 Mar; 280(10):9088-96. PubMed ID: 15611056
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets?
    Ortega Ugalde S; Boot M; Commandeur JNM; Jennings P; Bitter W; Vos JC
    Appl Microbiol Biotechnol; 2019 May; 103(9):3597-3614. PubMed ID: 30810776
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide.
    Ouellet H; Lang J; Couture M; Ortiz de Montellano PR
    Biochemistry; 2009 Feb; 48(5):863-72. PubMed ID: 19146393
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1.
    Kavanagh ME; Chenge J; Zoufir A; McLean KJ; Coyne AG; Bender A; Munro AW; Abell C
    Biochemistry; 2017 Mar; 56(11):1559-1572. PubMed ID: 28169518
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from
    Dornevil K; Davis I; Fielding AJ; Terrell JR; Ma L; Liu A
    J Biol Chem; 2017 Aug; 292(33):13645-13657. PubMed ID: 28667013
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis.
    Child SA; Ghith A; Bruning JB; Bell SG
    J Inorg Biochem; 2020 Aug; 209():111116. PubMed ID: 32473484
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1.
    Chenge JT; Duyet LV; Swami S; McLean KJ; Kavanagh ME; Coyne AG; Rigby SE; Cheesman MR; Girvan HM; Levy CW; Rupp B; von Kries JP; Abell C; Leys D; Munro AW
    J Biol Chem; 2017 Jan; 292(4):1310-1329. PubMed ID: 27932461
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids.
    Capyk JK; Kalscheuer R; Stewart GR; Liu J; Kwon H; Zhao R; Okamoto S; Jacobs WR; Eltis LD; Mohn WW
    J Biol Chem; 2009 Dec; 284(51):35534-42. PubMed ID: 19846551
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.