245 related articles for article (PubMed ID: 20622021)
1. CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the development of a metabolically competent human hepatic cell model.
Benet M; Lahoz A; Guzmán C; Castell JV; Jover R
J Biol Chem; 2010 Sep; 285(37):28457-71. PubMed ID: 20622021
[TBL] [Abstract][Full Text] [Related]
2. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
Wang H; Faucette S; Sueyoshi T; Moore R; Ferguson S; Negishi M; LeCluyse EL
J Biol Chem; 2003 Apr; 278(16):14146-52. PubMed ID: 12571232
[TBL] [Abstract][Full Text] [Related]
3. Synergistically enhanced CYP2B6 inducibility between a polymorphic mutation in CYP2B6 promoter and pregnane X receptor activation.
Li H; Ferguson SS; Wang H
Mol Pharmacol; 2010 Oct; 78(4):704-13. PubMed ID: 20624854
[TBL] [Abstract][Full Text] [Related]
4. Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.
Surapureddi S; Rana R; Reddy JK; Goldstein JA
Mol Pharmacol; 2008 Sep; 74(3):913-23. PubMed ID: 18552123
[TBL] [Abstract][Full Text] [Related]
5. Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha.
Inoue K; Negishi M
FEBS Lett; 2009 Jun; 583(12):2126-30. PubMed ID: 19467232
[TBL] [Abstract][Full Text] [Related]
6. Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein α and hepatocyte nuclear factor 4α.
Yang Q; Tang S; Dong L; Chen Q; Liu X; Jiang J; Deng Y
FEBS J; 2014 Mar; 281(5):1379-1392. PubMed ID: 24418194
[TBL] [Abstract][Full Text] [Related]
7. Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.
Wang H; Faucette SR; Gilbert D; Jolley SL; Sueyoshi T; Negishi M; LeCluyse EL
Drug Metab Dispos; 2003 May; 31(5):620-30. PubMed ID: 12695351
[TBL] [Abstract][Full Text] [Related]
8. ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.
Pascual M; Gómez-Lechón MJ; Castell JV; Jover R
Drug Metab Dispos; 2008 Jun; 36(6):1063-72. PubMed ID: 18332083
[TBL] [Abstract][Full Text] [Related]
9. Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene.
Inoue K; Negishi M
J Biol Chem; 2008 Apr; 283(16):10425-32. PubMed ID: 18303024
[TBL] [Abstract][Full Text] [Related]
10. The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.
Wang D; Li L; Fuhrman J; Ferguson S; Wang H
Pharm Res; 2011 Aug; 28(8):2034-44. PubMed ID: 21487929
[TBL] [Abstract][Full Text] [Related]
11. Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.
Koh KH; Jurkovic S; Yang K; Choi SY; Jung JW; Kim KP; Zhang W; Jeong H
Biochem Pharmacol; 2012 Jul; 84(1):93-103. PubMed ID: 22484313
[TBL] [Abstract][Full Text] [Related]
12. Transcriptional activation of CYP2C9, CYP1A1, and CYP1A2 by hepatocyte nuclear factor 4alpha requires coactivators peroxisomal proliferator activated receptor-gamma coactivator 1alpha and steroid receptor coactivator 1.
Martínez-Jiménez CP; Castell JV; Gómez-Lechón MJ; Jover R
Mol Pharmacol; 2006 Nov; 70(5):1681-92. PubMed ID: 16882880
[TBL] [Abstract][Full Text] [Related]
13. Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha.
Ferguson SS; Chen Y; LeCluyse EL; Negishi M; Goldstein JA
Mol Pharmacol; 2005 Sep; 68(3):747-57. PubMed ID: 15933212
[TBL] [Abstract][Full Text] [Related]
14. Ser100-Phosphorylated ROR
Fashe M; Hashiguchi T; Negishi M; Sueyoshi T
Mol Pharmacol; 2020 Mar; 97(3):191-201. PubMed ID: 31924695
[TBL] [Abstract][Full Text] [Related]
15. A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).
Blazquez M; Carretero A; Ellis JK; Athersuch TJ; Cavill R; Ebbels TM; Keun HC; Castell JV; Lahoz A; Bort R
J Proteome Res; 2013 Jun; 12(6):2732-41. PubMed ID: 23641669
[TBL] [Abstract][Full Text] [Related]
16. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
Rhodes SP; Otten JN; Hingorani GP; Hartley DP; Franklin RB
J Pharmacol Toxicol Methods; 2011; 63(3):223-6. PubMed ID: 21111054
[TBL] [Abstract][Full Text] [Related]
17. CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) regulate expression of the human fructose-1,6-bisphosphatase 1 (FBP1) gene in human hepatocellular carcinoma HepG2 cells.
Wattanavanitchakorn S; Rojvirat P; Chavalit T; MacDonald MJ; Jitrapakdee S
PLoS One; 2018; 13(3):e0194252. PubMed ID: 29566023
[TBL] [Abstract][Full Text] [Related]
18. Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels.
Chang TK; Bandiera SM; Chen J
Drug Metab Dispos; 2003 Jan; 31(1):7-10. PubMed ID: 12485946
[TBL] [Abstract][Full Text] [Related]
19. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
[TBL] [Abstract][Full Text] [Related]
20. Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.
Wang H; Faucette S; Moore R; Sueyoshi T; Negishi M; LeCluyse E
J Biol Chem; 2004 Jul; 279(28):29295-301. PubMed ID: 15123723
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]