BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

321 related articles for article (PubMed ID: 2062828)

  • 1. The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
    Noble ME; Wierenga RK; Lambeir AM; Opperdoes FR; Thunnissen AM; Kalk KH; Groendijk H; Hol WG
    Proteins; 1991; 10(1):50-69. PubMed ID: 2062828
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation.
    Verlinde CL; Witmans CJ; Pijning T; Kalk KH; Hol WG; Callens M; Opperdoes FR
    Protein Sci; 1992 Dec; 1(12):1578-84. PubMed ID: 1304889
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase.
    Wierenga RK; Noble ME; Postma JP; Groendijk H; Kalk KH; Hol WG; Opperdoes FR
    Proteins; 1991; 10(1):33-49. PubMed ID: 2062827
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: implications for the reaction mechanism.
    Noble ME; Zeelen JP; Wierenga RK
    Proteins; 1993 Aug; 16(4):311-26. PubMed ID: 8356028
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.
    Wierenga RK; Noble ME; Vriend G; Nauche S; Hol WG
    J Mol Biol; 1991 Aug; 220(4):995-1015. PubMed ID: 1880808
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Crystallographic binding studies with an engineered monomeric variant of triosephosphate isomerase.
    Salin M; Kapetaniou EG; Vaismaa M; Lajunen M; Casteleijn MG; Neubauer P; Salmon L; Wierenga RK
    Acta Crystallogr D Biol Crystallogr; 2010 Aug; 66(Pt 8):934-44. PubMed ID: 20693693
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Solution-state NMR investigations of triosephosphate isomerase active site loop motion: ligand release in relation to active site loop dynamics.
    Rozovsky S; Jogl G; Tong L; McDermott AE
    J Mol Biol; 2001 Jun; 310(1):271-80. PubMed ID: 11419952
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structures of unliganded and inhibitor complexes of W168F, a Loop6 hinge mutant of Plasmodium falciparum triosephosphate isomerase: observation of an intermediate position of loop6.
    Eaazhisai K; Balaram H; Balaram P; Murthy MR
    J Mol Biol; 2004 Oct; 343(3):671-84. PubMed ID: 15465054
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Functional role of the conserved active site proline of triosephosphate isomerase.
    Casteleijn MG; Alahuhta M; Groebel K; El-Sayed I; Augustyns K; Lambeir AM; Neubauer P; Wierenga RK
    Biochemistry; 2006 Dec; 45(51):15483-94. PubMed ID: 17176070
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Crystal structures of triosephosphate isomerase from methicillin resistant Staphylococcus aureus MRSA252 provide structural insights into novel modes of ligand binding and unique conformations of catalytic loop.
    Mukherjee S; Roychowdhury A; Dutta D; Das AK
    Biochimie; 2012 Dec; 94(12):2532-44. PubMed ID: 22813930
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site.
    Gayathri P; Banerjee M; Vijayalakshmi A; Balaram H; Balaram P; Murthy MR
    Acta Crystallogr D Biol Crystallogr; 2009 Aug; 65(Pt 8):847-57. PubMed ID: 19622869
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme.
    Mande SC; Mainfroid V; Kalk KH; Goraj K; Martial JA; Hol WG
    Protein Sci; 1994 May; 3(5):810-21. PubMed ID: 8061610
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural considerations for the rational design of selective anti-trypanosomal agents: the role of the aromatic clusters at the interface of triosephosphate isomerase dimer.
    Espinoza-Fonseca LM; Trujillo-Ferrara JG
    Biochem Biophys Res Commun; 2005 Mar; 328(4):922-8. PubMed ID: 15707966
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structures of substrates and products bound to the phosphoglycerate kinase active site reveal the catalytic mechanism.
    Bernstein BE; Hol WG
    Biochemistry; 1998 Mar; 37(13):4429-36. PubMed ID: 9521762
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Derivatization of the interface cysteine of triosephosphate isomerase from Trypanosoma brucei and Trypanosoma cruzi as probe of the interrelationship between the catalytic sites and the dimer interface.
    Pérez-Montfort R; Garza-Ramos G; Alcántara GH; Reyes-Vivas H; Gao XG; Maldonado E; de Gómez-Puyou MT; Gómez-Puyou A
    Biochemistry; 1999 Mar; 38(13):4114-20. PubMed ID: 10194326
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The transition between the open and closed states of rubisco is triggered by the inter-phosphate distance of the bound bisphosphate.
    Duff AP; Andrews TJ; Curmi PM
    J Mol Biol; 2000 May; 298(5):903-16. PubMed ID: 10801357
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM.
    Alahuhta M; Casteleijn MG; Neubauer P; Wierenga RK
    Acta Crystallogr D Biol Crystallogr; 2008 Feb; 64(Pt 2):178-88. PubMed ID: 18219118
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Active site properties of monomeric triosephosphate isomerase (monoTIM) as deduced from mutational and structural studies.
    Schliebs W; Thanki N; Eritja R; Wierenga R
    Protein Sci; 1996 Feb; 5(2):229-39. PubMed ID: 8745400
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structures of Plasmodium falciparum triosephosphate isomerase complexed to substrate analogues: observation of the catalytic loop in the open conformation in the ligand-bound state.
    Parthasarathy S; Balaram H; Balaram P; Murthy MR
    Acta Crystallogr D Biol Crystallogr; 2002 Dec; 58(Pt 12):1992-2000. PubMed ID: 12454456
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Comparison of the refined crystal structures of liganded and unliganded chicken, yeast and trypanosomal triosephosphate isomerase.
    Wierenga RK; Noble ME; Davenport RC
    J Mol Biol; 1992 Apr; 224(4):1115-26. PubMed ID: 1569570
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.