244 related articles for article (PubMed ID: 20630764)
1. N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.
Huhtiniemi T; Suuronen T; Lahtela-Kakkonen M; Bruijn T; Jääskeläinen S; Poso A; Salminen A; Leppänen J; Jarho E
Bioorg Med Chem; 2010 Aug; 18(15):5616-25. PubMed ID: 20630764
[TBL] [Abstract][Full Text] [Related]
2. Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.
Smith BC; Denu JM
Biochemistry; 2007 Dec; 46(50):14478-86. PubMed ID: 18027980
[TBL] [Abstract][Full Text] [Related]
3. N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
Kiviranta PH; Suuronen T; Wallén EA; Leppänen J; Tervonen J; Kyrylenko S; Salminen A; Poso A; Jarho EM
J Med Chem; 2009 Apr; 52(7):2153-6. PubMed ID: 19296597
[TBL] [Abstract][Full Text] [Related]
4. Sirtuin mechanism and inhibition: explored with N(ε)-acetyl-lysine analogs.
Hirsch BM; Zheng W
Mol Biosyst; 2011 Jan; 7(1):16-28. PubMed ID: 20842312
[TBL] [Abstract][Full Text] [Related]
5. N(epsilon)-methanesulfonyl-lysine as a non-hydrolyzable functional surrogate for N(epsilon)-acetyl-lysine.
Jamonnak N; Fatkins DG; Wei L; Zheng W
Org Biomol Chem; 2007 Mar; 5(6):892-6. PubMed ID: 17340003
[TBL] [Abstract][Full Text] [Related]
6. Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs.
Jamonnak N; Hirsch BM; Pang Y; Zheng W
Bioorg Chem; 2010 Feb; 38(1):17-25. PubMed ID: 19914676
[TBL] [Abstract][Full Text] [Related]
7. Cyclic peptide-based potent and selective SIRT1/2 dual inhibitors harboring N
Chen D; Zheng W
Bioorg Med Chem Lett; 2016 Nov; 26(21):5234-5239. PubMed ID: 27707605
[TBL] [Abstract][Full Text] [Related]
8. Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2.
Galli U; Mesenzani O; Coppo C; Sorba G; Canonico PL; Tron GC; Genazzani AA
Eur J Med Chem; 2012 Sep; 55():58-66. PubMed ID: 22835719
[TBL] [Abstract][Full Text] [Related]
9. Capillary electrophoresis-based sirtuin assay using non-peptide substrates.
Fan Y; Hense M; Ludewig R; Weisgerber C; Scriba GK
J Pharm Biomed Anal; 2011 Mar; 54(4):772-8. PubMed ID: 21074959
[TBL] [Abstract][Full Text] [Related]
10. Recent advances in inhibitors of sirtuin1/2: an update and perspective.
Zhou Z; Ma T; Zhu Q; Xu Y; Zha X
Future Med Chem; 2018 Apr; 10(8):907-934. PubMed ID: 29642711
[TBL] [Abstract][Full Text] [Related]
11. Bivalent SIRT1 inhibitors.
Wang J; Zang W; Liu J; Zheng W
Bioorg Med Chem Lett; 2017 Jan; 27(2):180-186. PubMed ID: 27964881
[TBL] [Abstract][Full Text] [Related]
12. Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.
Borra MT; Langer MR; Slama JT; Denu JM
Biochemistry; 2004 Aug; 43(30):9877-87. PubMed ID: 15274642
[TBL] [Abstract][Full Text] [Related]
13. Hit-to-lead optimization on aryloxybenzamide derivative virtual screening hit against SIRT.
Yagci S; Gozelle M; Kaya SG; Ozkan Y; Aksel AB; Bakar-Ates F; Dundar Y; Eren G
Bioorg Med Chem; 2021 Jan; 30():115961. PubMed ID: 33360574
[TBL] [Abstract][Full Text] [Related]
14. Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton.
Sakai T; Matsumoto Y; Ishikawa M; Sugita K; Hashimoto Y; Wakai N; Kitao A; Morishita E; Toyoshima C; Hayashi T; Akiyama T
Bioorg Med Chem; 2015 Jan; 23(2):328-39. PubMed ID: 25515955
[TBL] [Abstract][Full Text] [Related]
15. Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2.
Manjula R; Gokhale N; Unni S; Deshmukh P; Reddyrajula R; Srinivas Bharath MM; Dalimba U; Padmanabhan B
Bioorg Chem; 2019 Nov; 92():103281. PubMed ID: 31561106
[TBL] [Abstract][Full Text] [Related]
16. Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies.
Mellini P; Carafa V; Di Rienzo B; Rotili D; De Vita D; Cirilli R; Gallinella B; Provvisiero DP; Di Maro S; Novellino E; Altucci L; Mai A
ChemMedChem; 2012 Nov; 7(11):1905-8. PubMed ID: 24155041
[TBL] [Abstract][Full Text] [Related]
17. Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases.
Smith BC; Denu JM
J Biol Chem; 2007 Dec; 282(51):37256-65. PubMed ID: 17951578
[TBL] [Abstract][Full Text] [Related]
18. Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2.
Huhtiniemi T; Salo HS; Suuronen T; Poso A; Salminen A; Leppänen J; Jarho E; Lahtela-Kakkonen M
J Med Chem; 2011 Oct; 54(19):6456-68. PubMed ID: 21895016
[TBL] [Abstract][Full Text] [Related]
19. Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins.
Botta G; De Santis LP; Saladino R
Curr Med Chem; 2012; 19(34):5871-84. PubMed ID: 22998567
[TBL] [Abstract][Full Text] [Related]
20. Nepsilon-thioacetyl-lysine: a multi-facet functional probe for enzymatic protein lysine Nepsilon-deacetylation.
Fatkins DG; Monnot AD; Zheng W
Bioorg Med Chem Lett; 2006 Jul; 16(14):3651-6. PubMed ID: 16697640
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
