127 related articles for article (PubMed ID: 20634071)
1. Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.
Gleave RJ; Walter DS; Beswick PJ; Fonfria E; Michel AD; Roman SA; Tang SP
Bioorg Med Chem Lett; 2010 Aug; 20(16):4951-4. PubMed ID: 20634071
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.
Chambers LJ; Stevens AJ; Moses AP; Michel AD; Walter DS; Davies DJ; Livermore DG; Fonfria E; Demont EH; Vimal M; Theobald PJ; Beswick PJ; Gleave RJ; Roman SA; Senger S
Bioorg Med Chem Lett; 2010 May; 20(10):3161-4. PubMed ID: 20399651
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Merriman GH; Ma L; Shum P; McGarry D; Volz F; Sabol JS; Gross A; Zhao Z; Rampe D; Wang L; Wirtz-Brugger F; Harris BA; Macdonald D
Bioorg Med Chem Lett; 2005 Jan; 15(2):435-8. PubMed ID: 15603968
[TBL] [Abstract][Full Text] [Related]
4. Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist.
Brotherton-Pleiss CE; Dillon MP; Ford AP; Gever JR; Carter DS; Gleason SK; Lin CJ; Moore AG; Thompson AW; Villa M; Zhai Y
Bioorg Med Chem Lett; 2010 Feb; 20(3):1031-6. PubMed ID: 20045645
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists.
Florjancic AS; Peddi S; Perez-Medrano A; Li B; Namovic MT; Grayson G; Donnelly-Roberts DL; Jarvis MF; Carroll WA
Bioorg Med Chem Lett; 2008 Mar; 18(6):2089-92. PubMed ID: 18272366
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists.
Morytko MJ; Betschmann P; Woller K; Ericsson A; Chen H; Donnelly-Roberts DL; Namovic MT; Jarvis MF; Carroll WA; Rafferty P
Bioorg Med Chem Lett; 2008 Mar; 18(6):2093-6. PubMed ID: 18272365
[TBL] [Abstract][Full Text] [Related]
7. Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist.
Kassack MU; Braun K; Ganso M; Ullmann H; Nickel P; Böing B; Müller G; Lambrecht G
Eur J Med Chem; 2004 Apr; 39(4):345-57. PubMed ID: 15072843
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
Almansa C; Alfón J; de Arriba AF; Cavalcanti FL; Escamilla I; Gómez LA; Miralles A; Soliva R; Bartrolí J; Carceller E; Merlos M; García-Rafanell J
J Med Chem; 2003 Jul; 46(16):3463-75. PubMed ID: 12877584
[TBL] [Abstract][Full Text] [Related]
9. Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.
Navidpour L; Shadnia H; Shafaroodi H; Amini M; Dehpour AR; Shafiee A
Bioorg Med Chem; 2007 Mar; 15(5):1976-82. PubMed ID: 17258905
[TBL] [Abstract][Full Text] [Related]
10. Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists.
Carroll WA; Kalvin DM; Perez Medrano A; Florjancic AS; Wang Y; Donnelly-Roberts DL; Namovic MT; Grayson G; Honoré P; Jarvis MF
Bioorg Med Chem Lett; 2007 Jul; 17(14):4044-8. PubMed ID: 17482819
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists.
Lee JY; Yu J; Cho WJ; Ko H; Kim YC
Bioorg Med Chem Lett; 2009 Nov; 19(21):6053-8. PubMed ID: 19800793
[TBL] [Abstract][Full Text] [Related]
12. Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.
Betschmann P; Bettencourt B; Donnelly-Roberts D; Friedman M; George J; Hirst G; Josephsohn N; Konopacki D; Li B; Maull J; Morytko MJ; Moore NS; Namovic M; Rafferty P; Salmeron-Garcia JA; Tarcsa E; Wang L; Woller K
Bioorg Med Chem Lett; 2008 Jul; 18(14):3848-51. PubMed ID: 18595695
[TBL] [Abstract][Full Text] [Related]
13. Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.
Laufer SA; Wagner GK; Kotschenreuther DA; Albrecht W
J Med Chem; 2003 Jul; 46(15):3230-44. PubMed ID: 12852754
[TBL] [Abstract][Full Text] [Related]
14. Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.
Beswick PJ; Billinton A; Chambers LJ; Dean DK; Fonfria E; Gleave RJ; Medhurst SJ; Michel AD; Moses AP; Patel S; Roman SA; Roomans S; Senger S; Stevens AJ; Walter DS
Bioorg Med Chem Lett; 2010 Aug; 20(15):4653-6. PubMed ID: 20579878
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity.
Chandra T; Garg N; Lata S; Saxena KK; Kumar A
Eur J Med Chem; 2010 May; 45(5):1772-6. PubMed ID: 20149499
[TBL] [Abstract][Full Text] [Related]
16. Tricyclic imidazole antagonists of the Neuropeptide S Receptor.
Trotter BW; Nanda KK; Manley PJ; Uebele VN; Condra CL; Gotter AL; Menzel K; Henault M; Stocco R; Renger JJ; Hartman GD; Bilodeau MT
Bioorg Med Chem Lett; 2010 Aug; 20(15):4704-8. PubMed ID: 20615693
[TBL] [Abstract][Full Text] [Related]
17. Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism.
Terasaka T; Tsuji K; Kato T; Nakanishi I; Kinoshita T; Kato Y; Kuno M; Inoue T; Tanaka K; Nakamura K
J Med Chem; 2005 Jul; 48(15):4750-3. PubMed ID: 16033254
[TBL] [Abstract][Full Text] [Related]
18. Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Abdi MH; Beswick PJ; Billinton A; Chambers LJ; Charlton A; Collins SD; Collis KL; Dean DK; Fonfria E; Gleave RJ; Lejeune CL; Livermore DG; Medhurst SJ; Michel AD; Moses AP; Page L; Patel S; Roman SA; Senger S; Slingsby B; Steadman JG; Stevens AJ; Walter DS
Bioorg Med Chem Lett; 2010 Sep; 20(17):5080-4. PubMed ID: 20673717
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents.
Amir M; Kumar H; Khan SA
Bioorg Med Chem Lett; 2008 Feb; 18(3):918-22. PubMed ID: 18182288
[TBL] [Abstract][Full Text] [Related]
20. Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation.
Broom DC; Matson DJ; Bradshaw E; Buck ME; Meade R; Coombs S; Matchett M; Ford KK; Yu W; Yuan J; Sun SH; Ochoa R; Krause JE; Wustrow DJ; Cortright DN
J Pharmacol Exp Ther; 2008 Dec; 327(3):620-33. PubMed ID: 18772321
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
