143 related articles for article (PubMed ID: 20645061)
1. The use of hepatocytes to investigate drug uptake transporters.
Maeda K; Sugiyama Y
Methods Mol Biol; 2010; 640():327-53. PubMed ID: 20645061
[TBL] [Abstract][Full Text] [Related]
2. The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.
Lundquist P; Lööf J; Sohlenius-Sternbeck AK; Floby E; Johansson J; Bylund J; Hoogstraate J; Afzelius L; Andersson TB
Drug Metab Dispos; 2014 Mar; 42(3):469-80. PubMed ID: 24396146
[TBL] [Abstract][Full Text] [Related]
3. Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.
De Bruyn T; Ye ZW; Peeters A; Sahi J; Baes M; Augustijns PF; Annaert PP
Eur J Pharm Sci; 2011 Jul; 43(4):297-307. PubMed ID: 21605667
[TBL] [Abstract][Full Text] [Related]
4. Characterization of digoxin uptake in sandwich-cultured human hepatocytes.
Kimoto E; Chupka J; Xiao Y; Bi YA; Duignan DB
Drug Metab Dispos; 2011 Jan; 39(1):47-53. PubMed ID: 20926619
[TBL] [Abstract][Full Text] [Related]
5. Hepatic uptake in the dog: comparison of uptake in hepatocytes and human embryonic kidney cells expressing dog organic anion-transporting polypeptide 1B4.
Wilby AJ; Maeda K; Courtney PF; Debori Y; Webborn PJ; Kitamura Y; Kusuhara H; Riley RJ; Sugiyama Y
Drug Metab Dispos; 2011 Dec; 39(12):2361-9. PubMed ID: 21940906
[TBL] [Abstract][Full Text] [Related]
6. Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
Bosgra S; van de Steeg E; Vlaming ML; Verhoeckx KC; Huisman MT; Verwei M; Wortelboer HM
Eur J Pharm Sci; 2014 Dec; 65():156-66. PubMed ID: 25261337
[TBL] [Abstract][Full Text] [Related]
7. Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.
Soars MG; Grime K; Sproston JL; Webborn PJ; Riley RJ
Drug Metab Dispos; 2007 Jun; 35(6):859-65. PubMed ID: 17344337
[TBL] [Abstract][Full Text] [Related]
8. Uptake and efflux transporters for conjugates in human hepatocytes.
Keppler D
Methods Enzymol; 2005; 400():531-42. PubMed ID: 16399368
[TBL] [Abstract][Full Text] [Related]
9. Evaluation of transporter-mediated hepatic uptake in a non-radioactive high-throughput assay: a study of kinetics, species difference and plasma protein effect.
Li L; Nouraldeen A; Wilson AG
Xenobiotica; 2013 Mar; 43(3):253-62. PubMed ID: 22928802
[TBL] [Abstract][Full Text] [Related]
10. Transporters as a determinant of drug clearance and tissue distribution.
Shitara Y; Horie T; Sugiyama Y
Eur J Pharm Sci; 2006 Apr; 27(5):425-46. PubMed ID: 16488580
[TBL] [Abstract][Full Text] [Related]
11. Prediction of the overall renal tubular secretion and hepatic clearance of anionic drugs and a renal drug-drug interaction involving organic anion transporter 3 in humans by in vitro uptake experiments.
Watanabe T; Kusuhara H; Watanabe T; Debori Y; Maeda K; Kondo T; Nakayama H; Horita S; Ogilvie BW; Parkinson A; Hu Z; Sugiyama Y
Drug Metab Dispos; 2011 Jun; 39(6):1031-8. PubMed ID: 21383204
[TBL] [Abstract][Full Text] [Related]
12. Long-lasting inhibition of the transporter-mediated hepatic uptake of sulfobromophthalein by cyclosporin a in rats.
Shitara Y; Nagamatsu Y; Wada S; Sugiyama Y; Horie T
Drug Metab Dispos; 2009 Jun; 37(6):1172-8. PubMed ID: 19282398
[TBL] [Abstract][Full Text] [Related]
13. Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
Jones HM; Barton HA; Lai Y; Bi YA; Kimoto E; Kempshall S; Tate SC; El-Kattan A; Houston JB; Galetin A; Fenner KS
Drug Metab Dispos; 2012 May; 40(5):1007-17. PubMed ID: 22344703
[TBL] [Abstract][Full Text] [Related]
14. Prediction of the hepatic and renal clearance of transporter substrates in rats using in vitro uptake experiments.
Watanabe T; Maeda K; Kondo T; Nakayama H; Horita S; Kusuhara H; Sugiyama Y
Drug Metab Dispos; 2009 Jul; 37(7):1471-9. PubMed ID: 19364828
[TBL] [Abstract][Full Text] [Related]
15. Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent.
Takeuchi K; Sugiura T; Umeda S; Matsubara K; Horikawa M; Nakamichi N; Silver DL; Ishiwata N; Kato Y
Drug Metab Dispos; 2011 Jun; 39(6):1088-96. PubMed ID: 21422191
[TBL] [Abstract][Full Text] [Related]
16. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.
Ho RH; Tirona RG; Leake BF; Glaeser H; Lee W; Lemke CJ; Wang Y; Kim RB
Gastroenterology; 2006 May; 130(6):1793-806. PubMed ID: 16697742
[TBL] [Abstract][Full Text] [Related]
17. Culture period-dependent changes in the uptake of transporter substrates in sandwich-cultured rat and human hepatocytes.
Kotani N; Maeda K; Watanabe T; Hiramatsu M; Gong LK; Bi YA; Takezawa T; Kusuhara H; Sugiyama Y
Drug Metab Dispos; 2011 Sep; 39(9):1503-10. PubMed ID: 21673128
[TBL] [Abstract][Full Text] [Related]
18. Pitavastatin as an in vivo probe for studying hepatic organic anion transporting polypeptide-mediated drug-drug interactions in cynomolgus monkeys.
Takahashi T; Ohtsuka T; Yoshikawa T; Tatekawa I; Uno Y; Utoh M; Yamazaki H; Kume T
Drug Metab Dispos; 2013 Oct; 41(10):1875-82. PubMed ID: 23929936
[TBL] [Abstract][Full Text] [Related]
19. Investigation of the rate-determining process in the hepatic elimination of HMG-CoA reductase inhibitors in rats and humans.
Watanabe T; Kusuhara H; Maeda K; Kanamaru H; Saito Y; Hu Z; Sugiyama Y
Drug Metab Dispos; 2010 Feb; 38(2):215-22. PubMed ID: 19875501
[TBL] [Abstract][Full Text] [Related]
20. The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.
Fenner KS; Jones HM; Ullah M; Kempshall S; Dickins M; Lai Y; Morgan P; Barton HA
Xenobiotica; 2012 Jan; 42(1):28-45. PubMed ID: 22077101
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]