81 related articles for article (PubMed ID: 20650635)
1. Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.
Kurosumi M; Nishio Y; Osawa S; Kobayashi H; Iwatsubo T; Tomita T; Miyachi H
Bioorg Med Chem Lett; 2010 Sep; 20(17):5282-5. PubMed ID: 20650635
[TBL] [Abstract][Full Text] [Related]
2. Discovery of a novel series of Notch-sparing gamma-secretase inhibitors.
Kreft A; Harrison B; Aschmies S; Atchison K; Casebier D; Cole DC; Diamantidis G; Ellingboe J; Hauze D; Hu Y; Huryn D; Jin M; Kubrak D; Lu P; Lundquist J; Mann C; Martone R; Moore W; Oganesian A; Porte A; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Woller K; Xu Z; Zhou H; Steven Jacobsen J
Bioorg Med Chem Lett; 2008 Jul; 18(14):4232-6. PubMed ID: 18556202
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.
Hieke M; Ness J; Steri R; Dittrich M; Greiner C; Werz O; Baumann K; Schubert-Zsilavecz M; Weggen S; Zettl H
J Med Chem; 2010 Jun; 53(12):4691-700. PubMed ID: 20503989
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
[TBL] [Abstract][Full Text] [Related]
5. Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
Liao YF; Wang BJ; Hsu WM; Lee H; Liao CY; Wu SY; Cheng HT; Hu MK
Mol Pharmacol; 2007 Feb; 71(2):588-601. PubMed ID: 17105873
[TBL] [Abstract][Full Text] [Related]
6. [Inhibitors for Notch and gamma-secretase. Biology of T-cell leukemia].
Yahagi Y; Usui N
Gan To Kagaku Ryoho; 2009 May; 36(5):744-8. PubMed ID: 19496283
[No Abstract] [Full Text] [Related]
7. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
[TBL] [Abstract][Full Text] [Related]
8. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
Kaether C; Schmitt S; Willem M; Haass C
Traffic; 2006 Apr; 7(4):408-15. PubMed ID: 16536739
[TBL] [Abstract][Full Text] [Related]
9. Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.
Kasuga J; Oyama T; Hirakawa Y; Makishima M; Morikawa K; Hashimoto Y; Miyachi H
Bioorg Med Chem Lett; 2008 Aug; 18(16):4525-8. PubMed ID: 18662876
[TBL] [Abstract][Full Text] [Related]
10. [Biology and pathobiology of the intramembrane proteolysis by gamma-secretase].
Tomita T
Tanpakushitsu Kakusan Koso; 2009 Oct; 54(13):1747-53. PubMed ID: 19827607
[No Abstract] [Full Text] [Related]
11. Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes.
Tasaka T; Akiyoshi T; Yamaguchi K; Tanaka M; Onishi H; Katano M
Anticancer Res; 2010 Dec; 30(12):4999-5010. PubMed ID: 21187481
[TBL] [Abstract][Full Text] [Related]
12. Structural optimization of a CXCR2-directed antagonist that indirectly inhibits gamma-secretase and reduces Abeta.
Bakshi P; Jin C; Broutin P; Berhane B; Reed J; Mullan M
Bioorg Med Chem; 2009 Dec; 17(23):8102-12. PubMed ID: 19853461
[TBL] [Abstract][Full Text] [Related]
13. Alpha-alkyl substituted pirinixic acid derivatives as potent dual agonists of the peroxisome proliferator activated receptor alpha and gamma.
Rau O; Syha Y; Zettl H; Kock M; Bock A; Schubert-Zsilavecz M
Arch Pharm (Weinheim); 2008 Mar; 341(3):191-5. PubMed ID: 18275039
[TBL] [Abstract][Full Text] [Related]
14. Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.
Xu R; Cole D; Asberom T; Bara T; Bennett C; Burnett DA; Clader J; Domalski M; Greenlee W; Hyde L; Josien H; Li H; McBriar M; McKittrick B; McPhail AT; Pissarnitski D; Qiang L; Rajagopalan M; Sasikumar T; Su J; Tang H; Wu WL; Zhang L; Zhao Z
Bioorg Med Chem Lett; 2010 Apr; 20(8):2591-6. PubMed ID: 20236824
[TBL] [Abstract][Full Text] [Related]
15. Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.
Mayer SC; Kreft AF; Harrison B; Abou-Gharbia M; Antane M; Aschmies S; Atchison K; Chlenov M; Cole DC; Comery T; Diamantidis G; Ellingboe J; Fan K; Galante R; Gonzales C; Ho DM; Hoke ME; Hu Y; Huryn D; Jain U; Jin M; Kremer K; Kubrak D; Lin M; Lu P; Magolda R; Martone R; Moore W; Oganesian A; Pangalos MN; Porte A; Reinhart P; Resnick L; Riddell DR; Sonnenberg-Reines J; Stock JR; Sun SC; Wagner E; Wang T; Woller K; Xu Z; Zaleska MM; Zeldis J; Zhang M; Zhou H; Jacobsen JS
J Med Chem; 2008 Dec; 51(23):7348-51. PubMed ID: 19012391
[TBL] [Abstract][Full Text] [Related]
16. APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.
Lefranc-Jullien S; Sunyach C; Checler F
J Neurochem; 2006 May; 97(3):807-17. PubMed ID: 16524370
[TBL] [Abstract][Full Text] [Related]
17. Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome.
Kasuga J; Yamasaki D; Araya Y; Nakagawa A; Makishima M; Doi T; Hashimoto Y; Miyachi H
Bioorg Med Chem; 2006 Dec; 14(24):8405-14. PubMed ID: 16996742
[TBL] [Abstract][Full Text] [Related]
18. SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.
Kasuga J; Yamasaki D; Ogura K; Shimizu M; Sato M; Makishima M; Doi T; Hashimoto Y; Miyachi H
Bioorg Med Chem Lett; 2008 Feb; 18(3):1110-5. PubMed ID: 18162399
[TBL] [Abstract][Full Text] [Related]
19. Three-dimensional quantitative structure-activity relationship modeling of gamma-secretase inhibitors using molecular field analysis.
Sammi T; Silakari O; Ravikumar M
Chem Biol Drug Des; 2008 Feb; 71(2):155-66. PubMed ID: 18221306
[TBL] [Abstract][Full Text] [Related]
20. Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor gamma (PPARgamma) agonists.
Ahn JH; Shin MS; Jung SH; Kim JA; Kim HM; Kim SH; Kang SK; Kim KR; Rhee SD; Park SD; Lee JM; Lee JH; Cheon HG; Kim SS
Bioorg Med Chem Lett; 2007 Sep; 17(18):5239-44. PubMed ID: 17624777
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
