113 related articles for article (PubMed ID: 20659685)
1. Discovery and characterization of the laulimalide-microtubule binding mode by mass shift perturbation mapping.
Bennett MJ; Barakat K; Huzil JT; Tuszynski J; Schriemer DC
Chem Biol; 2010 Jul; 17(7):725-34. PubMed ID: 20659685
[TBL] [Abstract][Full Text] [Related]
2. The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.
Churchill CD; Klobukowski M; Tuszynski JA
Chem Biol Drug Des; 2015 Aug; 86(2):190-9. PubMed ID: 25376845
[TBL] [Abstract][Full Text] [Related]
3. Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide-tubulin pharmacophore.
Churchill CD; Klobukowski M; Tuszynski JA
J Biomol Struct Dyn; 2016 Jul; 34(7):1455-69. PubMed ID: 26230757
[TBL] [Abstract][Full Text] [Related]
4. Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously.
Gapud EJ; Bai R; Ghosh AK; Hamel E
Mol Pharmacol; 2004 Jul; 66(1):113-21. PubMed ID: 15213302
[TBL] [Abstract][Full Text] [Related]
5. Structural basis of microtubule stabilization by laulimalide and peloruside A.
Prota AE; Bargsten K; Northcote PT; Marsh M; Altmann KH; Miller JH; Díaz JF; Steinmetz MO
Angew Chem Int Ed Engl; 2014 Feb; 53(6):1621-5. PubMed ID: 24470331
[TBL] [Abstract][Full Text] [Related]
6. Suppression of microtubule dynamics by binding of cemadotin to tubulin: possible mechanism for its antitumor action.
Jordan MA; Walker D; de Arruda M; Barlozzari T; Panda D
Biochemistry; 1998 Dec; 37(50):17571-8. PubMed ID: 9860873
[TBL] [Abstract][Full Text] [Related]
7. Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.
Clark EA; Hills PM; Davidson BS; Wender PA; Mooberry SL
Mol Pharm; 2006; 3(4):457-67. PubMed ID: 16889440
[TBL] [Abstract][Full Text] [Related]
8. βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug-tubulin interactions and microtubule stability.
Kanakkanthara A; Rowe MR; Field JJ; Northcote PT; Teesdale-Spittle PH; Miller JH
Cancer Lett; 2015 Sep; 365(2):251-60. PubMed ID: 26052091
[TBL] [Abstract][Full Text] [Related]
9. Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.
Zúñiga MA; Alderete JB; Jaña GA; Jiménez VA
J Comput Aided Mol Des; 2017 Jul; 31(7):643-652. PubMed ID: 28597356
[TBL] [Abstract][Full Text] [Related]
10. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents.
Mooberry SL; Tien G; Hernandez AH; Plubrukarn A; Davidson BS
Cancer Res; 1999 Feb; 59(3):653-60. PubMed ID: 9973214
[TBL] [Abstract][Full Text] [Related]
11. Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
Khrapunovich-Baine M; Menon V; Yang CP; Northcote PT; Miller JH; Angeletti RH; Fiser A; Horwitz SB; Xiao H
J Biol Chem; 2011 Apr; 286(13):11765-78. PubMed ID: 21245138
[TBL] [Abstract][Full Text] [Related]
12. In vitro and in vivo anticancer activities of synthetic (-)-laulimalide, a marine natural product microtubule stabilizing agent.
Liu J; Towle MJ; Cheng H; Saxton P; Reardon C; Wu J; Murphy EA; Kuznetsov G; Johannes CW; Tremblay MR; Zhao H; Pesant M; Fang FG; Vermeulen MW; Gallagher BM; Littlefield BA
Anticancer Res; 2007; 27(3B):1509-18. PubMed ID: 17595769
[TBL] [Abstract][Full Text] [Related]
13. A unique mode of microtubule stabilization induced by peloruside A.
Huzil JT; Chik JK; Slysz GW; Freedman H; Tuszynski J; Taylor RE; Sackett DL; Schriemer DC
J Mol Biol; 2008 May; 378(5):1016-30. PubMed ID: 18405918
[TBL] [Abstract][Full Text] [Related]
14. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site.
Edler MC; Buey RM; Gussio R; Marcus AI; Vanderwal CD; Sorensen EJ; Díaz JF; Giannakakou P; Hamel E
Biochemistry; 2005 Aug; 44(34):11525-38. PubMed ID: 16114889
[TBL] [Abstract][Full Text] [Related]
15. Localization of the antimitotic peptide and depsipeptide binding site on beta-tubulin.
Mitra A; Sept D
Biochemistry; 2004 Nov; 43(44):13955-62. PubMed ID: 15518544
[TBL] [Abstract][Full Text] [Related]
16. Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity.
Buey RM; Díaz JF; Andreu JM; O'Brate A; Giannakakou P; Nicolaou KC; Sasmal PK; Ritzén A; Namoto K
Chem Biol; 2004 Feb; 11(2):225-36. PubMed ID: 15123284
[TBL] [Abstract][Full Text] [Related]
17. Microtubule interactions with chemically diverse stabilizing agents: thermodynamics of binding to the paclitaxel site predicts cytotoxicity.
Buey RM; Barasoain I; Jackson E; Meyer A; Giannakakou P; Paterson I; Mooberry S; Andreu JM; Díaz JF
Chem Biol; 2005 Dec; 12(12):1269-79. PubMed ID: 16356844
[TBL] [Abstract][Full Text] [Related]
18. Synthetic approaches to the microtubule stabilizing agent (-)-laulimalide.
Crimmins MT
Curr Opin Drug Discov Devel; 2002 Nov; 5(6):944-59. PubMed ID: 12478725
[TBL] [Abstract][Full Text] [Related]
19. The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.
Pryor DE; O'Brate A; Bilcer G; Díaz JF; Wang Y; Wang Y; Kabaki M; Jung MK; Andreu JM; Ghosh AK; Giannakakou P; Hamel E
Biochemistry; 2002 Jul; 41(29):9109-15. PubMed ID: 12119025
[TBL] [Abstract][Full Text] [Related]
20. Wangzaozin A, a potent novel microtubule stabilizer, targets both the taxane and laulimalide sites on β-tubulin through molecular dynamics simulations.
Yang MH; Mao J; Zhu JH; Zhang H; Ding L
Life Sci; 2022 Jul; 301():120583. PubMed ID: 35504334
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
