BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 20664530)

  • 1. α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.
    Gorbatyuk OS; Li S; Nguyen FN; Manfredsson FP; Kondrikova G; Sullivan LF; Meyers C; Chen W; Mandel RJ; Muzyczka N
    Mol Ther; 2010 Oct; 18(10):1758-68. PubMed ID: 20664530
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.
    Mendez-Gomez HR; Singh J; Meyers C; Chen W; Gorbatyuk OS; Muzyczka N
    Neuroscience; 2018 May; 377():174-183. PubMed ID: 29526688
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration.
    Gorbatyuk OS; Li S; Nash K; Gorbatyuk M; Lewin AS; Sullivan LF; Mandel RJ; Chen W; Meyers C; Manfredsson FP; Muzyczka N
    Mol Ther; 2010 Aug; 18(8):1450-7. PubMed ID: 20551914
    [TBL] [Abstract][Full Text] [Related]  

  • 4. rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.
    Oliveras-Salvá M; Van der Perren A; Casadei N; Stroobants S; Nuber S; D'Hooge R; Van den Haute C; Baekelandt V
    Mol Neurodegener; 2013 Nov; 8():44. PubMed ID: 24267638
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression.
    Maingay M; Romero-Ramos M; Carta M; Kirik D
    Neurobiol Dis; 2006 Sep; 23(3):522-32. PubMed ID: 16806952
    [TBL] [Abstract][Full Text] [Related]  

  • 6. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease.
    Ip CW; Klaus LC; Karikari AA; Visanji NP; Brotchie JM; Lang AE; Volkmann J; Koprich JB
    Acta Neuropathol Commun; 2017 Feb; 5(1):11. PubMed ID: 28143577
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.
    Klein RL; Dayton RD; Lin WL; Dickson DW
    Neurobiol Dis; 2005 Oct; 20(1):64-73. PubMed ID: 16137567
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.
    Paumier KL; Luk KC; Manfredsson FP; Kanaan NM; Lipton JW; Collier TJ; Steece-Collier K; Kemp CJ; Celano S; Schulz E; Sandoval IM; Fleming S; Dirr E; Polinski NK; Trojanowski JQ; Lee VM; Sortwell CE
    Neurobiol Dis; 2015 Oct; 82():185-199. PubMed ID: 26093169
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Allelic difference in Mhc2ta confers altered microglial activation and susceptibility to α-synuclein-induced dopaminergic neurodegeneration.
    Jimenez-Ferrer I; Jewett M; Tontanahal A; Romero-Ramos M; Swanberg M
    Neurobiol Dis; 2017 Oct; 106():279-290. PubMed ID: 28736195
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease.
    Faustini G; Longhena F; Varanita T; Bubacco L; Pizzi M; Missale C; Benfenati F; Björklund A; Spano P; Bellucci A
    Acta Neuropathol; 2018 Oct; 136(4):621-639. PubMed ID: 30046897
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.
    Fischer DL; Manfredsson FP; Kemp CJ; Cole-Strauss A; Lipton JW; Duffy MF; Polinski NK; Steece-Collier K; Collier TJ; Gombash SE; Buhlinger DJ; Sortwell CE
    Sci Rep; 2017 Nov; 7(1):16356. PubMed ID: 29180681
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Progressive neurodegeneration or endogenous compensation in an animal model of Parkinson's disease produced by decreasing doses of alpha-synuclein.
    Koprich JB; Johnston TH; Huot P; Reyes MG; Espinosa M; Brotchie JM
    PLoS One; 2011 Mar; 6(3):e17698. PubMed ID: 21408191
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.
    Buck K; Landeck N; Ulusoy A; Majbour NK; El-Agnaf OM; Kirik D
    Neurobiol Dis; 2015 Jun; 78():100-14. PubMed ID: 25818009
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.
    Gorbatyuk MS; Shabashvili A; Chen W; Meyers C; Sullivan LF; Salganik M; Lin JH; Lewin AS; Muzyczka N; Gorbatyuk OS
    Mol Ther; 2012 Jul; 20(7):1327-37. PubMed ID: 22434142
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Alpha-synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: lessons from viral transduction of knockout mice.
    Alerte TN; Akinfolarin AA; Friedrich EE; Mader SA; Hong CS; Perez RG
    Neurosci Lett; 2008 Apr; 435(1):24-9. PubMed ID: 18314273
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system.
    Gombash SE; Manfredsson FP; Kemp CJ; Kuhn NC; Fleming SM; Egan AE; Grant LM; Ciucci MR; MacKeigan JP; Sortwell CE
    PLoS One; 2013; 8(11):e81426. PubMed ID: 24312298
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in Mouse.
    Song LK; Ma KL; Yuan YH; Mu Z; Song XY; Niu F; Han N; Chen NH
    PLoS One; 2015; 10(6):e0131281. PubMed ID: 26114655
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.
    Park SS; Schulz EM; Lee D
    Eur J Neurosci; 2007 Dec; 26(11):3104-12. PubMed ID: 18005066
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.
    Lu XH; Fleming SM; Meurers B; Ackerson LC; Mortazavi F; Lo V; Hernandez D; Sulzer D; Jackson GR; Maidment NT; Chesselet MF; Yang XW
    J Neurosci; 2009 Feb; 29(7):1962-76. PubMed ID: 19228951
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice.
    Pavia-Collado R; Rodríguez-Aller R; Alarcón-Arís D; Miquel-Rio L; Ruiz-Bronchal E; Paz V; Campa L; Galofré M; Sgambato V; Bortolozzi A
    Int J Mol Sci; 2022 Feb; 23(3):. PubMed ID: 35163729
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.