These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 20667732)

  • 21. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.
    Williams R; Niswender CM; Luo Q; Le U; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2009 Feb; 19(3):962-6. PubMed ID: 19097893
    [TBL] [Abstract][Full Text] [Related]  

  • 22. SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide.
    Barda DA; Wang ZQ; Britton TC; Henry SS; Jagdmann GE; Coleman DS; Johnson MP; Andis SL; Schoepp DD
    Bioorg Med Chem Lett; 2004 Jun; 14(12):3099-102. PubMed ID: 15149652
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine.
    Johnson MP; Baez M; Jagdmann GE; Britton TC; Large TH; Callagaro DO; Tizzano JP; Monn JA; Schoepp DD
    J Med Chem; 2003 Jul; 46(15):3189-92. PubMed ID: 12852748
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1.
    Wen W; Wang Y; Li Z; Tseng PY; McManus OB; Wu M; Li M; Lindsley CW; Dong X; Hopkins CR
    ChemMedChem; 2015 Jan; 10(1):57-61. PubMed ID: 25209672
    [TBL] [Abstract][Full Text] [Related]  

  • 25. New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
    Trabanco AA; Duvey G; Cid JM; Macdonald GJ; Cluzeau P; Nhem V; Furnari R; Behaj N; Poulain G; Finn T; Lavreysen H; Poli S; Raux A; Thollon Y; Poirier N; D'Addona D; Andrés JI; Lutjens R; Le Poul E; Imogai H; Rocher JP
    Bioorg Med Chem Lett; 2011 Feb; 21(3):971-6. PubMed ID: 21232953
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.
    Hammond AS; Rodriguez AL; Townsend SD; Niswender CM; Gregory KJ; Lindsley CW; Conn PJ
    ACS Chem Neurosci; 2010 Oct; 1(10):702-716. PubMed ID: 20981342
    [TBL] [Abstract][Full Text] [Related]  

  • 27. mGlu
    Charvin D
    Neuropharmacology; 2018 Jun; 135():308-315. PubMed ID: 29578036
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Synthesis and SAR of a series of mGlu
    Kalbfleisch JJ; Reed CW; Park C; Spearing PK; Quitalig MC; Jenkins MT; Rodriguez AL; Blobaum AL; Conn PJ; Niswender CM; Lindsley CW
    Bioorg Med Chem Lett; 2020 Nov; 30(22):127529. PubMed ID: 32890686
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.
    Volpi C; Fallarino F; Mondanelli G; Macchiarulo A; Grohmann U
    Expert Opin Drug Discov; 2018 May; 13(5):411-423. PubMed ID: 29486616
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
    Varnes JG; Marcus AP; Mauger RC; Throner SR; Hoesch V; King MM; Wang X; Sygowski LA; Spear N; Gadient R; Brown DG; Campbell JB
    Bioorg Med Chem Lett; 2011 Mar; 21(5):1402-6. PubMed ID: 21295468
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Discovery and optimization of benzenesulfonanilide derivatives as a novel class of 11β-HSD1 inhibitors.
    Rew Y; DeGraffenreid M; He X; Jaen JC; McMinn DL; Sun D; Tu H; Ursu S; Powers JP
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3786-90. PubMed ID: 22542009
    [TBL] [Abstract][Full Text] [Related]  

  • 32. 3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
    Zhang L; Rogers BN; Duplantier AJ; McHardy SF; Efremov I; Berke H; Qian W; Zhang AQ; Maklad N; Candler J; Doran AC; Lazzaro JT; Ganong AH
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5493-6. PubMed ID: 18812259
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu
    Fulton MG; Loch MT; Rodriguez AL; Lin X; Javitch JA; Conn PJ; Niswender CM; Lindsley CW
    Bioorg Med Chem Lett; 2020 Jul; 30(13):127212. PubMed ID: 32371100
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.
    Gogliotti RD; Engers DW; Garcia-Barrantes PM; Panarese JD; Gentry PR; Blobaum AL; Morrison RD; Daniels JS; Thompson AD; Jones CK; Conn PJ; Niswender CM; Lindsley CW; Hopkins CR
    Bioorg Med Chem Lett; 2016 Jun; 26(12):2915-2919. PubMed ID: 27131990
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.
    Butkiewicz M; Rodriguez AL; Rainey SE; Wieting J; Luscombe VB; Stauffer SR; Lindsley CW; Conn PJ; Meiler J
    ACS Chem Neurosci; 2019 Aug; 10(8):3427-3436. PubMed ID: 31132237
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 1: SAR of modifications to the central aryl core.
    Garcia-Barrantes PM; Cho HP; Blobaum AL; Niswender CM; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2015 Nov; 25(22):5107-10. PubMed ID: 26476971
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Co-operative binding assay for the characterization of mGlu4 allosteric modulators.
    Poutiainen P; Kil KE; Zhang Z; Kuruppu D; Tannous B; Brownell AL
    Neuropharmacology; 2015 Oct; 97():142-8. PubMed ID: 26025660
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Discovery of 5-HT6 receptor ligands based on virtual HTS.
    Tasler S; Kraus J; Wuzik A; Müller O; Aschenbrenner A; Cubero E; Pascual R; Quintana-Ruiz JR; Dordal A; Mercè R; Codony X
    Bioorg Med Chem Lett; 2007 Nov; 17(22):6224-9. PubMed ID: 17892934
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs).
    Szabó G; Kolok S; Orgován Z; Vastag M; Béni Z; Kóti J; Sághy K; Lévay GI; Greiner I; Keserű GM
    Eur J Med Chem; 2020 Jan; 186():111881. PubMed ID: 31780081
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5).
    Williams DL; Lindsley CW
    Curr Top Med Chem; 2005; 5(9):825-46. PubMed ID: 16178729
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.