BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 20673724)

  • 1. Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.
    Xue F; Huang J; Ji H; Fang J; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    Bioorg Med Chem; 2010 Sep; 18(17):6526-37. PubMed ID: 20673724
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase.
    Xue F; Kraus JM; Labby KJ; Ji H; Mataka J; Xia G; Li H; Delker SL; Roman LJ; Martásek P; Poulos TL; Silverman RB
    J Med Chem; 2011 Sep; 54(18):6399-403. PubMed ID: 21809851
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective monocationic inhibitors of neuronal nitric oxide synthase. Binding mode insights from molecular dynamics simulations.
    Huang H; Ji H; Li H; Jing Q; Labby KJ; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Am Chem Soc; 2012 Jul; 134(28):11559-72. PubMed ID: 22731813
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
    Xue F; Li H; Fang J; Roman LJ; Martásek P; Poulos TL; Silverman RB
    Bioorg Med Chem Lett; 2010 Nov; 20(21):6258-61. PubMed ID: 20833542
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
    Ji H; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2009 Feb; 52(3):779-97. PubMed ID: 19125620
    [TBL] [Abstract][Full Text] [Related]  

  • 6. In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
    Jing Q; Li H; Fang J; Roman LJ; Martásek P; Poulos TL; Silverman RB
    Bioorg Med Chem; 2013 Sep; 21(17):5323-31. PubMed ID: 23867386
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural basis for isoform-selective inhibition in nitric oxide synthase.
    Poulos TL; Li H
    Acc Chem Res; 2013 Feb; 46(2):390-8. PubMed ID: 23030042
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.
    Silverman RB
    Acc Chem Res; 2009 Mar; 42(3):439-51. PubMed ID: 19154146
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
    Igarashi J; Li H; Jamal J; Ji H; Fang J; Lawton GR; Silverman RB; Poulos TL
    J Med Chem; 2009 Apr; 52(7):2060-6. PubMed ID: 19296678
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
    Xue F; Fang J; Delker SL; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2011 Apr; 54(7):2039-48. PubMed ID: 21410186
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase .
    Delker SL; Xue F; Li H; Jamal J; Silverman RB; Poulos TL
    Biochemistry; 2010 Dec; 49(51):10803-10. PubMed ID: 21138269
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives.
    Ji H; Delker SL; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2010 Nov; 53(21):7804-24. PubMed ID: 20958055
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
    Seo J; Martásek P; Roman LJ; Silverman RB
    Bioorg Med Chem; 2007 Mar; 15(5):1928-38. PubMed ID: 17239601
    [TBL] [Abstract][Full Text] [Related]  

  • 14. First Contact: 7-Phenyl-2-Aminoquinolines, Potent and Selective Neuronal Nitric Oxide Synthase Inhibitors That Target an Isoform-Specific Aspartate.
    Cinelli MA; Reidl CT; Li H; Chreifi G; Poulos TL; Silverman RB
    J Med Chem; 2020 May; 63(9):4528-4554. PubMed ID: 32302123
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 2-Aminopyridines with a Truncated Side Chain To Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.
    Kang S; Li H; Tang W; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2015 Jul; 58(14):5548-60. PubMed ID: 26120733
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III).
    Carrión MD; López Cara LC; Camacho ME; Tapias V; Escames G; Acuña-Castroviejo D; Espinosa A; Gallo MA; Entrena A
    Eur J Med Chem; 2008 Nov; 43(11):2579-91. PubMed ID: 18325637
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of urea and thiourea kynurenamine derivatives: synthesis, molecular modeling, and biological evaluation as nitric oxide synthase inhibitors.
    Chayah M; Carrión MD; Gallo MA; Jiménez R; Duarte J; Camacho ME
    ChemMedChem; 2015 May; 10(5):874-82. PubMed ID: 25801086
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
    Huang H; Li H; Martásek P; Roman LJ; Poulos TL; Silverman RB
    J Med Chem; 2013 Apr; 56(7):3024-32. PubMed ID: 23451760
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC; Camacho ME; Carrión MD; Tapias V; Gallo MA; Escames G; Acuña-Castroviejo D; Espinosa A; Entrena A
    Eur J Med Chem; 2009 Jun; 44(6):2655-66. PubMed ID: 19117642
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Phenyl Ether- and Aniline-Containing 2-Aminoquinolines as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase.
    Cinelli MA; Li H; Pensa AV; Kang S; Roman LJ; Martásek P; Poulos TL; Silverman RB
    J Med Chem; 2015 Nov; 58(21):8694-712. PubMed ID: 26469213
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.