88 related articles for article (PubMed ID: 20674356)
21. Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.
Marminon C; Anizon F; Moreau P; Pfeiffer B; Pierré A; Golsteyn RM; Peixoto P; Hildebrand MP; David-Cordonnier MH; Lozach O; Meijer L; Prudhomme M
Mol Pharmacol; 2008 Dec; 74(6):1620-9. PubMed ID: 18768386
[TBL] [Abstract][Full Text] [Related]
22. 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.
Wang GT; Li G; Mantei RA; Chen Z; Kovar P; Gu W; Xiao Z; Zhang H; Sham HL; Sowin T; Rosenberg SH; Lin NH
J Med Chem; 2005 May; 48(9):3118-21. PubMed ID: 15857116
[TBL] [Abstract][Full Text] [Related]
23. Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.
Lefoix M; Coudert G; Routier S; Pfeiffer B; Caignard DH; Hickman J; Pierré A; Golsteyn RM; Léonce S; Bossard C; Mérour JY
Bioorg Med Chem; 2008 May; 16(9):5303-21. PubMed ID: 18342518
[TBL] [Abstract][Full Text] [Related]
24. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Smaill JB; Lee HH; Palmer BD; Thompson AM; Squire CJ; Baker EN; Booth RJ; Kraker A; Hook K; Denny WA
Bioorg Med Chem Lett; 2008 Feb; 18(3):929-33. PubMed ID: 18191399
[TBL] [Abstract][Full Text] [Related]
25. Identification of novel aminothiazole and aminothiadiazole conjugated cyanopyridines as selective CHK1 inhibitors.
Gomha SM; Abdulla MM; Abou-Seri SM
Eur J Med Chem; 2015 Mar; 92():459-70. PubMed ID: 25594740
[TBL] [Abstract][Full Text] [Related]
26. Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.
Hénon H; Messaoudi S; Anizon F; Aboab B; Kucharczyk N; Léonce S; Golsteyn RM; Pfeiffer B; Prudhomme M
Eur J Pharmacol; 2007 Jan; 554(2-3):106-12. PubMed ID: 17134696
[TBL] [Abstract][Full Text] [Related]
27. Pyrrolocarbazoles as checkpoint 1 kinase inhibitors.
Hénon H; Conchon E; Hugon B; Messaoudi S; Golsteyn RM; Prudhomme M
Anticancer Agents Med Chem; 2008 Aug; 8(6):577-97. PubMed ID: 18690823
[TBL] [Abstract][Full Text] [Related]
28. Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase.
Garbaccio RM; Huang S; Tasber ES; Fraley ME; Yan Y; Munshi S; Ikuta M; Kuo L; Kreatsoulas C; Stirdivant S; Drakas B; Rickert K; Walsh ES; Hamilton KA; Buser CA; Hardwick J; Mao X; Beck SC; Abrams MT; Tao W; Lobell R; Sepp-Lorenzino L; Hartman GD
Bioorg Med Chem Lett; 2007 Nov; 17(22):6280-5. PubMed ID: 17900896
[TBL] [Abstract][Full Text] [Related]
29. Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.
Nishiguchi GA; Atallah G; Bellamacina C; Burger MT; Ding Y; Feucht PH; Garcia PD; Han W; Klivansky L; Lindvall M
Bioorg Med Chem Lett; 2011 Nov; 21(21):6366-9. PubMed ID: 21945284
[TBL] [Abstract][Full Text] [Related]
30. Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1',2':1,5]pyrazolo[3,4-d]pyrimidines.
Alberti MJ; Auten EP; Lackey KE; McDonald OB; Wood ER; Preugschat F; Cutler GJ; Kane-Carson L; Liu W; Jung DK
Bioorg Med Chem Lett; 2005 Aug; 15(16):3778-81. PubMed ID: 15993060
[TBL] [Abstract][Full Text] [Related]
31. Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: improving oral biovailability.
Tong Y; Przytulinska M; Tao ZF; Bouska J; Stewart KD; Park C; Li G; Claiborne A; Kovar P; Chen Z; Merta PJ; Bui MH; Olson A; Osterling D; Zhang H; Sham HL; Rosenberg SH; Sowin TJ; Lin NH
Bioorg Med Chem Lett; 2007 Oct; 17(20):5665-70. PubMed ID: 17768051
[TBL] [Abstract][Full Text] [Related]
32. Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.
Foloppe N; Fisher LM; Howes R; Kierstan P; Potter A; Robertson AG; Surgenor AE
J Med Chem; 2005 Jun; 48(13):4332-45. PubMed ID: 15974586
[TBL] [Abstract][Full Text] [Related]
33. Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
Wang L; Sullivan GM; Hexamer LA; Hasvold LA; Thalji R; Przytulinska M; Tao ZF; Li G; Chen Z; Xiao Z; Gu WZ; Xue J; Bui MH; Merta P; Kovar P; Bouska JJ; Zhang H; Park C; Stewart KD; Sham HL; Sowin TJ; Rosenberg SH; Lin NH
J Med Chem; 2007 Aug; 50(17):4162-76. PubMed ID: 17658776
[TBL] [Abstract][Full Text] [Related]
34. Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors.
Lin NH; Xia P; Kovar P; Park C; Chen Z; Zhang H; Rosenberg SH; Sham HL
Bioorg Med Chem Lett; 2006 Jan; 16(2):421-6. PubMed ID: 16242328
[TBL] [Abstract][Full Text] [Related]
35. Novel inhibitors of checkpoint kinase 1.
Arrington KL; Dudkin VY
ChemMedChem; 2007 Nov; 2(11):1571-85. PubMed ID: 17854022
[No Abstract] [Full Text] [Related]
36. Kinase-targeted libraries: the design and synthesis of novel, potent, and selective kinase inhibitors.
Akritopoulou-Zanze I; Hajduk PJ
Drug Discov Today; 2009 Mar; 14(5-6):291-7. PubMed ID: 19121409
[TBL] [Abstract][Full Text] [Related]
37. Synthesis of highly substituted dibenzo[b,f]azocines and their evaluation as protein kinase inhibitors.
Arnold LA; Kiplin Guy R
Bioorg Med Chem Lett; 2006 Oct; 16(20):5360-3. PubMed ID: 16890431
[TBL] [Abstract][Full Text] [Related]
38. Inhibitors of checkpoint kinases: from discovery to the clinic.
Janetka JW; Ashwell S; Zabludoff S; Lyne P
Curr Opin Drug Discov Devel; 2007 Jul; 10(4):473-86. PubMed ID: 17659489
[TBL] [Abstract][Full Text] [Related]
39. Synthesis of a series of novel 2,4,5-trisubstituted selenazole compounds as potential PLTP inhibitors.
Ling C; Zheng Z; Jiang XC; Zhong W; Li S
Bioorg Med Chem Lett; 2010 Sep; 20(17):5123-5. PubMed ID: 20667734
[TBL] [Abstract][Full Text] [Related]
40. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent.
Verheijen JC; Richard DJ; Curran K; Kaplan J; Lefever M; Nowak P; Malwitz DJ; Brooijmans N; Toral-Barza L; Zhang WG; Lucas J; Hollander I; Ayral-Kaloustian S; Mansour TS; Yu K; Zask A
J Med Chem; 2009 Dec; 52(24):8010-24. PubMed ID: 19894727
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
