BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

140 related articles for article (PubMed ID: 20675132)

  • 1. Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.
    Owen CP; Shahid I; Lee WY; Ahmed S
    Bioorg Med Chem Lett; 2010 Sep; 20(17):5345-8. PubMed ID: 20675132
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP; Shahid I; Olusanjo MS; Patel CH; Dhanani S; Ahmed S
    J Steroid Biochem Mol Biol; 2008 Jul; 111(1-2):117-27. PubMed ID: 18620055
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).
    Ahmed S; Shahid I; Dhanani S; Owen CP
    Bioorg Med Chem Lett; 2009 Aug; 19(16):4698-701. PubMed ID: 19608417
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha).
    Shahid I; Patel CH; Dhanani S; Owen CP; Ahmed S
    J Steroid Biochem Mol Biol; 2008 May; 110(1-2):18-29. PubMed ID: 18407491
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP; Dhanani S; Patel CH; Shahid I; Ahmed S
    Bioorg Med Chem Lett; 2006 Aug; 16(15):4011-5. PubMed ID: 16750362
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Patel CH; Dhanani S; Owen CP; Ahmed S
    Bioorg Med Chem Lett; 2006 Sep; 16(18):4752-6. PubMed ID: 16870430
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
    Ling YZ; Li JS; Liu Y; Kato K; Klus GT; Brodie A
    J Med Chem; 1997 Sep; 40(20):3297-304. PubMed ID: 9379450
    [TBL] [Abstract][Full Text] [Related]  

  • 8. YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.
    Ideyama Y; Kudoh M; Tanimoto K; Susaki Y; Nanya T; Nakahara T; Ishikawa H; Fujikura T; Akaza H; Shikama H
    Jpn J Pharmacol; 1999 Feb; 79(2):213-20. PubMed ID: 10202857
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).
    Hartmann RW; Hector M; Wachall BG; Palusczak A; Palzer M; Huch V; Veith M
    J Med Chem; 2000 Nov; 43(23):4437-45. PubMed ID: 11087568
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
    Njar VC; Kato K; Nnane IP; Grigoryev DN; Long BJ; Brodie AM
    J Med Chem; 1998 Mar; 41(6):902-12. PubMed ID: 9526564
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Determination of 17α-hydroxylase-C17,20-lyase (P45017α) enzyme activities and their inhibition by selected steroidal picolyl and picolinylidene compounds.
    Szabó N; Ajduković JJ; Djurendić EA; Sakač MN; Ignáth I; Gardi J; Mahmoud G; Klisurić OR; Jovanović-Šanta S; Penov Gaši KM; Szécsi M
    Acta Biol Hung; 2015 Mar; 66(1):41-51. PubMed ID: 25740437
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
    Hu Q; Negri M; Jahn-Hoffmann K; Zhuang Y; Olgen S; Bartels M; Müller-Vieira U; Lauterbach T; Hartmann RW
    Bioorg Med Chem; 2008 Aug; 16(16):7715-27. PubMed ID: 18674917
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.
    Jagusch C; Negri M; Hille UE; Hu Q; Bartels M; Jahn-Hoffmann K; Pinto-Bazurco Mendieta MA; Rodenwaldt B; Müller-Vieira U; Schmidt D; Lauterbach T; Recanatini M; Cavalli A; Hartmann RW
    Bioorg Med Chem; 2008 Feb; 16(4):1992-2010. PubMed ID: 18061460
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Steroselective synthesis of some steroidal oxazolines, as novel potential inhibitors of 17alpha-hydroxylase-C17,20-lyase.
    Ondré D; Wölfling J; Tóth I; Szécsi M; Julesz J; Schneider G
    Steroids; 2009; 74(13-14):1025-32. PubMed ID: 19666042
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure-activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors.
    Kaku T; Tsujimoto S; Matsunaga N; Tanaka T; Hara T; Yamaoka M; Kusaka M; Tasaka A
    Bioorg Med Chem; 2011 Apr; 19(7):2428-42. PubMed ID: 21429754
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.
    Haidar S; Ehmer PB; Barassin S; Batzl-Hartmann C; Hartmann RW
    J Steroid Biochem Mol Biol; 2003 Apr; 84(5):555-62. PubMed ID: 12767280
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase.
    Stefanachi A; Favia AD; Nicolotti O; Leonetti F; Pisani L; Catto M; Zimmer C; Hartmann RW; Carotti A
    J Med Chem; 2011 Mar; 54(6):1613-25. PubMed ID: 21341743
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.
    Li JS; Li Y; Son C; Brodie AM
    J Med Chem; 1996 Oct; 39(21):4335-9. PubMed ID: 8863811
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
    Recanatini M; Bisi A; Cavalli A; Belluti F; Gobbi S; Rampa A; Valenti P; Palzer M; Palusczak A; Hartmann RW
    J Med Chem; 2001 Mar; 44(5):672-80. PubMed ID: 11262078
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Neighboring group participation Part 17 Stereoselective synthesis of some steroidal 2-oxazolidones, as novel potential inhibitors of 17alpha-hydroxylase-C(17,20)-lyase.
    Ondré D; Wölfling J; Iványi Z; Schneider G; Tóth I; Szécsi M; Julesz J
    Steroids; 2008 Dec; 73(14):1375-84. PubMed ID: 18652838
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.