172 related articles for article (PubMed ID: 20677779)
1. Product analysis and inhibition studies of a causative Asn to Ser variant of 4-hydroxyphenylpyruvate dioxygenase suggest a simple route to the treatment of Hawkinsinuria.
Brownlee JM; Heinz B; Bates J; Moran GR
Biochemistry; 2010 Aug; 49(33):7218-26. PubMed ID: 20677779
[TBL] [Abstract][Full Text] [Related]
2. Interaction of (4-hydroxyphenyl)pyruvate dioxygenase with the specific inhibitor 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione.
Kavana M; Moran GR
Biochemistry; 2003 Sep; 42(34):10238-45. PubMed ID: 12939152
[TBL] [Abstract][Full Text] [Related]
3. Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dione.
Ellis MK; Whitfield AC; Gowans LA; Auton TR; Provan WM; Lock EA; Smith LL
Toxicol Appl Pharmacol; 1995 Jul; 133(1):12-9. PubMed ID: 7597701
[TBL] [Abstract][Full Text] [Related]
4. Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC.
Brownlee JM; Johnson-Winters K; Harrison DH; Moran GR
Biochemistry; 2004 Jun; 43(21):6370-7. PubMed ID: 15157070
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-[2-nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione.
Molchanov S; Gryff-Keller A
Acta Biochim Pol; 2009; 56(3):447-54. PubMed ID: 19621095
[TBL] [Abstract][Full Text] [Related]
6. Spectroscopic and computational studies of NTBC bound to the non-heme iron enzyme (4-hydroxyphenyl)pyruvate dioxygenase: active site contributions to drug inhibition.
Neidig ML; Decker A; Kavana M; Moran GR; Solomon EI
Biochem Biophys Res Commun; 2005 Dec; 338(1):206-14. PubMed ID: 16197918
[TBL] [Abstract][Full Text] [Related]
7. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria.
Tomoeda K; Awata H; Matsuura T; Matsuda I; Ploechl E; Milovac T; Boneh A; Scott CR; Danks DM; Endo F
Mol Genet Metab; 2000 Nov; 71(3):506-10. PubMed ID: 11073718
[TBL] [Abstract][Full Text] [Related]
8. Evidence for the mechanism of hydroxylation by 4-hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase from intermediate partitioning in active site variants.
Shah DD; Conrad JA; Heinz B; Brownlee JM; Moran GR
Biochemistry; 2011 Sep; 50(35):7694-704. PubMed ID: 21815644
[TBL] [Abstract][Full Text] [Related]
9. 4-Hydroxyphenylpyruvate dioxygenase.
Moran GR
Arch Biochem Biophys; 2005 Jan; 433(1):117-28. PubMed ID: 15581571
[TBL] [Abstract][Full Text] [Related]
10. Hydrophobicity-oriented drug design (HODD) of new human 4-hydroxyphenylpyruvate dioxygenase inhibitors.
Ndikuryayo F; Kang WM; Wu FX; Yang WC; Yang GF
Eur J Med Chem; 2019 Mar; 166():22-31. PubMed ID: 30684868
[TBL] [Abstract][Full Text] [Related]
11. Manifestation of hawkinsinuria in a patient compound heterozygous for hawkinsinuria and tyrosinemia III.
Item CB; Mihalek I; Lichtarge O; Jalan A; Vodopiutz J; Muhl A; Bodamer OA
Mol Genet Metab; 2007 Aug; 91(4):379-83. PubMed ID: 17560158
[TBL] [Abstract][Full Text] [Related]
12. Identification of a novel 4-hydroxyphenylpyruvate dioxygenase from the soil metagenome.
Lee CM; Yeo YS; Lee JH; Kim SJ; Kim JB; Han NS; Koo BS; Yoon SH
Biochem Biophys Res Commun; 2008 May; 370(2):322-6. PubMed ID: 18381065
[TBL] [Abstract][Full Text] [Related]
13. Tissue distribution of 2-(2-nitro-4-trifluoromethylbenzoyl)cyclohexane-1-3-dione (NTBC): effect on enzymes involved in tyrosine catabolism and relevance to ocular toxicity in the rat.
Lock EA; Gaskin P; Ellis MK; Provan WM; Robinson M; Smith LL; Prisbylla MP; Mutter LC
Toxicol Appl Pharmacol; 1996 Dec; 141(2):439-47. PubMed ID: 8975769
[TBL] [Abstract][Full Text] [Related]
14. Catalytic, noncatalytic, and inhibitory phenomena: kinetic analysis of (4-hydroxyphenyl)pyruvate dioxygenase from Arabidopsis thaliana.
Purpero VM; Moran GR
Biochemistry; 2006 May; 45(19):6044-55. PubMed ID: 16681377
[TBL] [Abstract][Full Text] [Related]
15. The effect of a low-protein diet and dietary supplementation of threonine on tyrosine and 2-(2-nitro-4-trifluoromethylbenzoyl) cyclohexane-1,3-dione-induced corneal lesions, the extent of tyrosinemia, and the activity of enzymes involved in tyrosine catabolism in the rat.
Lock EA; Gaskin P; Ellis MK; Robinson M; Provan WM; Smith LL
Toxicol Appl Pharmacol; 1998 May; 150(1):125-32. PubMed ID: 9630461
[TBL] [Abstract][Full Text] [Related]
16. Tyrosinemia I, a model for human diseases mediated by 2-oxoacid-utilizing dioxygenases: hepatotoxin suppression by NTBC does not normalize hepatic collagen metabolism.
Hanauske-Abel HM; Popowicz A; Remotti H; Newfield RS; Levy J
J Pediatr Gastroenterol Nutr; 2002 Jul; 35(1):73-8. PubMed ID: 12142814
[TBL] [Abstract][Full Text] [Related]
17. Pharmacokinetics and pharmacodynamics of NTBC (2-(2-nitro-4-fluoromethylbenzoyl)-1,3-cyclohexanedione) and mesotrione, inhibitors of 4-hydroxyphenyl pyruvate dioxygenase (HPPD) following a single dose to healthy male volunteers.
Hall MG; Wilks MF; Provan WM; Eksborg S; Lumholtz B
Br J Clin Pharmacol; 2001 Aug; 52(2):169-77. PubMed ID: 11488774
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors.
Xu YL; Lin HY; Ruan X; Yang SG; Hao GF; Yang WC; Yang GF
Eur J Med Chem; 2015 Mar; 92():427-38. PubMed ID: 25590863
[TBL] [Abstract][Full Text] [Related]
19. Inhibition of para-Hydroxyphenylpyruvate Dioxygenase by Analogues of the Herbicide Nitisinone As a Strategy to Decrease Homogentisic Acid Levels, the Causative Agent of Alkaptonuria.
Laschi M; Bernardini G; Dreassi E; Millucci L; Geminiani M; Braconi D; Marzocchi B; Botta M; Manetti F; Santucci A
ChemMedChem; 2016 Apr; 11(7):674-8. PubMed ID: 26947423
[TBL] [Abstract][Full Text] [Related]
20. Isolation of herbicide-resistant 4-hydroxyphenylpyruvate dioxygenase from cultured Coptis japonica cells.
Liang Y; Minami H; Sato F
Biosci Biotechnol Biochem; 2008 Nov; 72(11):3059-62. PubMed ID: 18997404
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
