BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

75 related articles for article (PubMed ID: 20684600)

  • 1. Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.
    Abbenante G; Becker B; Blanc S; Clark C; Condie G; Fraser G; Grathwohl M; Halliday J; Henderson S; Lam A; Liu L; Mann M; Muldoon C; Pearson A; Premraj R; Ramsdale T; Rossetti T; Schafer K; Le Thanh G; Tometzki G; Vari F; Verquin G; Waanders J; West M; Wimmer N; Yau A; Zuegg J; Meutermans W
    J Med Chem; 2010 Aug; 53(15):5576-86. PubMed ID: 20684600
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.
    Tamamura H; Araki T; Ueda S; Wang Z; Oishi S; Esaka A; Trent JO; Nakashima H; Yamamoto N; Peiper SC; Otaka A; Fujii N
    J Med Chem; 2005 May; 48(9):3280-9. PubMed ID: 15857134
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.
    Clark DE; Higgs C; Wren SP; Dyke HJ; Wong M; Norman D; Lockey PM; Roach AG
    J Med Chem; 2004 Jul; 47(16):3962-71. PubMed ID: 15267235
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A versatile synthetic approach toward diversity libraries using monosaccharide scaffolds.
    Thanh GL; Abbenante G; Adamson G; Becker B; Clark C; Condie G; Falzun T; Grathwohl M; Gupta P; Hanson M; Huynh N; Katavic P; Kuipers K; Lam A; Liu L; Mann M; Mason J; McKeveney D; Muldoon C; Pearson A; Rajaratnam P; Ryan S; Tometzki G; Verquin G; Waanders J; West M; Wilcox N; Wimmer N; Yau A; Zuegg J; Meutermans W
    J Org Chem; 2010 Jan; 75(1):197-203. PubMed ID: 19961235
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.
    Cavasotto CN; Orry AJ; Murgolo NJ; Czarniecki MF; Kocsi SA; Hawes BE; O'Neill KA; Hine H; Burton MS; Voigt JH; Abagyan RA; Bayne ML; Monsma FJ
    J Med Chem; 2008 Feb; 51(3):581-8. PubMed ID: 18198821
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.
    Erchegyi J; Penke B; Simon L; Michaelson S; Wenger S; Waser B; Cescato R; Schaer JC; Reubi JC; Rivier J
    J Med Chem; 2003 Dec; 46(26):5587-96. PubMed ID: 14667213
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.
    Ulven T; Frimurer TM; Receveur JM; Little PB; Rist O; Nørregaard PK; Högberg T
    J Med Chem; 2005 Sep; 48(18):5684-97. PubMed ID: 16134937
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of a new class of macrocyclic antagonists to the human motilin receptor.
    Marsault E; Hoveyda HR; Peterson ML; Saint-Louis C; Landry A; Vézina M; Ouellet L; Wang Z; Ramaseshan M; Beaubien S; Benakli K; Beauchemin S; Déziel R; Peeters T; Fraser GL
    J Med Chem; 2006 Nov; 49(24):7190-7. PubMed ID: 17125271
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.
    D'Addona D; Carotenuto A; Novellino E; Piccand V; Reubi JC; Di Cianni A; Gori F; Papini AM; Ginanneschi M
    J Med Chem; 2008 Feb; 51(3):512-20. PubMed ID: 18210999
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.
    Hirschmann R; Hynes J; Cichy-Knight MA; van Rijn RD; Sprengeler PA; Spoors PG; Shakespeare WC; Pietranico-Cole S; Barbosa J; Liu J; Yao W; Rohrer S; Smith AB
    J Med Chem; 1998 Apr; 41(9):1382-91. PubMed ID: 9554871
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.
    Lewis I; Bauer W; Albert R; Chandramouli N; Pless J; Weckbecker G; Bruns C
    J Med Chem; 2003 Jun; 46(12):2334-44. PubMed ID: 12773038
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.
    Guo T; Gu H; Hobbs DW; Busler DE; Rokosz LL
    Bioorg Med Chem Lett; 2007 Mar; 17(6):1718-21. PubMed ID: 17251014
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
    McBriar MD; Guzik H; Shapiro S; Paruchova J; Xu R; Palani A; Clader JW; Cox K; Greenlee WJ; Hawes BE; Kowalski TJ; O'neill K; Spar BD; Weig B; Weston DJ; Farley C; Cook J
    J Med Chem; 2006 Apr; 49(7):2294-310. PubMed ID: 16570926
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Introduction of a cis-prolyl mimic in position 7 of the peptide hormone oxytocin does not result in antagonistic activity.
    Wittelsberger A; Patiny L; Slaninova J; Barberis C; Mutter M
    J Med Chem; 2005 Oct; 48(21):6553-62. PubMed ID: 16220972
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.
    Rivier J; Erchegyi J; Hoeger C; Miller C; Low W; Wenger S; Waser B; Schaer JC; Reubi JC
    J Med Chem; 2003 Dec; 46(26):5579-86. PubMed ID: 14667212
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.
    Ueda S; Oishi S; Wang ZX; Araki T; Tamamura H; Cluzeau J; Ohno H; Kusano S; Nakashima H; Trent JO; Peiper SC; Fujii N
    J Med Chem; 2007 Jan; 50(2):192-8. PubMed ID: 17228861
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.
    Orsini MJ; Klein MA; Beavers MP; Connolly PJ; Middleton SA; Mayo KH
    J Med Chem; 2007 Feb; 50(3):462-71. PubMed ID: 17266198
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.
    Erchegyi J; Waser B; Schaer JC; Cescato R; Brazeau JF; Rivier J; Reubi JC
    J Med Chem; 2003 Dec; 46(26):5597-605. PubMed ID: 14667214
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pharmacophore-based design of sphingosine 1-phosphate-3 receptor antagonists that include a 3,4-dialkoxybenzophenone scaffold.
    Koide Y; Uemoto K; Hasegawa T; Sada T; Murakami A; Takasugi H; Sakurai A; Mochizuki N; Takahashi A; Nishida A
    J Med Chem; 2007 Feb; 50(3):442-54. PubMed ID: 17266196
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-activity relationship study on artificial CXCR4 ligands possessing the cyclic pentapeptide scaffold: the exploration of amino acid residues of pentapeptides by substitutions of several aromatic amino acids.
    Tanaka T; Nomura W; Narumi T; Esaka A; Oishi S; Ohashi N; Itotani K; Evans BJ; Wang ZX; Peiper SC; Fujii N; Tamamura H
    Org Biomol Chem; 2009 Sep; 7(18):3805-9. PubMed ID: 19707686
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 4.