These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
202 related articles for article (PubMed ID: 20701311)
1. Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase. Tsai PC; Bigley A; Li Y; Ghanem E; Cadieux CL; Kasten SA; Reeves TE; Cerasoli DM; Raushel FM Biochemistry; 2010 Sep; 49(37):7978-87. PubMed ID: 20701311 [TBL] [Abstract][Full Text] [Related]
2. Enzymes for the homeland defense: optimizing phosphotriesterase for the hydrolysis of organophosphate nerve agents. Tsai PC; Fox N; Bigley AN; Harvey SP; Barondeau DP; Raushel FM Biochemistry; 2012 Aug; 51(32):6463-75. PubMed ID: 22809162 [TBL] [Abstract][Full Text] [Related]
3. Substrate Analogues for the Enzyme-Catalyzed Detoxification of the Organophosphate Nerve Agents-Sarin, Soman, and Cyclosarin. Bigley AN; Harvey SP; Narindoshvili T; Raushel FM Biochemistry; 2021 Sep; 60(38):2875-2887. PubMed ID: 34494832 [TBL] [Abstract][Full Text] [Related]
4. Overcoming the Challenges of Enzyme Evolution To Adapt Phosphotriesterase for V-Agent Decontamination. Bigley AN; Desormeaux E; Xiang DF; Bae SY; Harvey SP; Raushel FM Biochemistry; 2019 Apr; 58(15):2039-2053. PubMed ID: 30893549 [TBL] [Abstract][Full Text] [Related]
5. Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase. Tsai PC; Fan Y; Kim J; Yang L; Almo SC; Gao YQ; Raushel FM Biochemistry; 2010 Sep; 49(37):7988-97. PubMed ID: 20695627 [TBL] [Abstract][Full Text] [Related]
6. Variants of Phosphotriesterase for the Enhanced Detoxification of the Chemical Warfare Agent VR. Bigley AN; Mabanglo MF; Harvey SP; Raushel FM Biochemistry; 2015 Sep; 54(35):5502-12. PubMed ID: 26274608 [TBL] [Abstract][Full Text] [Related]
7. The evolution of phosphotriesterase for decontamination and detoxification of organophosphorus chemical warfare agents. Bigley AN; Raushel FM Chem Biol Interact; 2019 Aug; 308():80-88. PubMed ID: 31100274 [TBL] [Abstract][Full Text] [Related]
8. Enzymatic neutralization of the chemical warfare agent VX: evolution of phosphotriesterase for phosphorothiolate hydrolysis. Bigley AN; Xu C; Henderson TJ; Harvey SP; Raushel FM J Am Chem Soc; 2013 Jul; 135(28):10426-32. PubMed ID: 23789980 [TBL] [Abstract][Full Text] [Related]
9. Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase. Barakat NH; Zheng X; Gilley CB; MacDonald M; Okolotowicz K; Cashman JR; Vyas S; Beck JM; Hadad CM; Zhang J Chem Res Toxicol; 2009 Oct; 22(10):1669-79. PubMed ID: 19715346 [TBL] [Abstract][Full Text] [Related]
10. Detoxification of organophosphate nerve agents by bacterial phosphotriesterase. Ghanem E; Raushel FM Toxicol Appl Pharmacol; 2005 Sep; 207(2 Suppl):459-70. PubMed ID: 15982683 [TBL] [Abstract][Full Text] [Related]
11. Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro. Goldsmith M; Eckstein S; Ashani Y; Greisen P; Leader H; Sussman JL; Aggarwal N; Ovchinnikov S; Tawfik DS; Baker D; Thiermann H; Worek F Arch Toxicol; 2016 Nov; 90(11):2711-2724. PubMed ID: 26612364 [TBL] [Abstract][Full Text] [Related]
12. Hydrolysis of chiral organophosphorus compounds by phosphotriesterases and mammalian paraoxonase-1. Monroy-Noyola A; Almenares-Lopez D; Gisbert EV Front Biosci (Landmark Ed); 2021 Jan; 26(4):744-770. PubMed ID: 33049692 [TBL] [Abstract][Full Text] [Related]
13. Molecular Docking, Metal Substitution and Hydrolysis Reaction of Chiral Substrates of Phosphotriesterase. de Castro AA; Caetano MS; Silva TC; Mancini DT; Rocha EP; da Cunha EF; Ramalho TC Comb Chem High Throughput Screen; 2016; 19(4):334-44. PubMed ID: 27012528 [TBL] [Abstract][Full Text] [Related]
14. Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters. Briseño-Roa L; Timperley CM; Griffiths AD; Fersht AR Protein Eng Des Sel; 2011 Jan; 24(1-2):151-9. PubMed ID: 21037279 [TBL] [Abstract][Full Text] [Related]
15. Interrogation of the Substrate Profile and Catalytic Properties of the Phosphotriesterase from Sphingobium sp. Strain TCM1: An Enzyme Capable of Hydrolyzing Organophosphate Flame Retardants and Plasticizers. Xiang DF; Bigley AN; Ren Z; Xue H; Hull KG; Romo D; Raushel FM Biochemistry; 2015 Dec; 54(51):7539-49. PubMed ID: 26629649 [TBL] [Abstract][Full Text] [Related]
16. Reversed enantioselectivity of diisopropyl fluorophosphatase against organophosphorus nerve agents by rational design. Melzer M; Chen JC; Heidenreich A; Gäb J; Koller M; Kehe K; Blum MM J Am Chem Soc; 2009 Dec; 131(47):17226-32. PubMed ID: 19894712 [TBL] [Abstract][Full Text] [Related]
17. Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study. Worek F; Seeger T; Reiter G; Goldsmith M; Ashani Y; Leader H; Sussman JL; Aggarwal N; Thiermann H; Tawfik DS Toxicol Lett; 2014 Nov; 231(1):45-54. PubMed ID: 25195526 [TBL] [Abstract][Full Text] [Related]
18. Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site. Hill CM; Li WS; Thoden JB; Holden HM; Raushel FM J Am Chem Soc; 2003 Jul; 125(30):8990-1. PubMed ID: 15369336 [TBL] [Abstract][Full Text] [Related]
19. Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues. Chen-Goodspeed M; Sogorb MA; Wu F; Raushel FM Biochemistry; 2001 Feb; 40(5):1332-9. PubMed ID: 11170460 [TBL] [Abstract][Full Text] [Related]
20. Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents. Trovaslet-Leroy M; Musilova L; Renault F; Brazzolotto X; Misik J; Novotny L; Froment MT; Gillon E; Loiodice M; Verdier L; Masson P; Rochu D; Jun D; Nachon F Toxicol Lett; 2011 Sep; 206(1):14-23. PubMed ID: 21683774 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]