608 related articles for article (PubMed ID: 20738147)
1. Free-radical ring closure to conformationally locked α-L-carba-LNAs and synthesis of their oligos: nuclease stability, target RNA specificity, and elicitation of RNase H.
Li Q; Yuan F; Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2010 Sep; 75(18):6122-40. PubMed ID: 20738147
[TBL] [Abstract][Full Text] [Related]
2. Carba-LNA-5MeC/A/G/T modified oligos show nucleobase-specific modulation of 3'-exonuclease activity, thermodynamic stability, RNA selectivity, and RNase H elicitation: synthesis and biochemistry.
Upadhayaya R; Deshpande SG; Li Q; Kardile RA; Sayyed AY; Kshirsagar EK; Salunke RV; Dixit SS; Zhou C; Földesi A; Chattopadhyaya J
J Org Chem; 2011 Jun; 76(11):4408-31. PubMed ID: 21500818
[TBL] [Abstract][Full Text] [Related]
3. Synthesis of conformationally locked Carba-LNAs through intramolecular free-radical addition to C=N. Electrostatic and steric implication of the carba-LNA substituents in the modified oligos for nuclease and thermodynamic stabilities.
Xu J; Liu Y; Dupouy C; Chattopadhyaya J
J Org Chem; 2009 Sep; 74(17):6534-54. PubMed ID: 19670835
[TBL] [Abstract][Full Text] [Related]
4. Double sugar and phosphate backbone-constrained nucleotides: synthesis, structure, stability, and their incorporation into oligodeoxynucleotides.
Zhou C; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 May; 74(9):3248-65. PubMed ID: 19348480
[TBL] [Abstract][Full Text] [Related]
5. Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2'-alkoxy modified oligonucleotides.
Honcharenko D; Barman J; Varghese OP; Chattopadhyaya J
Biochemistry; 2007 May; 46(19):5635-46. PubMed ID: 17411072
[TBL] [Abstract][Full Text] [Related]
6. Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.
Zhou C; Liu Y; Andaloussi M; Badgujar N; Plashkevych O; Chattopadhyaya J
J Org Chem; 2009 Jan; 74(1):118-34. PubMed ID: 19055352
[TBL] [Abstract][Full Text] [Related]
7. Five- and six-membered conformationally locked 2',4'-carbocyclic ribo-thymidines: synthesis, structure, and biochemical studies.
Srivastava P; Barman J; Pathmasiri W; Plashkevych O; Wenska M; Chattopadhyaya J
J Am Chem Soc; 2007 Jul; 129(26):8362-79. PubMed ID: 17552524
[TBL] [Abstract][Full Text] [Related]
8. Synthesis of 2',4'-propylene-bridged (carba-ENA) thymidine and its analogues: the engineering of electrostatic and steric effects at the bottom of the minor groove for nuclease and thermodynamic stabilities and elicitation of RNase H.
Liu Y; Xu J; Karimiahmadabadi M; Zhou C; Chattopadhyaya J
J Org Chem; 2010 Nov; 75(21):7112-28. PubMed ID: 20929200
[TBL] [Abstract][Full Text] [Related]
9. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?
Plashkevych O; Li Q; Chattopadhyaya J
Mol Biosyst; 2017 May; 13(5):921-938. PubMed ID: 28352859
[TBL] [Abstract][Full Text] [Related]
10. Conformationally-2',4'-locked Aza-ENA and carbocyclic ribo-thymidine.
Chattopadhyaya J
Nucleic Acids Symp Ser (Oxf); 2007; (51):69-70. PubMed ID: 18029590
[TBL] [Abstract][Full Text] [Related]
11. Why Carba-LNA-modified oligonucleotides show considerably improved 3'-exonuclease stability compared to that of the LNA modified or the native counterparts: A Michaelis-Menten kinetic analysis.
Zhou C; Chattopadhyaya J
J Org Chem; 2010 Apr; 75(7):2341-9. PubMed ID: 20225808
[TBL] [Abstract][Full Text] [Related]
12. Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer.
Fluiter K; Mook OR; Vreijling J; Langkjaer N; Højland T; Wengel J; Baas F
Mol Biosyst; 2009 Aug; 5(8):838-43. PubMed ID: 19603119
[TBL] [Abstract][Full Text] [Related]
13. Conformationally constrained 2'-N,4'-C-ethylene-bridged thymidine (aza-ENA-T): synthesis, structure, physical, and biochemical studies of aza-ENA-T-modified oligonucleotides.
Varghese OP; Barman J; Pathmasiri W; Plashkevych O; Honcharenko D; Chattopadhyaya J
J Am Chem Soc; 2006 Nov; 128(47):15173-87. PubMed ID: 17117869
[TBL] [Abstract][Full Text] [Related]
14. On the in vitro and in vivo properties of four locked nucleic acid nucleotides incorporated into an anti-H-Ras antisense oligonucleotide.
Fluiter K; Frieden M; Vreijling J; Rosenbohm C; De Wissel MB; Christensen SM; Koch T; Ørum H; Baas F
Chembiochem; 2005 Jun; 6(6):1104-9. PubMed ID: 15861430
[TBL] [Abstract][Full Text] [Related]
15. Antisense oligonuclotides with oxetane-constrained cytidine enhance heteroduplex stability, and elicit satisfactory RNase H response as well as showing improved resistance to both exo and endonucleases.
Pradeepkumar PI; Amirkhanov NV; Chattopadhyaya J
Org Biomol Chem; 2003 Jan; 1(1):81-92. PubMed ID: 12929393
[TBL] [Abstract][Full Text] [Related]
16. Synthesis, physicochemical and biochemical studies of 1',2'-oxetane constrained adenosine and guanosine modified oligonucleotides, and their comparison with those of the corresponding cytidine and thymidine analogues.
Pradeepkumar PI; Cheruku P; Plashkevych O; Acharya P; Gohil S; Chattopadhyaya J
J Am Chem Soc; 2004 Sep; 126(37):11484-99. PubMed ID: 15366894
[TBL] [Abstract][Full Text] [Related]
17. Carbocyclic C-C Bond Formation: Intramolecular Radical Ring Closure to Yield Diastereomerically Pure (7'S-Me- or 7'R-Me-) Carba-LNA Nucleotide Analogs.
Plashkevych O; Upadhayaya RS; Chattopadhyaya J
Curr Protoc Nucleic Acid Chem; 2017 Jun; 69():4.74.1-4.74.42. PubMed ID: 28628208
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and hybridization studies of 2'-amino-alpha-L-LNA and tetracyclic "locked LNA".
Kumar TS; Madsen AS; Wengel J; Hrdlicka PJ
J Org Chem; 2006 May; 71(11):4188-201. PubMed ID: 16709060
[TBL] [Abstract][Full Text] [Related]
19. Determination of affinity constants of locked nucleic acid (LNA) and DNA duplex formation using label free sensor technology.
Möhrle BP; Kumpf M; Gauglitz G
Analyst; 2005 Dec; 130(12):1634-8. PubMed ID: 16284662
[TBL] [Abstract][Full Text] [Related]
20. Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world.
Christensen NK; Bryld T; Sørensen MD; Arar K; Wengel J; Nielsen P
Chem Commun (Camb); 2004 Feb; (3):282-3. PubMed ID: 14740038
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]