BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 20801651)

  • 1. Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators.
    Bridges TM; Kennedy JP; Hopkins CR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2010 Oct; 20(19):5617-22. PubMed ID: 20801651
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.
    Bridges TM; Kennedy JP; Cho HP; Breininger ML; Gentry PR; Hopkins CR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2010 Jan; 20(2):558-62. PubMed ID: 20004578
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM.
    Bridges TM; Phillip Kennedy J; Noetzel MJ; Breininger ML; Gentry PR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2010 Mar; 20(6):1972-5. PubMed ID: 20156687
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery and structure-activity relationships study of positive allosteric modulators of the M
    Tanaka H; Negoro K; Koike T; Tsukamoto I; Yokoyama K; Maeda J; Inagaki Y; Shimoshige Y; Ino K; Ishizu K; Takahashi T
    Bioorg Med Chem; 2020 Jul; 28(13):115531. PubMed ID: 32386953
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
    Bridges TM; Marlo JE; Niswender CM; Jones CK; Jadhav SB; Gentry PR; Plumley HC; Weaver CD; Conn PJ; Lindsley CW
    J Med Chem; 2009 Jun; 52(11):3445-8. PubMed ID: 19438238
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structure-Activity Relationships of Pan-Gα
    Berizzi AE; Bender AM; Lindsley CW; Conn PJ; Sexton PM; Langmead CJ; Christopoulos A
    ACS Chem Neurosci; 2018 Jul; 9(7):1818-1828. PubMed ID: 29683647
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.
    Sheffler DJ; Sevel C; Le U; Lovell KM; Tarr JC; Carrington SJ; Cho HP; Digby GJ; Niswender CM; Conn PJ; Hopkins CR; Wood MR; Lindsley CW
    Bioorg Med Chem Lett; 2013 Jan; 23(1):223-7. PubMed ID: 23200253
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of ML326: The first sub-micromolar, selective M5 PAM.
    Gentry PR; Bridges TM; Lamsal A; Vinson PN; Smith E; Chase P; Hodder PS; Engers JL; Niswender CM; Daniels JS; Conn PJ; Wood MR; Lindsley CW
    Bioorg Med Chem Lett; 2013 May; 23(10):2996-3000. PubMed ID: 23562060
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Molecular Mechanisms of Action of M5 Muscarinic Acetylcholine Receptor Allosteric Modulators.
    Berizzi AE; Gentry PR; Rueda P; Den Hoedt S; Sexton PM; Langmead CJ; Christopoulos A
    Mol Pharmacol; 2016 Oct; 90(4):427-36. PubMed ID: 27461343
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery and Optimization of Potent and CNS Penetrant M
    Bender AM; Cho HP; Nance KD; Lingenfelter KS; Luscombe VB; Gentry PR; Voigtritter K; Berizzi AE; Sexton PM; Langmead CJ; Christopoulos A; Locuson CW; Bridges TM; Chang S; O'Neill JC; Zhan X; Niswender CM; Jones CK; Conn PJ; Lindsley CW
    ACS Chem Neurosci; 2018 Jul; 9(7):1572-1581. PubMed ID: 29678111
    [TBL] [Abstract][Full Text] [Related]  

  • 11. N-heterocyclic derived M1 positive allosteric modulators.
    Kuduk SD; Di Marco CN; Cofre V; Pitts DR; Ray WJ; Ma L; Wittmann M; Veng L; Seager MA; Koeplinger K; Thompson CD; Hartman GD; Bilodeau MT
    Bioorg Med Chem Lett; 2010 Feb; 20(4):1334-7. PubMed ID: 20097564
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Repositioning Dequalinium as Potent Muscarinic Allosteric Ligand by Combining Virtual Screening Campaigns and Experimental Binding Assays.
    Mazzolari A; Gervasoni S; Pedretti A; Fumagalli L; Matucci R; Vistoli G
    Int J Mol Sci; 2020 Aug; 21(17):. PubMed ID: 32825082
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).
    Gentry PR; Kokubo M; Bridges TM; Kett NR; Harp JM; Cho HP; Smith E; Chase P; Hodder PS; Niswender CM; Daniels JS; Conn PJ; Wood MR; Lindsley CW
    J Med Chem; 2013 Nov; 56(22):9351-5. PubMed ID: 24164599
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M
    Dallagnol JCC; Khajehali E; van der Westhuizen ET; Jörg M; Valant C; Gonçalves AG; Capuano B; Christopoulos A; Scammells PJ
    J Med Chem; 2018 Apr; 61(7):2875-2894. PubMed ID: 29544056
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators.
    Niswender CM; Lebois EP; Luo Q; Kim K; Muchalski H; Yin H; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2008 Oct; 18(20):5626-30. PubMed ID: 18793851
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The discovery of VU0486846: steep SAR from a series of M
    Bertron JL; Cho HP; Garcia-Barrantes PM; Panarese JD; Salovich JM; Nance KD; Engers DW; Rook JM; Blobaum AL; Niswender CM; Stauffer SR; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2018 Jul; 28(12):2175-2179. PubMed ID: 29754948
    [TBL] [Abstract][Full Text] [Related]  

  • 17. 4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.
    Mistry SN; Jörg M; Lim H; Vinh NB; Sexton PM; Capuano B; Christopoulos A; Lane JR; Scammells PJ
    J Med Chem; 2016 Jan; 59(1):388-409. PubMed ID: 26624844
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis of novel and functionally selective non-competitive muscarinic antagonists as chemical probes.
    Boulos JF; Jakubik J; Boulos JM; Randakova A; Momirov J
    Chem Biol Drug Des; 2018 Jan; 91(1):93-104. PubMed ID: 28646631
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4). Part II: Challenges in hit-to-lead.
    Williams R; Niswender CM; Luo Q; Le U; Conn PJ; Lindsley CW
    Bioorg Med Chem Lett; 2009 Feb; 19(3):962-6. PubMed ID: 19097893
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.
    Miao Y; Goldfeld DA; Moo EV; Sexton PM; Christopoulos A; McCammon JA; Valant C
    Proc Natl Acad Sci U S A; 2016 Sep; 113(38):E5675-84. PubMed ID: 27601651
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.