211 related articles for article (PubMed ID: 20801881)
1. An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1.
Dinkova-Kostova AT; Talalay P; Sharkey J; Zhang Y; Holtzclaw WD; Wang XJ; David E; Schiavoni KH; Finlayson S; Mierke DF; Honda T
J Biol Chem; 2010 Oct; 285(44):33747-55. PubMed ID: 20801881
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, molecular modeling and NAD(P)H:quinone oxidoreductase 1 inducer activity of novel cyanoenone and enone benzenesulfonamides.
Ghorab MM; Higgins M; Alsaid MS; Arafa RK; Shahat AA; Dinkova-Kostova AT
J Enzyme Inhib Med Chem; 2014 Dec; 29(6):840-5. PubMed ID: 24417210
[TBL] [Abstract][Full Text] [Related]
3. Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy.
Kalra S; Knatko EV; Zhang Y; Honda T; Yamamoto M; Dinkova-Kostova AT
Cancer Prev Res (Phila); 2012 Jul; 5(7):973-81. PubMed ID: 22659146
[TBL] [Abstract][Full Text] [Related]
4. The cytoprotective role of the Keap1-Nrf2 pathway.
Baird L; Dinkova-Kostova AT
Arch Toxicol; 2011 Apr; 85(4):241-72. PubMed ID: 21365312
[TBL] [Abstract][Full Text] [Related]
5. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
Uruno A; Motohashi H
Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
[TBL] [Abstract][Full Text] [Related]
6. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system.
Takaya K; Suzuki T; Motohashi H; Onodera K; Satomi S; Kensler TW; Yamamoto M
Free Radic Biol Med; 2012 Aug; 53(4):817-27. PubMed ID: 22732183
[TBL] [Abstract][Full Text] [Related]
7. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress.
Dinkova-Kostova AT; Liby KT; Stephenson KK; Holtzclaw WD; Gao X; Suh N; Williams C; Risingsong R; Honda T; Gribble GW; Sporn MB; Talalay P
Proc Natl Acad Sci U S A; 2005 Mar; 102(12):4584-9. PubMed ID: 15767573
[TBL] [Abstract][Full Text] [Related]
8. New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase.
Li W; Zheng S; Higgins M; Morra RP; Mendis AT; Chien CW; Ojima I; Mierke DF; Dinkova-Kostova AT; Honda T
J Med Chem; 2015 Jun; 58(11):4738-48. PubMed ID: 25965897
[TBL] [Abstract][Full Text] [Related]
9. Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation.
Kim S; Lee HG; Park SA; Kundu JK; Keum YS; Cha YN; Na HK; Surh YJ
PLoS One; 2014; 9(1):e85984. PubMed ID: 24489685
[TBL] [Abstract][Full Text] [Related]
10. Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Taguchi K; Fujikawa N; Komatsu M; Ishii T; Unno M; Akaike T; Motohashi H; Yamamoto M
Proc Natl Acad Sci U S A; 2012 Aug; 109(34):13561-6. PubMed ID: 22872865
[TBL] [Abstract][Full Text] [Related]
11. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Liby K; Yore MM; Roebuck BD; Baumgartner KJ; Honda T; Sundararajan C; Yoshizawa H; Gribble GW; Williams CR; Risingsong R; Royce DB; Dinkova-Kostova AT; Stephenson KK; Egner PA; Yates MS; Groopman JD; Kensler TW; Sporn MB
Cancer Res; 2008 Aug; 68(16):6727-33. PubMed ID: 18701497
[TBL] [Abstract][Full Text] [Related]
12. Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.
Saito R; Suzuki T; Hiramoto K; Asami S; Naganuma E; Suda H; Iso T; Yamamoto H; Morita M; Baird L; Furusawa Y; Negishi T; Ichinose M; Yamamoto M
Mol Cell Biol; 2016 Jan; 36(2):271-84. PubMed ID: 26527616
[TBL] [Abstract][Full Text] [Related]
13. Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone.
Miura T; Shinkai Y; Jiang HY; Iwamoto N; Sumi D; Taguchi K; Yamamoto M; Jinno H; Tanaka-Kagawa T; Cho AK; Kumagai Y
Chem Res Toxicol; 2011 Apr; 24(4):559-67. PubMed ID: 21384861
[TBL] [Abstract][Full Text] [Related]
14. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
Reisman SA; Yeager RL; Yamamoto M; Klaassen CD
Toxicol Sci; 2009 Mar; 108(1):35-47. PubMed ID: 19129213
[TBL] [Abstract][Full Text] [Related]
15. NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives.
Ghorab MM; Alsaid MS; Higgins M; Dinkova-Kostova AT; Shahat AA; Elghazawy NH; Arafa RK
Drug Des Devel Ther; 2016; 10():2515-24. PubMed ID: 27540279
[TBL] [Abstract][Full Text] [Related]
16. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
He X; Chen MG; Lin GX; Ma Q
J Biol Chem; 2006 Aug; 281(33):23620-31. PubMed ID: 16785233
[TBL] [Abstract][Full Text] [Related]
17. Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide.
Dunlap T; Piyankarage SC; Wijewickrama GT; Abdul-Hay S; Vanni M; Litosh V; Luo J; Thatcher GR
Chem Res Toxicol; 2012 Dec; 25(12):2725-36. PubMed ID: 23035985
[TBL] [Abstract][Full Text] [Related]
18. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.
Blake DJ; Singh A; Kombairaju P; Malhotra D; Mariani TJ; Tuder RM; Gabrielson E; Biswal S
Am J Respir Cell Mol Biol; 2010 May; 42(5):524-36. PubMed ID: 19520915
[TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets.
Saito A; Higgins M; Zheng S; Li W; Ojima I; Dinkova-Kostova AT; Honda T
Bioorg Med Chem Lett; 2013 Oct; 23(20):5540-3. PubMed ID: 24018193
[TBL] [Abstract][Full Text] [Related]
20. The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.
Kanzaki H; Shinohara F; Kajiya M; Kodama T
J Biol Chem; 2013 Aug; 288(32):23009-20. PubMed ID: 23801334
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
