BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 20819069)

  • 1. Recent advances in structural studies of the carbonic anhydrase family: the crystal structure of human CA IX and CA XIII.
    Supuran CT; Di Fiore A; Alterio V; Monti SM; De Simone G
    Curr Pharm Des; 2010; 16(29):3246-54. PubMed ID: 20819069
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
    Alterio V; Vitale RM; Monti SM; Pedone C; Scozzafava A; Cecchi A; De Simone G; Supuran CT
    J Am Chem Soc; 2006 Jun; 128(25):8329-35. PubMed ID: 16787097
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.
    Genis C; Sippel KH; Case N; Cao W; Avvaru BS; Tartaglia LJ; Govindasamy L; Tu C; Agbandje-McKenna M; Silverman DN; Rosser CJ; McKenna R
    Biochemistry; 2009 Feb; 48(6):1322-31. PubMed ID: 19170619
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA.
    Tanc M; Carta F; Scozzafava A; Supuran CT
    Org Biomol Chem; 2015 Jan; 13(1):77-80. PubMed ID: 25373598
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Dissecting the inhibition mechanism of cytosolic versus transmembrane carbonic anhydrases by ESR.
    Ciani L; Cecchi A; Temperini C; Supuran CT; Ristori S
    J Phys Chem B; 2009 Oct; 113(42):13998-4005. PubMed ID: 19778001
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.
    Mahon BP; Hendon AM; Driscoll JM; Rankin GM; Poulsen SA; Supuran CT; McKenna R
    Bioorg Med Chem; 2015 Feb; 23(4):849-54. PubMed ID: 25614109
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.
    Gitto R; Agnello S; Ferro S; De Luca L; Vullo D; Brynda J; Mader P; Supuran CT; Chimirri A
    J Med Chem; 2010 Mar; 53(6):2401-8. PubMed ID: 20170095
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
    Mahon BP; Lomelino CL; Ladwig J; Rankin GM; Driscoll JM; Salguero AL; Pinard MA; Vullo D; Supuran CT; Poulsen SA; McKenna R
    J Med Chem; 2015 Aug; 58(16):6630-8. PubMed ID: 26203869
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
    Pinard MA; Boone CD; Rife BD; Supuran CT; McKenna R
    Bioorg Med Chem; 2013 Nov; 21(22):7210-5. PubMed ID: 24090602
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.
    Leitans J; Sprudza A; Tanc M; Vozny I; Zalubovskis R; Tars K; Supuran CT
    Bioorg Med Chem; 2013 Sep; 21(17):5130-8. PubMed ID: 23859774
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.
    Pastorekova S; Casini A; Scozzafava A; Vullo D; Pastorek J; Supuran CT
    Bioorg Med Chem Lett; 2004 Feb; 14(4):869-73. PubMed ID: 15012984
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases.
    Zakšauskas A; Čapkauskaitė E; Jezepčikas L; Linkuvienė V; Kišonaitė M; Smirnov A; Manakova E; Gražulis S; Matulis D
    Eur J Med Chem; 2018 Aug; 156():61-78. PubMed ID: 30006175
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.
    Moeker J; Mahon BP; Bornaghi LF; Vullo D; Supuran CT; McKenna R; Poulsen SA
    J Med Chem; 2014 Oct; 57(20):8635-45. PubMed ID: 25254302
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.
    Sarikaya B; Ceruso M; Carta F; Supuran CT
    Bioorg Med Chem; 2014 Nov; 22(21):5883-90. PubMed ID: 25267005
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.
    Pinard MA; Aggarwal M; Mahon BP; Tu C; McKenna R
    Acta Crystallogr F Struct Biol Commun; 2015 Oct; 71(Pt 10):1352-8. PubMed ID: 26457530
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII.
    D'Ambrosio K; Vitale RM; Dogné JM; Masereel B; Innocenti A; Scozzafava A; De Simone G; Supuran CT
    J Med Chem; 2008 Jun; 51(11):3230-7. PubMed ID: 18481843
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
    Alterio V; Hilvo M; Di Fiore A; Supuran CT; Pan P; Parkkila S; Scaloni A; Pastorek J; Pastorekova S; Pedone C; Scozzafava A; Monti SM; De Simone G
    Proc Natl Acad Sci U S A; 2009 Sep; 106(38):16233-8. PubMed ID: 19805286
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides.
    Pastorekova S; Vullo D; Casini A; Scozzafava A; Pastorek J; Nishimori I; Supuran CT
    J Enzyme Inhib Med Chem; 2005 Jun; 20(3):211-7. PubMed ID: 16119190
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.
    Knaus EE; Innocenti A; Scozzafava A; Supuran CT
    Bioorg Med Chem Lett; 2011 Oct; 21(19):5892-6. PubMed ID: 21852133
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.
    Garaj V; Puccetti L; Fasolis G; Winum JY; Montero JL; Scozzafava A; Vullo D; Innocenti A; Supuran CT
    Bioorg Med Chem Lett; 2005 Jun; 15(12):3102-8. PubMed ID: 15905091
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.