BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

185 related articles for article (PubMed ID: 20822184)

  • 1. Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.
    Liu J; Eaton JB; Caldarone B; Lukas RJ; Kozikowski AP
    J Med Chem; 2010 Oct; 53(19):6973-85. PubMed ID: 20822184
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression.
    Kozikowski AP; Eaton JB; Bajjuri KM; Chellappan SK; Chen Y; Karadi S; He R; Caldarone B; Manzano M; Yuen PW; Lukas RJ
    ChemMedChem; 2009 Aug; 4(8):1279-91. PubMed ID: 19569163
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of isoxazole analogues of sazetidine-A as selective α4β2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.
    Liu J; Yu LF; Eaton JB; Caldarone B; Cavino K; Ruiz C; Terry M; Fedolak A; Wang D; Ghavami A; Lowe DA; Brunner D; Lukas RJ; Kozikowski AP
    J Med Chem; 2011 Oct; 54(20):7280-8. PubMed ID: 21905669
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.
    Zhang Y; Pavlova OA; Chefer SI; Hall AW; Kurian V; Brown LL; Kimes AS; Mukhin AG; Horti AG
    J Med Chem; 2004 May; 47(10):2453-65. PubMed ID: 15115389
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A.
    Liu Y; Paige M; Olson TT; Al-Muhtasib N; Xie T; Hou S; White MP; Cordova A; Guo JL; Kellar KJ; Xiao Y; Brown ML
    Bioorg Med Chem Lett; 2014 Jul; 24(13):2954-6. PubMed ID: 24844195
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
    Sharples CG; Karig G; Simpson GL; Spencer JA; Wright E; Millar NS; Wonnacott S; Gallagher T
    J Med Chem; 2002 Jul; 45(15):3235-45. PubMed ID: 12109907
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Chemistry and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.
    Zhang H; Tückmantel W; Eaton JB; Yuen PW; Yu LF; Bajjuri KM; Fedolak A; Wang D; Ghavami A; Caldarone B; Paterson NE; Lowe DA; Brunner D; Lukas RJ; Kozikowski AP
    J Med Chem; 2012 Jan; 55(2):717-24. PubMed ID: 22171543
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors.
    Vacher B; Bonnaud B; Funes P; Jubault N; Koek W; Assié MB; Cosi C; Kleven M
    J Med Chem; 1999 May; 42(9):1648-60. PubMed ID: 10229633
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sazetidine-A, a novel ligand that desensitizes alpha4beta2 nicotinic acetylcholine receptors without activating them.
    Xiao Y; Fan H; Musachio JL; Wei ZL; Chellappan SK; Kozikowski AP; Kellar KJ
    Mol Pharmacol; 2006 Oct; 70(4):1454-60. PubMed ID: 16857741
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ligand selectivity for the acetylcholine binding site of the rat alpha4beta2 and alpha3beta4 nicotinic subtypes investigated by molecular docking.
    Bisson WH; Scapozza L; Westera G; Mu L; Schubiger PA
    J Med Chem; 2005 Aug; 48(16):5123-30. PubMed ID: 16078832
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed as α4β2-Nicotinic Acetylcholine Receptor Agonists.
    Bolchi C; Valoti E; Gotti C; Fasoli F; Ruggeri P; Fumagalli L; Binda M; Mucchietto V; Sciaccaluga M; Budriesi R; Fucile S; Pallavicini M
    J Med Chem; 2015 Aug; 58(16):6665-77. PubMed ID: 26225816
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent α4β2 nicotinic acetylcholine receptor ligands.
    Scanio MJ; Shi L; Bunnelle WH; Anderson DJ; Helfrich RJ; Malysz J; Thorin-Hagene KK; Van Handel CE; Marsh KC; Lee CH; Gopalakrishnan M
    J Med Chem; 2011 Nov; 54(21):7678-92. PubMed ID: 21962147
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.
    Yenugonda VM; Xiao Y; Levin ED; Rezvani AH; Tran T; Al-Muhtasib N; Sahibzada N; Xie T; Wells C; Slade S; Johnson JE; Dakshanamurthy S; Kong HS; Tomita Y; Liu Y; Paige M; Kellar KJ; Brown ML
    J Med Chem; 2013 Nov; 56(21):8404-21. PubMed ID: 24047231
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
    Yu LF; Tückmantel W; Eaton JB; Caldarone B; Fedolak A; Hanania T; Brunner D; Lukas RJ; Kozikowski AP
    J Med Chem; 2012 Jan; 55(2):812-23. PubMed ID: 22148173
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
    Sippy KB; Anderson DJ; Bunnelle WH; Hutchins CW; Schrimpf MR
    Bioorg Med Chem Lett; 2009 Mar; 19(6):1682-5. PubMed ID: 19232492
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380.
    Caldarone BJ; Wang D; Paterson NE; Manzano M; Fedolak A; Cavino K; Kwan M; Hanania T; Chellappan SK; Kozikowski AP; Olivier B; Picciotto MR; Ghavami A
    Psychopharmacology (Berl); 2011 Sep; 217(2):199-210. PubMed ID: 21487659
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype.
    Matera C; Quadri M; Sciaccaluga M; Pomè DY; Fasoli F; De Amici M; Fucile S; Gotti C; Dallanoce C; Grazioso G
    Eur J Med Chem; 2016 Jan; 108():392-405. PubMed ID: 26706350
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent α4β2- and α6β2-nicotinic acetylcholine receptor partial agonist.
    Bolchi C; Gotti C; Binda M; Fumagalli L; Pucci L; Pistillo F; Vistoli G; Valoti E; Pallavicini M
    J Med Chem; 2011 Nov; 54(21):7588-601. PubMed ID: 21942635
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.
    Ji J; Schrimpf MR; Sippy KB; Bunnelle WH; Li T; Anderson DJ; Faltynek C; Surowy CS; Dyhring T; Ahring PK; Meyer MD
    J Med Chem; 2007 Nov; 50(22):5493-508. PubMed ID: 17929796
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
    Yu LF; Eaton JB; Fedolak A; Zhang HK; Hanania T; Brunner D; Lukas RJ; Kozikowski AP
    J Med Chem; 2012 Nov; 55(22):9998-10009. PubMed ID: 23092294
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.