BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 20823538)

  • 1. Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus.
    Morrow CA; Stamp A; Valkov E; Kobe B; Fraser JA
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2010 Sep; 66(Pt 9):1104-7. PubMed ID: 20823538
    [TBL] [Abstract][Full Text] [Related]  

  • 2. De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans.
    Morrow CA; Valkov E; Stamp A; Chow EW; Lee IR; Wronski A; Williams SJ; Hill JM; Djordjevic JT; Kappler U; Kobe B; Fraser JA
    PLoS Pathog; 2012; 8(10):e1002957. PubMed ID: 23071437
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Purification, crystallization and preliminary X-ray analysis of adenylosuccinate synthetase from the fungal pathogen Cryptococcus neoformans.
    Blundell RD; Williams SJ; Morrow CA; Ericsson DJ; Kobe B; Fraser JA
    Acta Crystallogr Sect F Struct Biol Cryst Commun; 2013 Sep; 69(Pt 9):1033-6. PubMed ID: 23989157
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structures of Tritrichomonasfoetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs: a structural basis for the random-in ordered-out kinetic mechanism.
    Prosise GL; Luecke H
    J Mol Biol; 2003 Feb; 326(2):517-27. PubMed ID: 12559919
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis.
    Gan L; Petsko GA; Hedstrom L
    Biochemistry; 2002 Nov; 41(44):13309-17. PubMed ID: 12403633
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of IMPDH by mycophenolic acid: dissection of forward and reverse pathways using capillary electrophoresis.
    Fleming MA; Chambers SP; Connelly PR; Nimmesgern E; Fox T; Bruzzese FJ; Hoe ST; Fulghum JR; Livingston DJ; Stuver CM; Sintchak MD; Wilson KP; Thomson JA
    Biochemistry; 1996 Jun; 35(22):6990-7. PubMed ID: 8679523
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.
    Sintchak MD; Fleming MA; Futer O; Raybuck SA; Chambers SP; Caron PR; Murcko MA; Wilson KP
    Cell; 1996 Jun; 85(6):921-30. PubMed ID: 8681386
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mycophenolic acid and thiazole adenine dinucleotide inhibition of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: implications on enzyme mechanism.
    Hedstrom L; Wang CC
    Biochemistry; 1990 Jan; 29(4):849-54. PubMed ID: 1971185
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.
    Kummari LK; Butler MS; Furlong E; Blundell R; Nouwens A; Silva AB; Kappler U; Fraser JA; Kobe B; Cooper MA; Robertson AAB
    Bioorg Med Chem; 2018 Nov; 26(20):5408-5419. PubMed ID: 30322754
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid.
    Digits JA; Hedstrom L
    Biochemistry; 1999 Nov; 38(46):15388-97. PubMed ID: 10563825
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effect of mycophenolic acid glucuronide on inosine monophosphate dehydrogenase activity.
    Nowak I; Shaw LM
    Ther Drug Monit; 1997 Jun; 19(3):358-60. PubMed ID: 9200779
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.
    Sintchak MD; Nimmesgern E
    Immunopharmacology; 2000 May; 47(2-3):163-84. PubMed ID: 10878288
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The functional basis of mycophenolic acid resistance in Candida albicans IMP dehydrogenase.
    Köhler GA; Gong X; Bentink S; Theiss S; Pagani GM; Agabian N; Hedstrom L
    J Biol Chem; 2005 Mar; 280(12):11295-302. PubMed ID: 15665003
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Allosteric properties of inosine monophosphate dehydrogenase revealed through the thermodynamics of binding of inosine 5'-monophosphate and mycophenolic acid. Temperature dependent heat capacity of binding as a signature of ligand-coupled conformational equilibria.
    Bruzzese FJ; Connelly PR
    Biochemistry; 1997 Aug; 36(34):10428-38. PubMed ID: 9265623
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A new class of IMP dehydrogenase with a role in self-resistance of mycophenolic acid producing fungi.
    Hansen BG; Genee HJ; Kaas CS; Nielsen JB; Regueira TB; Mortensen UH; Frisvad JC; Patil KR
    BMC Microbiol; 2011 Sep; 11():202. PubMed ID: 21923907
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid.
    Nimmesgern E; Fox T; Fleming MA; Thomson JA
    J Biol Chem; 1996 Aug; 271(32):19421-7. PubMed ID: 8702630
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Acid-base catalysis in the chemical mechanism of inosine monophosphate dehydrogenase.
    Markham GD; Bock CL; Schalk-Hihi C
    Biochemistry; 1999 Apr; 38(14):4433-40. PubMed ID: 10194364
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Isolation and characterization of mycophenolic acid-resistant mutants of inosine-5'-monophosphate dehydrogenase.
    Farazi T; Leichman J; Harris T; Cahoon M; Hedstrom L
    J Biol Chem; 1997 Jan; 272(2):961-5. PubMed ID: 8995388
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A structural determinant of mycophenolic acid resistance in eukaryotic inosine 5'-monophosphate dehydrogenases.
    Freedman R; Yu R; Sarkis AW; Hedstrom L
    Protein Sci; 2020 Mar; 29(3):686-694. PubMed ID: 31675145
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.
    McMillan FM; Cahoon M; White A; Hedstrom L; Petsko GA; Ringe D
    Biochemistry; 2000 Apr; 39(15):4533-42. PubMed ID: 10758003
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.