251 related articles for article (PubMed ID: 20832446)
1. Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism.
Fery Y; Mueller SO; Schrenk D
Toxicology; 2010 Nov; 277(1-3):11-9. PubMed ID: 20832446
[TBL] [Abstract][Full Text] [Related]
2. Technical pentabromodiphenyl ether and hexabromocyclododecane as activators of the pregnane-X-receptor (PXR).
Fery Y; Buschauer I; Salzig C; Lang P; Schrenk D
Toxicology; 2009 Oct; 264(1-2):45-51. PubMed ID: 19631710
[TBL] [Abstract][Full Text] [Related]
3. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors.
Küblbeck J; Reinisalo M; Mustonen R; Honkakoski P
Eur J Pharm Sci; 2010 Jul; 40(4):263-72. PubMed ID: 20381613
[TBL] [Abstract][Full Text] [Related]
4. A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.
Wang H; Faucette S; Sueyoshi T; Moore R; Ferguson S; Negishi M; LeCluyse EL
J Biol Chem; 2003 Apr; 278(16):14146-52. PubMed ID: 12571232
[TBL] [Abstract][Full Text] [Related]
5. Species-specific activation of nuclear receptors correlates with the response of liver drug metabolizing enzymes to EMD 392949 in vitro.
Mueller SO; Fery Y; Tuschl G; Schrenk D
Toxicol Lett; 2010 Mar; 193(1):120-3. PubMed ID: 20035846
[TBL] [Abstract][Full Text] [Related]
6. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.
Casabar RC; Das PC; Dekrey GK; Gardiner CS; Cao Y; Rose RL; Wallace AD
Toxicol Appl Pharmacol; 2010 Jun; 245(3):335-43. PubMed ID: 20361990
[TBL] [Abstract][Full Text] [Related]
7. Stable overexpression of pregnane X receptor in HepG2 cells increases its potential for bioartificial liver application.
Nibourg GA; Huisman MT; van der Hoeven TV; van Gulik TM; Chamuleau RA; Hoekstra R
Liver Transpl; 2010 Sep; 16(9):1075-85. PubMed ID: 20818746
[TBL] [Abstract][Full Text] [Related]
8. Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
LeCluyse EL
Chem Biol Interact; 2001 May; 134(3):283-9. PubMed ID: 11336976
[TBL] [Abstract][Full Text] [Related]
9. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor.
Hoffart E; Ghebreghiorghis L; Nussler AK; Thasler WE; Weiss TS; Schwab M; Burk O
Br J Pharmacol; 2012 Mar; 165(5):1595-608. PubMed ID: 21913896
[TBL] [Abstract][Full Text] [Related]
10. Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells.
Swales K; Plant N; Ayrton A; Hood S; Gibson G
Xenobiotica; 2003 Jul; 33(7):703-16. PubMed ID: 12893520
[TBL] [Abstract][Full Text] [Related]
11. Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.
Takezawa T; Matsunaga T; Aikawa K; Nakamura K; Ohmori S
Drug Metab Pharmacokinet; 2012; 27(4):430-8. PubMed ID: 22333269
[TBL] [Abstract][Full Text] [Related]
12. Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response.
Wei P; Zhang J; Dowhan DH; Han Y; Moore DD
Pharmacogenomics J; 2002; 2(2):117-26. PubMed ID: 12049174
[TBL] [Abstract][Full Text] [Related]
13. Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2.
Rhodes SP; Otten JN; Hingorani GP; Hartley DP; Franklin RB
J Pharmacol Toxicol Methods; 2011; 63(3):223-6. PubMed ID: 21111054
[TBL] [Abstract][Full Text] [Related]
14. The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.
Sugatani J; Yamakawa K; Tonda E; Nishitani S; Yoshinari K; Degawa M; Abe I; Noguchi H; Miwa M
Biochem Pharmacol; 2004 Mar; 67(5):989-1000. PubMed ID: 15104253
[TBL] [Abstract][Full Text] [Related]
15. The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes.
Song X; Xie M; Zhang H; Li Y; Sachdeva K; Yan B
Drug Metab Dispos; 2004 Jan; 32(1):35-42. PubMed ID: 14709618
[TBL] [Abstract][Full Text] [Related]
16. Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Luckert C; Ehlers A; Buhrke T; Seidel A; Lampen A; Hessel S
Toxicol Lett; 2013 Oct; 222(2):180-8. PubMed ID: 23845848
[TBL] [Abstract][Full Text] [Related]
17. Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss).
Wassmur B; Gräns J; Kling P; Celander MC
Aquat Toxicol; 2010 Oct; 100(1):91-100. PubMed ID: 20719396
[TBL] [Abstract][Full Text] [Related]
18. The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators.
Pacyniak EK; Cheng X; Cunningham ML; Crofton K; Klaassen CD; Guo GL
Toxicol Sci; 2007 May; 97(1):94-102. PubMed ID: 17324954
[TBL] [Abstract][Full Text] [Related]
19. Establishment of a stable human cell line, HPL-A3, for use in reporter gene assays of cytochrome P450 3A inducers.
Sekimoto M; Sano S; Hosaka T; Nemoto K; Degawa M
Biol Pharm Bull; 2012; 35(5):677-85. PubMed ID: 22687401
[TBL] [Abstract][Full Text] [Related]
20. Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.
Li L; Hassan HE; Tolson AH; Ferguson SS; Eddington ND; Wang H
J Pharmacol Exp Ther; 2010 Dec; 335(3):562-71. PubMed ID: 20829393
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]