222 related articles for article (PubMed ID: 20833873)
21. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
22. Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
Boddapati S; Levites Y; Sierks MR
J Mol Biol; 2011 Jan; 405(2):436-47. PubMed ID: 21073877
[TBL] [Abstract][Full Text] [Related]
23. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes.
Sharples RA; Vella LJ; Nisbet RM; Naylor R; Perez K; Barnham KJ; Masters CL; Hill AF
FASEB J; 2008 May; 22(5):1469-78. PubMed ID: 18171695
[TBL] [Abstract][Full Text] [Related]
24. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
25. Measuring APP carboxy-terminal fragments.
Esposito LA
Methods Mol Biol; 2011; 670():71-84. PubMed ID: 20967584
[TBL] [Abstract][Full Text] [Related]
26. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
Zhou S; Zhou H; Walian PJ; Jap BK
Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
[TBL] [Abstract][Full Text] [Related]
27. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
Martone RL; Zhou H; Atchison K; Comery T; Xu JZ; Huang X; Gong X; Jin M; Kreft A; Harrison B; Mayer SC; Aschmies S; Gonzales C; Zaleska MM; Riddell DR; Wagner E; Lu P; Sun SC; Sonnenberg-Reines J; Oganesian A; Adkins K; Leach MW; Clarke DW; Huryn D; Abou-Gharbia M; Magolda R; Bard J; Frick G; Raje S; Forlow SB; Balliet C; Burczynski ME; Reinhart PH; Wan HI; Pangalos MN; Jacobsen JS
J Pharmacol Exp Ther; 2009 Nov; 331(2):598-608. PubMed ID: 19671883
[TBL] [Abstract][Full Text] [Related]
28. The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.
Laudon H; Winblad B; Näslund J
Physiol Behav; 2007 Sep; 92(1-2):115-20. PubMed ID: 17588625
[TBL] [Abstract][Full Text] [Related]
29. Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Brijbassi S; Amtul Z; Newbigging S; Westaway D; St George-Hyslop P; Rozmahel RF
Neurobiol Dis; 2007 Feb; 25(2):291-6. PubMed ID: 17071095
[TBL] [Abstract][Full Text] [Related]
30. Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.
Shimazawa M; Inokuchi Y; Okuno T; Nakajima Y; Sakaguchi G; Kato A; Oku H; Sugiyama T; Kudo T; Ikeda T; Takeda M; Hara H
J Neurochem; 2008 Oct; 107(1):279-90. PubMed ID: 18691390
[TBL] [Abstract][Full Text] [Related]
31. PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.
Shiraishi H; Sai X; Wang HQ; Maeda Y; Kurono Y; Nishimura M; Yanagisawa K; Komano H
J Neurochem; 2004 Sep; 90(6):1402-13. PubMed ID: 15341524
[TBL] [Abstract][Full Text] [Related]
32. Presenilin dependence of phospholipase C and protein kinase C signaling.
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlström H; Benedikz E; Cowburn RF
J Neurochem; 2007 Aug; 102(3):848-57. PubMed ID: 17437536
[TBL] [Abstract][Full Text] [Related]
33. Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments.
Cagnin M; Ozzano M; Bellio N; Fiorentino I; Follo C; Isidoro C
Brain Res; 2012 Aug; 1471():102-17. PubMed ID: 22771396
[TBL] [Abstract][Full Text] [Related]
34. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Réchards M; Xia W; Oorschot V; van Dijk S; Annaert W; Selkoe DJ; Klumperman J
Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
[TBL] [Abstract][Full Text] [Related]
35. In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.
Hoke DE; Tan JL; Ilaya NT; Culvenor JG; Smith SJ; White AR; Masters CL; Evin GM
FEBS J; 2005 Nov; 272(21):5544-57. PubMed ID: 16262694
[TBL] [Abstract][Full Text] [Related]
36. Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.
Vingtdeux V; Hamdane M; Bégard S; Loyens A; Delacourte A; Beauvillain JC; Buée L; Marambaud P; Sergeant N
Neurobiol Dis; 2007 Mar; 25(3):686-96. PubMed ID: 17207630
[TBL] [Abstract][Full Text] [Related]
37. Mitochondrial amyloid-beta levels are associated with the extent of mitochondrial dysfunction in different brain regions and the degree of cognitive impairment in Alzheimer's transgenic mice.
Dragicevic N; Mamcarz M; Zhu Y; Buzzeo R; Tan J; Arendash GW; Bradshaw PC
J Alzheimers Dis; 2010; 20 Suppl 2():S535-50. PubMed ID: 20463404
[TBL] [Abstract][Full Text] [Related]
38. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
Cater MA; McInnes KT; Li QX; Volitakis I; La Fontaine S; Mercer JF; Bush AI
Biochem J; 2008 May; 412(1):141-52. PubMed ID: 18248325
[TBL] [Abstract][Full Text] [Related]
39. Intracellular domain generation of amyloid precursor protein by epsilon-cleavage depends on C-terminal fragment by alpha-secretase cleavage.
Kume H; Maruyama K; Kametani F
Int J Mol Med; 2004 Jan; 13(1):121-5. PubMed ID: 14654982
[TBL] [Abstract][Full Text] [Related]
40. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
Tesco G; Ginestroni A; Hiltunen M; Kim M; Dolios G; Hyman BT; Wang R; Berezovska O; Tanzi RE
J Neurochem; 2005 Oct; 95(2):446-56. PubMed ID: 16086682
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
