278 related articles for article (PubMed ID: 20837708)
1. Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.
Kim HW; Ha SH; Lee MN; Huston E; Kim DH; Jang SK; Suh PG; Houslay MD; Ryu SH
Mol Cell Biol; 2010 Nov; 30(22):5406-20. PubMed ID: 20837708
[TBL] [Abstract][Full Text] [Related]
2. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.
Xie J; Ponuwei GA; Moore CE; Willars GB; Tee AR; Herbert TP
Cell Signal; 2011 Dec; 23(12):1927-35. PubMed ID: 21763421
[TBL] [Abstract][Full Text] [Related]
3. Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.
Lee MN; Ha SH; Kim J; Koh A; Lee CS; Kim JH; Jeon H; Kim DH; Suh PG; Ryu SH
Mol Cell Biol; 2009 Jul; 29(14):3991-4001. PubMed ID: 19451232
[TBL] [Abstract][Full Text] [Related]
4. PDK4 protein promotes tumorigenesis through activation of cAMP-response element-binding protein (CREB)-Ras homolog enriched in brain (RHEB)-mTORC1 signaling cascade.
Liu Z; Chen X; Wang Y; Peng H; Wang Y; Jing Y; Zhang H
J Biol Chem; 2014 Oct; 289(43):29739-49. PubMed ID: 25164809
[TBL] [Abstract][Full Text] [Related]
5. Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
Sato T; Nakashima A; Guo L; Tamanoi F
J Biol Chem; 2009 May; 284(19):12783-91. PubMed ID: 19299511
[TBL] [Abstract][Full Text] [Related]
6. Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.
Yoshida S; Hong S; Suzuki T; Nada S; Mannan AM; Wang J; Okada M; Guan KL; Inoki K
J Biol Chem; 2011 Sep; 286(37):32651-60. PubMed ID: 21784859
[TBL] [Abstract][Full Text] [Related]
7. Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.
Wang X; Fonseca BD; Tang H; Liu R; Elia A; Clemens MJ; Bommer UA; Proud CG
J Biol Chem; 2008 Nov; 283(45):30482-92. PubMed ID: 18676370
[TBL] [Abstract][Full Text] [Related]
8. Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.
Groenewoud MJ; Goorden SM; Kassies J; Pellis-van Berkel W; Lamb RF; Elgersma Y; Zwartkruis FJ
PLoS One; 2013; 8(11):e81649. PubMed ID: 24303063
[TBL] [Abstract][Full Text] [Related]
9. Amino acid regulation of TOR complex 1.
Avruch J; Long X; Ortiz-Vega S; Rapley J; Papageorgiou A; Dai N
Am J Physiol Endocrinol Metab; 2009 Apr; 296(4):E592-602. PubMed ID: 18765678
[TBL] [Abstract][Full Text] [Related]
10. Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.
Jiang L; Xu L; Mao J; Li J; Fang L; Zhou Y; Liu W; He W; Zhao AZ; Yang J; Dai C
J Am Soc Nephrol; 2013 Jun; 24(7):1114-26. PubMed ID: 23661807
[TBL] [Abstract][Full Text] [Related]
11. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1.
Zheng M; Wang YH; Wu XN; Wu SQ; Lu BJ; Dong MQ; Zhang H; Sun P; Lin SC; Guan KL; Han J
Nat Cell Biol; 2011 Mar; 13(3):263-72. PubMed ID: 21336308
[TBL] [Abstract][Full Text] [Related]
12. Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.
Karassek S; Berghaus C; Schwarten M; Goemans CG; Ohse N; Kock G; Jockers K; Neumann S; Gottfried S; Herrmann C; Heumann R; Stoll R
J Biol Chem; 2010 Oct; 285(44):33979-91. PubMed ID: 20685651
[TBL] [Abstract][Full Text] [Related]
13. Lovastatin induces VSMC differentiation through inhibition of Rheb and mTOR.
Wagner RJ; Martin KA; Powell RJ; Rzucidlo EM
Am J Physiol Cell Physiol; 2010 Jul; 299(1):C119-27. PubMed ID: 20375271
[TBL] [Abstract][Full Text] [Related]
14. Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
Mazhab-Jafari MT; Marshall CB; Ho J; Ishiyama N; Stambolic V; Ikura M
J Biol Chem; 2014 May; 289(18):12195-201. PubMed ID: 24648513
[TBL] [Abstract][Full Text] [Related]
15. Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
Sato T; Akasu H; Shimono W; Matsu C; Fujiwara Y; Shibagaki Y; Heard JJ; Tamanoi F; Hattori S
J Biol Chem; 2015 Jan; 290(2):1096-105. PubMed ID: 25422319
[TBL] [Abstract][Full Text] [Related]
16. Tumorigenic activity and therapeutic inhibition of Rheb GTPase.
Mavrakis KJ; Zhu H; Silva RL; Mills JR; Teruya-Feldstein J; Lowe SW; Tam W; Pelletier J; Wendel HG
Genes Dev; 2008 Aug; 22(16):2178-88. PubMed ID: 18708578
[TBL] [Abstract][Full Text] [Related]
17. Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
Sato T; Umetsu A; Tamanoi F
Methods Enzymol; 2008; 438():307-20. PubMed ID: 18413257
[TBL] [Abstract][Full Text] [Related]
18. Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.
Ou X; Liu M; Luo H; Dong LQ; Liu F
PLoS One; 2014; 9(4):e95393. PubMed ID: 24740400
[TBL] [Abstract][Full Text] [Related]
19. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Lu ZH; Shvartsman MB; Lee AY; Shao JM; Murray MM; Kladney RD; Fan D; Krajewski S; Chiang GG; Mills GB; Arbeit JM
Cancer Res; 2010 Apr; 70(8):3287-98. PubMed ID: 20388784
[TBL] [Abstract][Full Text] [Related]
20. mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging.
Yadav RB; Burgos P; Parker AW; Iadevaia V; Proud CG; Allen RA; O'Connell JP; Jeshtadi A; Stubbs CD; Botchway SW
BMC Cell Biol; 2013 Jan; 14():3. PubMed ID: 23311891
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
