BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

333 related articles for article (PubMed ID: 20840591)

  • 1. Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
    Flashman E; Hoffart LM; Hamed RB; Bollinger JM; Krebs C; Schofield CJ
    FEBS J; 2010 Oct; 277(19):4089-99. PubMed ID: 20840591
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.
    Koivunen P; Hirsilä M; Günzler V; Kivirikko KI; Myllyharju J
    J Biol Chem; 2004 Mar; 279(11):9899-904. PubMed ID: 14701857
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
    Chowdhury R; McDonough MA; Mecinović J; Loenarz C; Flashman E; Hewitson KS; Domene C; Schofield CJ
    Structure; 2009 Jul; 17(7):981-9. PubMed ID: 19604478
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity.
    Tiainen P; Myllyharju J; Koivunen P
    J Biol Chem; 2005 Jan; 280(2):1142-8. PubMed ID: 15528200
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.
    Pappalardi MB; McNulty DE; Martin JD; Fisher KE; Jiang Y; Burns MC; Zhao H; Ho T; Sweitzer S; Schwartz B; Annan RS; Copeland RA; Tummino PJ; Luo L
    Biochem J; 2011 Jun; 436(2):363-9. PubMed ID: 21410436
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
    Chowdhury R; Flashman E; Mecinović J; Kramer HB; Kessler BM; Frapart YM; Boucher JL; Clifton IJ; McDonough MA; Schofield CJ
    J Mol Biol; 2011 Jul; 410(2):268-79. PubMed ID: 21601578
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents.
    Flashman E; Davies SL; Yeoh KK; Schofield CJ
    Biochem J; 2010 Mar; 427(1):135-42. PubMed ID: 20055761
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.
    Flashman E; Bagg EA; Chowdhury R; Mecinović J; Loenarz C; McDonough MA; Hewitson KS; Schofield CJ
    J Biol Chem; 2008 Feb; 283(7):3808-15. PubMed ID: 18063574
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2.
    Figg WD; Fiorini G; Chowdhury R; Nakashima Y; Tumber A; McDonough MA; Schofield CJ
    Proteins; 2023 Nov; 91(11):1510-1524. PubMed ID: 37449559
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.
    Abboud MI; McAllister TE; Leung IKH; Chowdhury R; Jorgensen C; Domene C; Mecinović J; Lippl K; Hancock RL; Hopkinson RJ; Kawamura A; Claridge TDW; Schofield CJ
    Chem Commun (Camb); 2018 Mar; 54(25):3130-3133. PubMed ID: 29522057
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from
    Liu T; Abboud MI; Chowdhury R; Tumber A; Hardy AP; Lippl K; Lohans CT; Pires E; Wickens J; McDonough MA; West CM; Schofield CJ
    J Biol Chem; 2020 Dec; 295(49):16545-16561. PubMed ID: 32934009
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
    Tuckerman JR; Zhao Y; Hewitson KS; Tian YM; Pugh CW; Ratcliffe PJ; Mole DR
    FEBS Lett; 2004 Oct; 576(1-2):145-50. PubMed ID: 15474027
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay.
    Ehrismann D; Flashman E; Genn DN; Mathioudakis N; Hewitson KS; Ratcliffe PJ; Schofield CJ
    Biochem J; 2007 Jan; 401(1):227-34. PubMed ID: 16952279
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The use of dioxygen by HIF prolyl hydroxylase (PHD1).
    McNeill LA; Hewitson KS; Gleadle JM; Horsfall LE; Oldham NJ; Maxwell PH; Pugh CW; Ratcliffe PJ; Schofield CJ
    Bioorg Med Chem Lett; 2002 Jun; 12(12):1547-50. PubMed ID: 12039559
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Studies on the Substrate Selectivity of the Hypoxia-Inducible Factor Prolyl Hydroxylase 2 Catalytic Domain.
    Abboud MI; Chowdhury R; Leung IKH; Lippl K; Loenarz C; Claridge TDW; Schofield CJ
    Chembiochem; 2018 Nov; 19(21):2262-2267. PubMed ID: 30144273
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].
    Stolze IP; Tian YM; Appelhoff RJ; Turley H; Wykoff CC; Gleadle JM; Ratcliffe PJ
    J Biol Chem; 2004 Oct; 279(41):42719-25. PubMed ID: 15302861
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.
    Pappalardi MB; Martin JD; Jiang Y; Burns MC; Zhao H; Ho T; Sweitzer S; Lor L; Schwartz B; Duffy K; Gontarek R; Tummino PJ; Copeland RA; Luo L
    Biochemistry; 2008 Oct; 47(43):11165-7. PubMed ID: 18834144
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of a region on hypoxia-inducible-factor prolyl 4-hydroxylases that determines their specificity for the oxygen degradation domains.
    Villar D; Vara-Vega A; Landázuri MO; Del Peso L
    Biochem J; 2007 Dec; 408(2):231-40. PubMed ID: 17725546
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.
    D'Angelo G; Duplan E; Boyer N; Vigne P; Frelin C
    J Biol Chem; 2003 Oct; 278(40):38183-7. PubMed ID: 12876291
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Determination and modulation of prolyl-4-hydroxylase domain oxygen sensor activity.
    Wirthner R; Balamurugan K; Stiehl DP; Barth S; Spielmann P; Oehme F; Flamme I; Katschinski DM; Wenger RH; Camenisch G
    Methods Enzymol; 2007; 435():43-60. PubMed ID: 17998048
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 17.