448 related articles for article (PubMed ID: 20849150)
1. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
Dragovic S; Boerma JS; van Bergen L; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2010 Sep; 23(9):1467-76. PubMed ID: 20849150
[TBL] [Abstract][Full Text] [Related]
2. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.
Dragovic S; Venkataraman H; Begheijn S; Vermeulen NP; Commandeur JN
Toxicol Lett; 2014 Jan; 224(2):272-81. PubMed ID: 24185126
[TBL] [Abstract][Full Text] [Related]
3. Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.
Vredenburg G; Vassell KP; Commandeur JN; Vermeulen NP; Vos JC
Toxicol Lett; 2013 Oct; 222(3):247-56. PubMed ID: 23916688
[TBL] [Abstract][Full Text] [Related]
4. Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates.
Rea V; Dragovic S; Boerma JS; de Kanter FJ; Vermeulen NP; Commandeur JN
Drug Metab Dispos; 2011 Dec; 39(12):2411-20. PubMed ID: 21890734
[TBL] [Abstract][Full Text] [Related]
5. Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.
Dragovic S; Boerma JS; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2013 Nov; 26(11):1632-41. PubMed ID: 24083800
[TBL] [Abstract][Full Text] [Related]
6. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
Boerma JS; Vermeulen NP; Commandeur JN
Chem Biol Interact; 2014 Jan; 207():32-40. PubMed ID: 24246759
[TBL] [Abstract][Full Text] [Related]
7. Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
Boerma JS; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2011 Aug; 24(8):1263-74. PubMed ID: 21639118
[TBL] [Abstract][Full Text] [Related]
8. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives.
Fujioka K; Casida JE
Chem Res Toxicol; 2007 Aug; 20(8):1211-7. PubMed ID: 17645302
[TBL] [Abstract][Full Text] [Related]
9. Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.
Boerma JS; Dragovic S; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2012 Nov; 25(11):2532-41. PubMed ID: 22998212
[TBL] [Abstract][Full Text] [Related]
10. Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.
Venkataraman H; den Braver MW; Vermeulen NP; Commandeur JN
Chem Res Toxicol; 2014 Dec; 27(12):2071-81. PubMed ID: 25372302
[TBL] [Abstract][Full Text] [Related]
11. Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione.
Dirven HA; van Ommen B; van Bladeren PJ
Cancer Res; 1994 Dec; 54(23):6215-20. PubMed ID: 7954469
[TBL] [Abstract][Full Text] [Related]
12. Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.
Damsten MC; van Vugt-Lussenburg BM; Zeldenthuis T; de Vlieger JS; Commandeur JN; Vermeulen NP
Chem Biol Interact; 2008 Jan; 171(1):96-107. PubMed ID: 17996858
[TBL] [Abstract][Full Text] [Related]
13. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man.
Maggs JL; Williams D; Pirmohamed M; Park BK
J Pharmacol Exp Ther; 1995 Dec; 275(3):1463-75. PubMed ID: 8531117
[TBL] [Abstract][Full Text] [Related]
14. The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.
Dirven HA; Dictus EL; Broeders NL; van Ommen B; van Bladeren PJ
Cancer Res; 1995 Apr; 55(8):1701-6. PubMed ID: 7712478
[TBL] [Abstract][Full Text] [Related]
15. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
Hissink AM; Oudshoorn MJ; Van Ommen B; Haenen GR; Van Bladeren PJ
Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
[TBL] [Abstract][Full Text] [Related]
16. Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in rabbit lung and liver.
Stewart RK; Serabjit-Singh CJ; Massey TE
Toxicol Appl Pharmacol; 1996 Oct; 140(2):499-507. PubMed ID: 8887467
[TBL] [Abstract][Full Text] [Related]
17. Glutathione transferase theta 1-1-dependent metabolism of the water disinfection byproduct bromodichloromethane.
Ross MK; Pegram RA
Chem Res Toxicol; 2003 Feb; 16(2):216-26. PubMed ID: 12588193
[TBL] [Abstract][Full Text] [Related]
18. Glutathione S-transferase enzyme expression in hematopoietic cell lines implies a differential protective role for T1 and A1 isoenzymes in erythroid and for M1 in lymphoid lineages.
Wang L; Groves MJ; Hepburn MD; Bowen DT
Haematologica; 2000 Jun; 85(6):573-9. PubMed ID: 10870112
[TBL] [Abstract][Full Text] [Related]
19. In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
Ross MK; Pegram RA
Toxicol Appl Pharmacol; 2004 Mar; 195(2):166-81. PubMed ID: 14998683
[TBL] [Abstract][Full Text] [Related]
20. Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: possible role in agranulocytosis.
Williams DP; Pirmohamed M; Naisbitt DJ; Maggs JL; Park BK
J Pharmacol Exp Ther; 1997 Dec; 283(3):1375-82. PubMed ID: 9400013
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
