206 related articles for article (PubMed ID: 20850300)
1. Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
Scheiper B; Matter H; Steinhagen H; Stilz U; Böcskei Z; Fleury V; McCort G
Bioorg Med Chem Lett; 2010 Nov; 20(21):6268-72. PubMed ID: 20850300
[TBL] [Abstract][Full Text] [Related]
2. Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
Scheiper B; Matter H; Steinhagen H; Böcskei Z; Fleury V; McCort G
Bioorg Med Chem Lett; 2011 Sep; 21(18):5480-6. PubMed ID: 21840218
[TBL] [Abstract][Full Text] [Related]
3. Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
Matter H; Scheiper B; Steinhagen H; Böcskei Z; Fleury V; McCort G
Bioorg Med Chem Lett; 2011 Sep; 21(18):5487-92. PubMed ID: 21840215
[TBL] [Abstract][Full Text] [Related]
4. Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Bezençon O; Bur D; Weller T; Richard-Bildstein S; Remen L; Sifferlen T; Corminboeuf O; Grisostomi C; Boss C; Prade L; Delahaye S; Treiber A; Strickner P; Binkert C; Hess P; Steiner B; Fischli W
J Med Chem; 2009 Jun; 52(12):3689-702. PubMed ID: 19358611
[TBL] [Abstract][Full Text] [Related]
5. Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors.
Holsworth DD; Jalaie M; Belliotti T; Cai C; Collard W; Ferreira S; Powell NA; Stier M; Zhang E; McConnell P; Mochalkin I; Ryan MJ; Bryant J; Li T; Kasani A; Subedi R; Maiti SN; Edmunds JJ
Bioorg Med Chem Lett; 2007 Jul; 17(13):3575-80. PubMed ID: 17482464
[TBL] [Abstract][Full Text] [Related]
6. Indole RSK inhibitors. Part 1: discovery and initial SAR.
Boyer SJ; Burke J; Guo X; Kirrane TM; Snow RJ; Zhang Y; Sarko C; Soleymanzadeh L; Swinamer A; Westbrook J; Dicapua F; Padyana A; Cogan D; Gao A; Xiong Z; Madwed JB; Kashem M; Kugler S; O'Neill MM
Bioorg Med Chem Lett; 2012 Jan; 22(1):733-7. PubMed ID: 22100312
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and SAR studies of indole-based MK2 inhibitors.
Xiong Z; Gao DA; Cogan DA; Goldberg DR; Hao MH; Moss N; Pack E; Pargellis C; Skow D; Trieselmann T; Werneburg B; White A
Bioorg Med Chem Lett; 2008 Mar; 18(6):1994-9. PubMed ID: 18291646
[TBL] [Abstract][Full Text] [Related]
8. Indole RSK inhibitors. Part 2: optimization of cell potency and kinase selectivity.
Kirrane TM; Boyer SJ; Burke J; Guo X; Snow RJ; Soleymanzadeh L; Swinamer A; Zhang Y; Madwed JB; Kashem M; Kugler S; O'Neill MM
Bioorg Med Chem Lett; 2012 Jan; 22(1):738-42. PubMed ID: 22056746
[TBL] [Abstract][Full Text] [Related]
9. Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors.
Dublanchet AC; Ducrot P; Andrianjara C; O'Gara M; Morales R; Compère D; Denis A; Blais S; Cluzeau P; Courté K; Hamon J; Moreau F; Prunet ML; Tertre A
Bioorg Med Chem Lett; 2005 Aug; 15(16):3787-90. PubMed ID: 16002291
[TBL] [Abstract][Full Text] [Related]
10. Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists.
Lippa B; Morris J; Corbett M; Kwan TA; Noe MC; Snow SL; Gant TG; Mangiaracina M; Coffey HA; Foster B; Knauth EA; Wessel MD
Bioorg Med Chem Lett; 2006 Jul; 16(13):3444-8. PubMed ID: 16632359
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.
Onda K; Shiraki R; Ogiyama T; Yokoyama K; Momose K; Katayama N; Orita M; Yamaguchi T; Furutani M; Hamada N; Takeuchi M; Okada M; Ohta M; Tsukamoto S
Bioorg Med Chem; 2008 Dec; 16(23):10001-12. PubMed ID: 18952447
[TBL] [Abstract][Full Text] [Related]
12. Design and optimization of new piperidines as renin inhibitors.
Corminboeuf O; Bezençon O; Grisostomi C; Remeň L; Richard-Bildstein S; Bur D; Prade L; Hess P; Strickner P; Fischli W; Steiner B; Treiber A
Bioorg Med Chem Lett; 2010 Nov; 20(21):6286-90. PubMed ID: 20843686
[TBL] [Abstract][Full Text] [Related]
13. Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.
Nishiguchi GA; Atallah G; Bellamacina C; Burger MT; Ding Y; Feucht PH; Garcia PD; Han W; Klivansky L; Lindvall M
Bioorg Med Chem Lett; 2011 Nov; 21(21):6366-9. PubMed ID: 21945284
[TBL] [Abstract][Full Text] [Related]
14. Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.
Mori Y; Ogawa Y; Mochizuki A; Nakamura Y; Sugita C; Miyazaki S; Tamaki K; Matsui Y; Takahashi M; Nagayama T; Nagai Y; Inoue S; Nishi T
Bioorg Med Chem Lett; 2012 Dec; 22(24):7677-82. PubMed ID: 23122821
[TBL] [Abstract][Full Text] [Related]
15. Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
Chowdhury S; Sessions EH; Pocas JR; Grant W; Schröter T; Lin L; Ruiz C; Cameron MD; Schürer S; LoGrasso P; Bannister TD; Feng Y
Bioorg Med Chem Lett; 2011 Dec; 21(23):7107-12. PubMed ID: 22004718
[TBL] [Abstract][Full Text] [Related]
16. Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.
Chen A; Bayly C; Bezençon O; Richard-Bildstein S; Dubé D; Dubé L; Gagné S; Gallant M; Gaudreault M; Grimm E; Houle R; Lacombe P; Laliberté S; Lévesque JF; Liu S; MacDonald D; Mackay B; Martin D; McKay D; Powell D; Remen L; Soisson S; Toulmond S
Bioorg Med Chem Lett; 2010 Apr; 20(7):2204-9. PubMed ID: 20206513
[TBL] [Abstract][Full Text] [Related]
17. Optimization of orally bioavailable alkyl amine renin inhibitors.
Xu Z; Cacatian S; Yuan J; Simpson RD; Jia L; Zhao W; Tice CM; Flaherty PT; Guo J; Ishchenko A; Singh SB; Wu Z; McKeever BM; Scott BB; Bukhtiyarov Y; Berbaum J; Mason J; Panemangalore R; Cappiello MG; Bentley R; Doe CP; Harrison RK; McGeehan GM; Dillard LW; Baldwin JJ; Claremon DA
Bioorg Med Chem Lett; 2010 Jan; 20(2):694-9. PubMed ID: 19959358
[TBL] [Abstract][Full Text] [Related]
18. Identification of novel p38alpha MAP kinase inhibitors using fragment-based lead generation.
Gill AL; Frederickson M; Cleasby A; Woodhead SJ; Carr MG; Woodhead AJ; Walker MT; Congreve MS; Devine LA; Tisi D; O'Reilly M; Seavers LC; Davis DJ; Curry J; Anthony R; Padova A; Murray CW; Carr RA; Jhoti H
J Med Chem; 2005 Jan; 48(2):414-26. PubMed ID: 15658855
[TBL] [Abstract][Full Text] [Related]
19. Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.
Yi Mok N; Chadwick J; Kellett KA; Hooper NM; Johnson AP; Fishwick CW
Bioorg Med Chem Lett; 2009 Dec; 19(23):6770-4. PubMed ID: 19854048
[TBL] [Abstract][Full Text] [Related]
20. Discovery and optimization of antibacterial AccC inhibitors.
Cheng CC; Shipps GW; Yang Z; Sun B; Kawahata N; Soucy KA; Soriano A; Orth P; Xiao L; Mann P; Black T
Bioorg Med Chem Lett; 2009 Dec; 19(23):6507-14. PubMed ID: 19875284
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]