314 related articles for article (PubMed ID: 20855463)
1. The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.
Xiao Y; Blumenthal K; Jackson JO; Liang S; Cummins TR
Mol Pharmacol; 2010 Dec; 78(6):1124-34. PubMed ID: 20855463
[TBL] [Abstract][Full Text] [Related]
2. Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.
Xiao Y; Blumenthal K; Cummins TR
Mol Pharmacol; 2014 Aug; 86(2):159-67. PubMed ID: 24898004
[TBL] [Abstract][Full Text] [Related]
3. Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.
Xiao Y; Jackson JO; Liang S; Cummins TR
J Biol Chem; 2011 Aug; 286(31):27301-10. PubMed ID: 21659528
[TBL] [Abstract][Full Text] [Related]
4. Two tarantula peptides inhibit activation of multiple sodium channels.
Middleton RE; Warren VA; Kraus RL; Hwang JC; Liu CJ; Dai G; Brochu RM; Kohler MG; Gao YD; Garsky VM; Bogusky MJ; Mehl JT; Cohen CJ; Smith MM
Biochemistry; 2002 Dec; 41(50):14734-47. PubMed ID: 12475222
[TBL] [Abstract][Full Text] [Related]
5. Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.
Xiao Y; Bingham JP; Zhu W; Moczydlowski E; Liang S; Cummins TR
J Biol Chem; 2008 Oct; 283(40):27300-13. PubMed ID: 18628201
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of sodium channel gating by trapping the domain II voltage sensor with protoxin II.
Sokolov S; Kraus RL; Scheuer T; Catterall WA
Mol Pharmacol; 2008 Mar; 73(3):1020-8. PubMed ID: 18156314
[TBL] [Abstract][Full Text] [Related]
7. ProTx-I and ProTx-II: gating modifiers of voltage-gated sodium channels.
Priest BT; Blumenthal KM; Smith JJ; Warren VA; Smith MM
Toxicon; 2007 Feb; 49(2):194-201. PubMed ID: 17087985
[TBL] [Abstract][Full Text] [Related]
8. ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.
Schmalhofer WA; Calhoun J; Burrows R; Bailey T; Kohler MG; Weinglass AB; Kaczorowski GJ; Garcia ML; Koltzenburg M; Priest BT
Mol Pharmacol; 2008 Nov; 74(5):1476-84. PubMed ID: 18728100
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor.
Deng M; Luo X; Jiang L; Chen H; Wang J; He H; Liang S
Toxicon; 2013 Sep; 71():57-65. PubMed ID: 23726857
[TBL] [Abstract][Full Text] [Related]
10. Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.
Rong M; Duan Z; Chen J; Li J; Xiao Y; Liang S
PLoS One; 2013; 8(6):e65984. PubMed ID: 23826086
[TBL] [Abstract][Full Text] [Related]
11. Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.
Smith JJ; Cummins TR; Alphy S; Blumenthal KM
J Biol Chem; 2007 Apr; 282(17):12687-97. PubMed ID: 17339321
[TBL] [Abstract][Full Text] [Related]
12. Direct evidence for high affinity blockade of Na
Gonçalves TC; Boukaiba R; Molgó J; Amar M; Partiseti M; Servent D; Benoit E
Neuropharmacology; 2018 May; 133():404-414. PubMed ID: 29474819
[TBL] [Abstract][Full Text] [Related]
13. Potency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel Na
Katz D; Sindhikara D; DiMattia M; Leffler AE
Toxins (Basel); 2021 Mar; 13(3):. PubMed ID: 33800031
[TBL] [Abstract][Full Text] [Related]
14. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.
Agwa AJ; Tran P; Mueller A; Tran HNT; Deuis JR; Israel MR; McMahon KL; Craik DJ; Vetter I; Schroeder CI
J Biol Chem; 2020 Apr; 295(15):5067-5080. PubMed ID: 32139508
[TBL] [Abstract][Full Text] [Related]
15. Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNa
Agwa AJ; Lawrence N; Deplazes E; Cheneval O; Chen RM; Craik DJ; Schroeder CI; Henriques ST
Biochim Biophys Acta Biomembr; 2017 May; 1859(5):835-844. PubMed ID: 28115115
[TBL] [Abstract][Full Text] [Related]
16. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na
Rupasinghe DB; Herzig V; Vetter I; Dekan Z; Gilchrist J; Bosmans F; Alewood PF; Lewis RJ; King GF
Biochem Pharmacol; 2020 Nov; 181():114080. PubMed ID: 32511987
[TBL] [Abstract][Full Text] [Related]
17. Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).
Minassian NA; Gibbs A; Shih AY; Liu Y; Neff RA; Sutton SW; Mirzadegan T; Connor J; Fellows R; Husovsky M; Nelson S; Hunter MJ; Flinspach M; Wickenden AD
J Biol Chem; 2013 Aug; 288(31):22707-20. PubMed ID: 23760503
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels.
Xiao Y; Luo X; Kuang F; Deng M; Wang M; Zeng X; Liang S
Toxicon; 2008 Feb; 51(2):230-9. PubMed ID: 18054060
[TBL] [Abstract][Full Text] [Related]
19. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7.
Henriques ST; Deplazes E; Lawrence N; Cheneval O; Chaousis S; Inserra M; Thongyoo P; King GF; Mark AE; Vetter I; Craik DJ; Schroeder CI
J Biol Chem; 2016 Aug; 291(33):17049-65. PubMed ID: 27311819
[TBL] [Abstract][Full Text] [Related]
20. Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V.
Moyer BD; Murray JK; Ligutti J; Andrews K; Favreau P; Jordan JB; Lee JH; Liu D; Long J; Sham K; Shi L; Stöcklin R; Wu B; Yin R; Yu V; Zou A; Biswas K; Miranda LP
PLoS One; 2018; 13(5):e0196791. PubMed ID: 29723257
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
