273 related articles for article (PubMed ID: 20855577)
1. Defining the mechanism of polymerization in the serpinopathies.
Ekeowa UI; Freeke J; Miranda E; Gooptu B; Bush MF; Pérez J; Teckman J; Robinson CV; Lomas DA
Proc Natl Acad Sci U S A; 2010 Oct; 107(40):17146-51. PubMed ID: 20855577
[TBL] [Abstract][Full Text] [Related]
2. The serpinopathies studying serpin polymerization in vivo.
Irving JA; Ekeowa UI; Belorgey D; Haq I; Gooptu B; Miranda E; Pérez J; Roussel BD; Ordóñez A; Dalton LE; Thomas SE; Marciniak SJ; Parfrey H; Chilvers ER; Teckman JH; Alam S; Mahadeva R; Rashid ST; Vallier L; Lomas DA
Methods Enzymol; 2011; 501():421-66. PubMed ID: 22078544
[TBL] [Abstract][Full Text] [Related]
3. 6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization. Implications for the prevention of Z alpha(1)-antitrypsin-related cirrhosis.
Mahadeva R; Dafforn TR; Carrell RW; Lomas DA
J Biol Chem; 2002 Mar; 277(9):6771-4. PubMed ID: 11773044
[TBL] [Abstract][Full Text] [Related]
4. Fluorescence correlation spectroscopic study of serpin depolymerization by computationally designed peptides.
Chowdhury P; Wang W; Lavender S; Bunagan MR; Klemke JW; Tang J; Saven JG; Cooperman BS; Gai F
J Mol Biol; 2007 Jun; 369(2):462-73. PubMed ID: 17442346
[TBL] [Abstract][Full Text] [Related]
5. The structural basis of serpin polymerization studied by hydrogen/deuterium exchange and mass spectrometry.
Tsutsui Y; Kuri B; Sengupta T; Wintrode PL
J Biol Chem; 2008 Nov; 283(45):30804-11. PubMed ID: 18794298
[TBL] [Abstract][Full Text] [Related]
6. alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.
Lomas DA; Elliott PR; Sidhar SK; Foreman RC; Finch JT; Cox DW; Whisstock JC; Carrell RW
J Biol Chem; 1995 Jul; 270(28):16864-70. PubMed ID: 7622502
[TBL] [Abstract][Full Text] [Related]
7. Conformational pathology of the serpins: themes, variations, and therapeutic strategies.
Gooptu B; Lomas DA
Annu Rev Biochem; 2009; 78():147-76. PubMed ID: 19245336
[TBL] [Abstract][Full Text] [Related]
8. Dynamic local unfolding in the serpin α-1 antitrypsin provides a mechanism for loop insertion and polymerization.
Krishnan B; Gierasch LM
Nat Struct Mol Biol; 2011 Feb; 18(2):222-6. PubMed ID: 21258324
[TBL] [Abstract][Full Text] [Related]
9. Parker B. Francis lectureship. Antitrypsin deficiency, the serpinopathies, and chronic obstructive pulmonary disease.
Lomas DA
Proc Am Thorac Soc; 2006 Aug; 3(6):499-501. PubMed ID: 16921127
[TBL] [Abstract][Full Text] [Related]
10. Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis.
Sharp LK; Mallya M; Kinghorn KJ; Wang Z; Crowther DC; Huntington JA; Belorgey D; Lomas DA
FEBS J; 2006 Jun; 273(11):2540-52. PubMed ID: 16704419
[TBL] [Abstract][Full Text] [Related]
11. New insights into the structural basis of alpha 1-antitrypsin deficiency.
Lomas DA
QJM; 1996 Nov; 89(11):807-12. PubMed ID: 8977959
[TBL] [Abstract][Full Text] [Related]
12. The molecular aetiology of the serpinopathies.
Davies MJ; Lomas DA
Int J Biochem Cell Biol; 2008; 40(6-7):1273-86. PubMed ID: 18289918
[TBL] [Abstract][Full Text] [Related]
13. Conformational changes in serpins and the mechanism of alpha 1-antitrypsin deficiency.
Carrell RW; Whisstock J; Lomas DA
Am J Respir Crit Care Med; 1994 Dec; 150(6 Pt 2):S171-5. PubMed ID: 7952655
[TBL] [Abstract][Full Text] [Related]
14. Hypersensitive mousetraps, alpha1-antitrypsin deficiency and dementia.
Lomas DA; Lourbakos A; Cumming SA; Belorgey D
Biochem Soc Trans; 2002 Apr; 30(2):89-92. PubMed ID: 12023831
[TBL] [Abstract][Full Text] [Related]
15. Structural basis for serpin inhibitor activity.
Wright HT; Scarsdale JN
Proteins; 1995 Jul; 22(3):210-25. PubMed ID: 7479695
[TBL] [Abstract][Full Text] [Related]
16. Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies.
Crowther DC; Belorgey D; Miranda E; Kinghorn KJ; Sharp LK; Lomas DA
Eur J Hum Genet; 2004 Mar; 12(3):167-72. PubMed ID: 14694355
[TBL] [Abstract][Full Text] [Related]
17. Unravelling the twists and turns of the serpinopathies.
Roussel BD; Irving JA; Ekeowa UI; Belorgey D; Haq I; Ordóñez A; Kruppa AJ; Duvoix A; Rashid ST; Crowther DC; Marciniak SJ; Lomas DA
FEBS J; 2011 Oct; 278(20):3859-67. PubMed ID: 21624056
[TBL] [Abstract][Full Text] [Related]
18. Polymerisation underlies alpha1-antitrypsin deficiency, dementia and other serpinopathies.
Lomas DA; Belorgey D; Mallya M; Onda M; Kinghorn KJ; Sharp LK; Phillips RL; Page R; Crowther DC; Miranda E
Front Biosci; 2004 Sep; 9():2873-91. PubMed ID: 15353322
[TBL] [Abstract][Full Text] [Related]
19. Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.
Elliott PR; Lomas DA; Carrell RW; Abrahams JP
Nat Struct Biol; 1996 Aug; 3(8):676-81. PubMed ID: 8756325
[TBL] [Abstract][Full Text] [Related]
20. Molecular mousetraps and the serpinopathies.
Lomas DA; Belorgey D; Mallya M; Miranda E; Kinghorn KJ; Sharp LK; Phillips RL; Page R; Robertson AS; Crowther DC
Biochem Soc Trans; 2005 Apr; 33(Pt 2):321-30. PubMed ID: 15787598
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]