187 related articles for article (PubMed ID: 20864533)
1. Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle.
Lotz GP; Legleiter J; Aron R; Mitchell EJ; Huang SY; Ng C; Glabe C; Thompson LM; Muchowski PJ
J Biol Chem; 2010 Dec; 285(49):38183-93. PubMed ID: 20864533
[TBL] [Abstract][Full Text] [Related]
2. A platform to view huntingtin exon 1 aggregation flux in the cell reveals divergent influences from chaperones hsp40 and hsp70.
Ormsby AR; Ramdzan YM; Mok YF; Jovanoski KD; Hatters DM
J Biol Chem; 2013 Dec; 288(52):37192-203. PubMed ID: 24196953
[TBL] [Abstract][Full Text] [Related]
3. Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation.
Waelter S; Boeddrich A; Lurz R; Scherzinger E; Lueder G; Lehrach H; Wanker EE
Mol Biol Cell; 2001 May; 12(5):1393-407. PubMed ID: 11359930
[TBL] [Abstract][Full Text] [Related]
4. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.
Goswami A; Dikshit P; Mishra A; Mulherkar S; Nukina N; Jana NR
Biochem Biophys Res Commun; 2006 Mar; 342(1):184-90. PubMed ID: 16472774
[TBL] [Abstract][Full Text] [Related]
5. Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo.
Legleiter J; Mitchell E; Lotz GP; Sapp E; Ng C; DiFiglia M; Thompson LM; Muchowski PJ
J Biol Chem; 2010 May; 285(19):14777-90. PubMed ID: 20220138
[TBL] [Abstract][Full Text] [Related]
6. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils.
Muchowski PJ; Schaffar G; Sittler A; Wanker EE; Hayer-Hartl MK; Hartl FU
Proc Natl Acad Sci U S A; 2000 Jul; 97(14):7841-6. PubMed ID: 10859365
[TBL] [Abstract][Full Text] [Related]
7. Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.
Wacker JL; Zareie MH; Fong H; Sarikaya M; Muchowski PJ
Nat Struct Mol Biol; 2004 Dec; 11(12):1215-22. PubMed ID: 15543156
[TBL] [Abstract][Full Text] [Related]
8. Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease.
Wyttenbach A; Swartz J; Kita H; Thykjaer T; Carmichael J; Bradley J; Brown R; Maxwell M; Schapira A; Orntoft TF; Kato K; Rubinsztein DC
Hum Mol Genet; 2001 Aug; 10(17):1829-45. PubMed ID: 11532992
[TBL] [Abstract][Full Text] [Related]
9. Using bicistronic constructs to evaluate the chaperone activities of heat shock proteins in cells.
San Gil R; Berg T; Ecroyd H
Sci Rep; 2017 May; 7(1):2387. PubMed ID: 28539657
[TBL] [Abstract][Full Text] [Related]
10. Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity.
Jana NR; Tanaka M; Wang Gh; Nukina N
Hum Mol Genet; 2000 Aug; 9(13):2009-18. PubMed ID: 10942430
[TBL] [Abstract][Full Text] [Related]
11. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.
Orr AL; Huang S; Roberts MA; Reed JC; Li S; Li XJ
J Biol Chem; 2008 Jun; 283(23):16027-36. PubMed ID: 18400759
[TBL] [Abstract][Full Text] [Related]
12. Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment.
Zala D; Benchoua A; Brouillet E; Perrin V; Gaillard MC; Zurn AD; Aebischer P; Déglon N
Neurobiol Dis; 2005 Dec; 20(3):785-98. PubMed ID: 16006135
[TBL] [Abstract][Full Text] [Related]
13. Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation.
Zhou H; Li SH; Li XJ
J Biol Chem; 2001 Dec; 276(51):48417-24. PubMed ID: 11606565
[TBL] [Abstract][Full Text] [Related]
14. Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones.
Hinault MP; Cuendet AF; Mattoo RU; Mensi M; Dietler G; Lashuel HA; Goloubinoff P
J Biol Chem; 2010 Dec; 285(49):38173-82. PubMed ID: 20847048
[TBL] [Abstract][Full Text] [Related]
15. Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease.
Sittler A; Lurz R; Lueder G; Priller J; Lehrach H; Hayer-Hartl MK; Hartl FU; Wanker EE
Hum Mol Genet; 2001 Jun; 10(12):1307-15. PubMed ID: 11406612
[TBL] [Abstract][Full Text] [Related]
16. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation.
Rampelt H; Kirstein-Miles J; Nillegoda NB; Chi K; Scholz SR; Morimoto RI; Bukau B
EMBO J; 2012 Nov; 31(21):4221-35. PubMed ID: 22990239
[TBL] [Abstract][Full Text] [Related]
17. The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant huntingtin among neuronal subtypes.
Tagawa K; Marubuchi S; Qi ML; Enokido Y; Tamura T; Inagaki R; Murata M; Kanazawa I; Wanker EE; Okazawa H
J Neurosci; 2007 Jan; 27(4):868-80. PubMed ID: 17251428
[TBL] [Abstract][Full Text] [Related]
18. Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction.
Chen JY; Parekh M; Seliman H; Bakshinskaya D; Dai W; Kwan K; Chen KY; Liu AYC
J Biol Chem; 2018 Oct; 293(40):15581-15593. PubMed ID: 30143534
[TBL] [Abstract][Full Text] [Related]
19. Inducing huntingtin inclusion formation in primary neuronal cell culture and in vivo by high-capacity adenoviral vectors expressing truncated and full-length huntingtin with polyglutamine expansion.
Huang B; Schiefer J; Sass C; Kosinski CM; Kochanek S
J Gene Med; 2008 Mar; 10(3):269-79. PubMed ID: 18067195
[TBL] [Abstract][Full Text] [Related]
20. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
Orr AL; Li S; Wang CE; Li H; Wang J; Rong J; Xu X; Mastroberardino PG; Greenamyre JT; Li XJ
J Neurosci; 2008 Mar; 28(11):2783-92. PubMed ID: 18337408
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
