BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 20873775)

  • 1. Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists.
    Frølund S; Bella A; Kristensen AS; Ziegler HL; Witt M; Olsen CA; Strømgaard K; Franzyk H; Jaroszewski JW
    J Med Chem; 2010 Oct; 53(20):7441-51. PubMed ID: 20873775
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
    Kromann H; Krikstolaityte S; Andersen AJ; Andersen K; Krogsgaard-Larsen P; Jaroszewski JW; Egebjerg J; Strømgaard K
    J Med Chem; 2002 Dec; 45(26):5745-54. PubMed ID: 12477358
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors.
    Nelson JK; Frølund SU; Tikhonov DB; Kristensen AS; Strømgaard K
    Angew Chem Int Ed Engl; 2009; 48(17):3087-91. PubMed ID: 19152392
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.
    Strømgaard K; Brier TJ; Andersen K; Mellor IR; Saghyan A; Tikhonov D; Usherwood PN; Krogsgaard-Larsen P; Jaroszewski JW
    J Med Chem; 2000 Nov; 43(23):4526-33. PubMed ID: 11087577
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The effects of conformational constraints and steric bulk in the amino acid moiety of philanthotoxins on AMPAR antagonism.
    Jørgensen MR; Olsen CA; Mellor IR; Usherwood PN; Witt M; Franzyk H; Jaroszewski JW
    J Med Chem; 2005 Jan; 48(1):56-70. PubMed ID: 15634001
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins.
    Brackley PT; Bell DR; Choi SK; Nakanishi K; Usherwood PN
    J Pharmacol Exp Ther; 1993 Sep; 266(3):1573-80. PubMed ID: 7690404
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.
    Lolli ML; Giordano C; Pickering DS; Rolando B; Hansen KB; Foti A; Contreras-Sanz A; Amir A; Fruttero R; Gasco A; Nielsen B; Johansen TN
    J Med Chem; 2010 May; 53(10):4110-8. PubMed ID: 20408529
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives.
    Andersen TF; Tikhonov DB; Bølcho U; Bolshakov K; Nelson JK; Pluteanu F; Mellor IR; Egebjerg J; Strømgaard K
    J Med Chem; 2006 Sep; 49(18):5414-23. PubMed ID: 16942015
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Neuroprotection by tosyl-polyamine derivatives through the inhibition of ionotropic glutamate receptors.
    Masuko T; Namiki R; Nemoto Y; Miyake M; Kizawa Y; Suzuki T; Kashiwagi K; Igarashi K; Kusama T
    J Pharmacol Exp Ther; 2009 Nov; 331(2):522-30. PubMed ID: 19644042
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Anthraquinone polyamines: novel channel blockers to study N-methyl-D-aspartate receptors.
    Kashiwagi K; Tanaka I; Tamura M; Sugiyama H; Okawara T; Otsuka M; Sabado TN; Williams K; Igarashi K
    J Pharmacol Exp Ther; 2004 Jun; 309(3):884-93. PubMed ID: 14764657
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors.
    Mellor IR; Brier TJ; Pluteanu F; Strømgaard K; Saghyan A; Eldursi N; Brierley MJ; Andersen K; Jaroszewski JW; Krogsgaard-Larsen P; Usherwood PN
    Neuropharmacology; 2003 Jan; 44(1):70-80. PubMed ID: 12559123
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors.
    Nørager NG; Poulsen MH; Jensen AG; Jeppesen NS; Kristensen AS; Strømgaard K
    J Med Chem; 2014 Jun; 57(11):4940-9. PubMed ID: 24824658
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design of antagonists for NMDA and AMPA receptors.
    Bolshakov KV; Kim KH; Potapjeva NN; Gmiro VE; Tikhonov DB; Usherwood PN; Mellor IR; Magazanik LG
    Neuropharmacology; 2005 Aug; 49(2):144-55. PubMed ID: 15996563
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.
    Tamiz AP; Whittemore ER; Zhou ZL; Huang JC; Drewe JA; Chen JC; Cai SX; Weber E; Woodward RM; Keana JF
    J Med Chem; 1998 Aug; 41(18):3499-506. PubMed ID: 9719603
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The effects of conformational constraints in the polyamine moiety of philanthotoxins on AMPAR inhibition.
    Franzyk H; Grzeskowiak JW; Tikhonov DB; Jaroszewski JW; Mellor IR
    ChemMedChem; 2014 Aug; 9(8):1725-31. PubMed ID: 25044789
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.
    Tamiz AP; Cai SX; Zhou ZL; Yuen PW; Schelkun RM; Whittemore ER; Weber E; Woodward RM; Keana JF
    J Med Chem; 1999 Aug; 42(17):3412-20. PubMed ID: 10464027
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
    Frølund B; Greenwood JR; Holm MM; Egebjerg J; Madsen U; Nielsen B; Bräuner-Osborne H; Stensbøl TB; Krogsgaard-Larsen P
    Bioorg Med Chem; 2005 Sep; 13(18):5391-8. PubMed ID: 16043357
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.
    Randle JC; Guet T; Bobichon C; Moreau C; Curutchet P; Lambolez B; de Carvalho LP; Cordi A; Lepagnol JM
    Mol Pharmacol; 1992 Feb; 41(2):337-45. PubMed ID: 1371583
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.
    Wright JL; Gregory TF; Bigge CF; Boxer PA; Serpa K; Meltzer LT; Wise LD; Cai SX; Hawkinson JE; Konkoy CS; Whittemore ER; Woodward RM; Zhou ZL
    J Med Chem; 1999 Jul; 42(13):2469-77. PubMed ID: 10395488
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Benzyl-polyamines: novel, potent N-methyl-D-aspartate receptor antagonists.
    Igarashi K; Shirahata A; Pahk AJ; Kashiwagi K; Williams K
    J Pharmacol Exp Ther; 1997 Nov; 283(2):533-40. PubMed ID: 9353367
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.