BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 20875742)

  • 1. Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.
    Bandyopadhyaya AK; Manion BD; Benz A; Taylor A; Rath NP; Evers AS; Zorumski CF; Mennerick S; Covey DF
    Bioorg Med Chem Lett; 2010 Nov; 20(22):6680-4. PubMed ID: 20875742
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.
    Stastna E; Krishnan K; Manion BD; Taylor A; Rath NP; Chen ZW; Evers AS; Zorumski CF; Mennerick S; Covey DF
    J Med Chem; 2011 Jun; 54(11):3926-34. PubMed ID: 21504158
    [TBL] [Abstract][Full Text] [Related]  

  • 3. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.
    Pathirathna S; Brimelow BC; Jagodic MM; Krishnan K; Jiang X; Zorumski CF; Mennerick S; Covey DF; Todorovic SM; Jevtovic-Todorovic V
    Pain; 2005 Apr; 114(3):429-443. PubMed ID: 15777868
    [TBL] [Abstract][Full Text] [Related]  

  • 4. [The anesthetic effects of steroids and their actions on the properties of model membrane].
    Tatara T
    Masui; 1992 Sep; 41(9):1419-25. PubMed ID: 1433872
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A neurosteroid anesthetic, alphaxalone, inhibits nicotinic acetylcholine receptors in cultured bovine adrenal chromaffin cells.
    Shiraishi M; Shibuya I; Minami K; Uezono Y; Okamoto T; Yanagihara N; Ueno S; Ueta Y; Shigematsu A
    Anesth Analg; 2002 Oct; 95(4):900-6, table of contents. PubMed ID: 12351265
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms.
    Maitra R; Reynolds JN
    Can J Physiol Pharmacol; 1998 Sep; 76(9):909-20. PubMed ID: 10066142
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of the anesthetic steroid alphaxalone and its inactive delta 16-analog on the thermotropic properties of membrane bilayers. A model for membrane perturbation.
    Mavromoustakos T; Yang DP; Makriyannis A
    Biochim Biophys Acta; 1995 Nov; 1239(2):257-64. PubMed ID: 7488631
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at gamma-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes.
    Sanna E; Murgia A; Casula A; Biggio G
    Mol Pharmacol; 1997 Mar; 51(3):484-90. PubMed ID: 9058604
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural basis of neurosteroid anesthetic action on GABA
    Chen Q; Wells MM; Arjunan P; Tillman TS; Cohen AE; Xu Y; Tang P
    Nat Commun; 2018 Sep; 9(1):3972. PubMed ID: 30266951
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Preemptive analgesic effects of steroid anesthesia with alphaxalone in the rat formalin test. Evidence for differential GABA(A) Receptor modulation in persistent nociception.
    Gilron I; Coderre TJ
    Anesthesiology; 1996 Mar; 84(3):572-9. PubMed ID: 8659786
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Anxiolytic activity of steroid anesthetic alphaxalone.
    Britton KT; Page M; Baldwin H; Koob GF
    J Pharmacol Exp Ther; 1991 Jul; 258(1):124-9. PubMed ID: 1677035
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Potentiation of gamma-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones.
    Barker JL; Harrison NL; Lange GD; Owen DG
    J Physiol; 1987 May; 386():485-501. PubMed ID: 2445967
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-selective anesthetic action of steroids: anesthetic potency and effects on lipid and protein.
    Ueda I; Tatara T; Chiou JS; Krishna PR; Kamaya H
    Anesth Analg; 1994 Apr; 78(4):718-25. PubMed ID: 8135392
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The inhibitory effects of alphaxalone on M1 and M3 muscarinic receptors expressed in Xenopus oocytes.
    Shiraishi M; Minami K; Shibuya I; Uezono Y; Ogata J; Okamoto T; Murasaki O; Kaibara M; Ueta Y; Shigematsu A
    Anesth Analg; 2003 Aug; 97(2):449-455. PubMed ID: 12873933
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
    Borowicz KK; Zadrozniak M; Swiader M; Kowalska A; Kleinrok Z; Czuczwar SJ
    Eur J Pharmacol; 2002 Aug; 449(1-2):85-90. PubMed ID: 12163110
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A steroid anesthetic prolongs inhibitory postsynaptic currents in cultured rat hippocampal neurons.
    Harrison NL; Vicini S; Barker JL
    J Neurosci; 1987 Feb; 7(2):604-9. PubMed ID: 3819824
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The general anesthetic propofol enhances the function of gamma-aminobutyric acid-coupled chloride channel in the rat cerebral cortex.
    Concas A; Santoro G; Mascia MP; Serra M; Sanna E; Biggio G
    J Neurochem; 1990 Dec; 55(6):2135-8. PubMed ID: 2172469
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modulation of GABAA receptor activity by alphaxalone.
    Cottrell GA; Lambert JJ; Peters JA
    Br J Pharmacol; 1987 Mar; 90(3):491-500. PubMed ID: 3032320
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity.
    Todorovic SM; Prakriya M; Nakashima YM; Nilsson KR; Han M; Zorumski CF; Covey DF; Lingle CJ
    Mol Pharmacol; 1998 Nov; 54(5):918-27. PubMed ID: 9804627
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Geometric requirements for membrane perturbation and anesthetic activity. Conformational analysis of alphaxalone and delta 16-alphaxalone and 2H NMR studies on their interactions with model membranes.
    Fesik SW; Makriyannis A
    Mol Pharmacol; 1985 Jun; 27(6):624-9. PubMed ID: 4000106
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.