327 related articles for article (PubMed ID: 20884664)
1. A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.
Jodelka FM; Ebert AD; Duelli DM; Hastings ML
Hum Mol Genet; 2010 Dec; 19(24):4906-17. PubMed ID: 20884664
[TBL] [Abstract][Full Text] [Related]
2. 5-(N-ethyl-N-isopropyl)-amiloride enhances SMN2 exon 7 inclusion and protein expression in spinal muscular atrophy cells.
Yuo CY; Lin HH; Chang YS; Yang WK; Chang JG
Ann Neurol; 2008 Jan; 63(1):26-34. PubMed ID: 17924536
[TBL] [Abstract][Full Text] [Related]
3. Securinine enhances SMN2 exon 7 inclusion in spinal muscular atrophy cells.
Chen YC; Chang JG; Liu TY; Jong YJ; Cheng WL; Yuo CY
Biomed Pharmacother; 2017 Apr; 88():708-714. PubMed ID: 28152480
[TBL] [Abstract][Full Text] [Related]
4. Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.
Cartegni L; Hastings ML; Calarco JA; de Stanchina E; Krainer AR
Am J Hum Genet; 2006 Jan; 78(1):63-77. PubMed ID: 16385450
[TBL] [Abstract][Full Text] [Related]
5. Combined treatment with the histone deacetylase inhibitor LBH589 and a splice-switch antisense oligonucleotide enhances SMN2 splicing and SMN expression in Spinal Muscular Atrophy cells.
Pagliarini V; Guerra M; Di Rosa V; Compagnucci C; Sette C
J Neurochem; 2020 Apr; 153(2):264-275. PubMed ID: 31811660
[TBL] [Abstract][Full Text] [Related]
6. Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs.
Madocsai C; Lim SR; Geib T; Lam BJ; Hertel KJ
Mol Ther; 2005 Dec; 12(6):1013-22. PubMed ID: 16226920
[TBL] [Abstract][Full Text] [Related]
7. Heat increases full-length SMN splicing: promise for splice-augmenting therapies for SMA.
Dominguez CE; Cunningham D; Venkataramany AS; Chandler DS
Hum Genet; 2022 Feb; 141(2):239-256. PubMed ID: 35088120
[TBL] [Abstract][Full Text] [Related]
8. A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.
Gladman JT; Bebee TW; Edwards C; Wang X; Sahenk Z; Rich MM; Chandler DS
Hum Mol Genet; 2010 Nov; 19(21):4239-52. PubMed ID: 20705738
[TBL] [Abstract][Full Text] [Related]
9. Htra2-beta 1 stimulates an exonic splicing enhancer and can restore full-length SMN expression to survival motor neuron 2 (SMN2).
Hofmann Y; Lorson CL; Stamm S; Androphy EJ; Wirth B
Proc Natl Acad Sci U S A; 2000 Aug; 97(17):9618-23. PubMed ID: 10931943
[TBL] [Abstract][Full Text] [Related]
10. A negatively acting bifunctional RNA increases survival motor neuron both in vitro and in vivo.
Dickson A; Osman E; Lorson CL
Hum Gene Ther; 2008 Nov; 19(11):1307-15. PubMed ID: 19848583
[TBL] [Abstract][Full Text] [Related]
11. Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Zhao X; Feng Z; Ling KK; Mollin A; Sheedy J; Yeh S; Petruska J; Narasimhan J; Dakka A; Welch EM; Karp G; Chen KS; Metzger F; Ratni H; Lotti F; Tisdale S; Naryshkin NA; Pellizzoni L; Paushkin S; Ko CP; Weetall M
Hum Mol Genet; 2016 May; 25(10):1885-1899. PubMed ID: 26931466
[TBL] [Abstract][Full Text] [Related]
12. A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy.
Ruggiu M; McGovern VL; Lotti F; Saieva L; Li DK; Kariya S; Monani UR; Burghes AH; Pellizzoni L
Mol Cell Biol; 2012 Jan; 32(1):126-38. PubMed ID: 22037760
[TBL] [Abstract][Full Text] [Related]
13. Revealing diverse alternative splicing variants of the highly homologous SMN1 and SMN2 genes by targeted long-read sequencing.
Dai M; Xu Y; Sun Y; Xiao B; Ying X; Liu Y; Jiang W; Zhang J; Liu X; Ji X
Mol Genet Genomics; 2022 Jul; 297(4):1039-1048. PubMed ID: 35612622
[TBL] [Abstract][Full Text] [Related]
14. The oral splicing modifier RG7800 increases full length survival of motor neuron 2 mRNA and survival of motor neuron protein: Results from trials in healthy adults and patients with spinal muscular atrophy.
Kletzl H; Marquet A; Günther A; Tang W; Heuberger J; Groeneveld GJ; Birkhoff W; Mercuri E; Lochmüller H; Wood C; Fischer D; Gerlach I; Heinig K; Bugawan T; Dziadek S; Kinch R; Czech C; Khwaja O
Neuromuscul Disord; 2019 Jan; 29(1):21-29. PubMed ID: 30553700
[TBL] [Abstract][Full Text] [Related]
15. Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model.
Bebee TW; Dominguez CE; Samadzadeh-Tarighat S; Akehurst KL; Chandler DS
Hum Mol Genet; 2012 Oct; 21(19):4301-13. PubMed ID: 22763238
[TBL] [Abstract][Full Text] [Related]
16. Improvement of spinal muscular atrophy via correction of the SMN2 splicing defect by Brucea javanica (L.) Merr. extract and Bruceine D.
Baek J; Jeong H; Ham Y; Jo YH; Choi M; Kang M; Son B; Choi S; Ryu HW; Kim J; Shen H; Sydara K; Lee SW; Kim SY; Han SB; Oh SR; Cho S
Phytomedicine; 2019 Dec; 65():153089. PubMed ID: 31563042
[TBL] [Abstract][Full Text] [Related]
17. Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy.
Hastings ML; Berniac J; Liu YH; Abato P; Jodelka FM; Barthel L; Kumar S; Dudley C; Nelson M; Larson K; Edmonds J; Bowser T; Draper M; Higgins P; Krainer AR
Sci Transl Med; 2009 Nov; 1(5):5ra12. PubMed ID: 20161659
[TBL] [Abstract][Full Text] [Related]
18. An in vivo reporter system for measuring increased inclusion of exon 7 in SMN2 mRNA: potential therapy of SMA.
Zhang ML; Lorson CL; Androphy EJ; Zhou J
Gene Ther; 2001 Oct; 8(20):1532-8. PubMed ID: 11704813
[TBL] [Abstract][Full Text] [Related]
19. Regulation of Survival Motor Neuron Gene Expression by Calcium Signaling.
Choi K; Yang A; Baek J; Jeong H; Kang Y; Baek W; Kim JC; Kang M; Choi M; Ham Y; Son MJ; Han SB; Kim J; Jang JH; Ahn JS; Shen H; Woo SH; Kim JH; Cho S
Int J Mol Sci; 2021 Sep; 22(19):. PubMed ID: 34638572
[TBL] [Abstract][Full Text] [Related]
20. A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy.
Kashima T; Manley JL
Nat Genet; 2003 Aug; 34(4):460-3. PubMed ID: 12833158
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
