BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

289 related articles for article (PubMed ID: 20939815)

  • 1. False positives in the early stages of drug discovery.
    Sink R; Gobec S; Pečar S; Zega A
    Curr Med Chem; 2010; 17(34):4231-55. PubMed ID: 20939815
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Frequent hitters: nuisance artifacts in high-throughput screening.
    Yang ZY; He JH; Lu AP; Hou TJ; Cao DS
    Drug Discov Today; 2020 Apr; 25(4):657-667. PubMed ID: 31987936
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Integration of virtual and high throughput screening in lead discovery settings.
    Polgár T; Keseru GM
    Comb Chem High Throughput Screen; 2011 Dec; 14(10):889-97. PubMed ID: 21843143
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modern drug discovery technologies: opportunities and challenges in lead discovery.
    Guido RV; Oliva G; Andricopulo AD
    Comb Chem High Throughput Screen; 2011 Dec; 14(10):830-9. PubMed ID: 21843147
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Non-stoichiometric inhibition in integrated lead finding - a literature review.
    Klumpp M
    Expert Opin Drug Discov; 2016; 11(2):149-62. PubMed ID: 26653534
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Scopy: an integrated negative design python library for desirable HTS/VS database design.
    Yang ZY; Yang ZJ; Lu AP; Hou TJ; Cao DS
    Brief Bioinform; 2021 May; 22(3):. PubMed ID: 32892221
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Identifying actives from HTS data sets: practical approaches for the selection of an appropriate HTS data-processing method and quality control review.
    Shun TY; Lazo JS; Sharlow ER; Johnston PA
    J Biomol Screen; 2011 Jan; 16(1):1-14. PubMed ID: 21160066
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Case studies of minimizing nonspecific inhibitors in HTS campaigns that use assay-ready plates.
    Liu Y; Beresini MH; Johnson A; Mintzer R; Shah K; Clark K; Schmidt S; Lewis C; Liimatta M; Elliott LO; Gustafson A; Heise CE
    J Biomol Screen; 2012 Feb; 17(2):225-36. PubMed ID: 21940710
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel trends in high-throughput screening.
    Mayr LM; Bojanic D
    Curr Opin Pharmacol; 2009 Oct; 9(5):580-8. PubMed ID: 19775937
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Early phase drug discovery: cheminformatics and computational techniques in identifying lead series.
    Duffy BC; Zhu L; Decornez H; Kitchen DB
    Bioorg Med Chem; 2012 Sep; 20(18):5324-42. PubMed ID: 22938785
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Lead discovery for mammalian elongation of long chain fatty acids family 6 using a combination of high-throughput fluorescent-based assay and RapidFire mass spectrometry assay.
    Takamiya M; Sakurai M; Teranishi F; Ikeda T; Kamiyama T; Asai A
    Biochem Biophys Res Commun; 2016 Nov; 480(4):721-726. PubMed ID: 27793673
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Industrial medicinal chemistry insights: neuroscience hit generation at Janssen.
    Tresadern G; Rombouts FJR; Oehlrich D; Macdonald G; Trabanco AA
    Drug Discov Today; 2017 Oct; 22(10):1478-1488. PubMed ID: 28669605
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Biophysics: for HTS hit validation, chemical lead optimization, and beyond.
    Genick CC; Wright SK
    Expert Opin Drug Discov; 2017 Sep; 12(9):897-907. PubMed ID: 28658992
    [TBL] [Abstract][Full Text] [Related]  

  • 14. ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens.
    Huth JR; Mendoza R; Olejniczak ET; Johnson RW; Cothron DA; Liu Y; Lerner CG; Chen J; Hajduk PJ
    J Am Chem Soc; 2005 Jan; 127(1):217-24. PubMed ID: 15631471
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Toxicology Strategies for Drug Discovery: Present and Future.
    Blomme EA; Will Y
    Chem Res Toxicol; 2016 Apr; 29(4):473-504. PubMed ID: 26588328
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The essential roles of chemistry in high-throughput screening triage.
    Dahlin JL; Walters MA
    Future Med Chem; 2014 Jul; 6(11):1265-90. PubMed ID: 25163000
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Virtual screening in drug design and development.
    Sousa SF; Cerqueira NM; Fernandes PA; Ramos MJ
    Comb Chem High Throughput Screen; 2010 Jun; 13(5):442-53. PubMed ID: 20236061
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
    Sanders JM; Beshore DC; Culberson JC; Fells JI; Imbriglio JE; Gunaydin H; Haidle AM; Labroli M; Mattioni BE; Sciammetta N; Shipe WD; Sheridan RP; Suen LM; Verras A; Walji A; Joshi EM; Bueters T
    J Med Chem; 2017 Aug; 60(16):6771-6780. PubMed ID: 28418656
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Biodiversity of small molecules--a new perspective in screening set selection.
    Petrone PM; Wassermann AM; Lounkine E; Kutchukian P; Simms B; Jenkins J; Selzer P; Glick M
    Drug Discov Today; 2013 Jul; 18(13-14):674-80. PubMed ID: 23454345
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Polymerase assays for lead discovery: An overall review of methodologies and approaches.
    Nasiri AH; Nasiri HR
    Anal Biochem; 2018 Dec; 563():40-50. PubMed ID: 30291837
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.